Hemolytic-uremic syndrome - Revision history

Aidan at 13:29, 20 April 2023

2023-04-20T13:29:54Z

← Older revision		Revision as of 13:29, 20 April 2023
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	*Typical HUS is a [[thrombotic microangiopathy]] with prominent renal failure traditionally associated with Shiga toxin-producing [[Escherichia coli]] infection, especially enterohemorrhagic ''E. coli'' O157:H7		*Typical HUS is a [[thrombotic microangiopathy]] with prominent renal failure traditionally associated with Shiga toxin-producing [[Escherichia coli]] infection, especially enterohemorrhagic ''E. coli'' O157:H7
	*~~Difference~~ pathophysiology and treatment from [[atypical hemolytic-uremic syndrome]]		*Different pathophysiology and treatment from [[atypical hemolytic-uremic syndrome]] and [[secondary hemolytic-uremic syndrome]]

	===Pathophysiology===		===Pathophysiology===

Aidan: /* Pathophysiology */

2020-08-23T00:33:34Z

Pathophysiology

← Older revision		Revision as of 00:33, 23 August 2020
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	*Typical HUS is caused by Shiga toxin from enterohemorrhagic [[Escherichia coli]] (e.g. O157:H7)		*Typical HUS is caused by Shiga toxin from enterohemorrhagic [[Escherichia coli]] (e.g. O157:H7)
	*~~Toxin~~ is absorbed systemically~~, causing platelet activation and aggregation~~		*Shiga toxin is absorbed systemically
			**Damages vascular endothelial cells leading to cytokine release and thrombus formation
			**Actives complement and binds Factor H (a complement regulator)

	===Risk Factors===		===Risk Factors===

Aidan: typo

2020-08-20T17:36:02Z

typo

← Older revision		Revision as of 17:36, 20 August 2020
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	==Background==		==Background==

	*Typical HUS is a [[~~Thrombotic~~ microangiopathy]] with prominent renal failure traditionally associated with Shiga toxin-producing [[Escherichia coli]] infection, especially enterohemorrhagic ''E. coli'' O157:H7		*Typical HUS is a [[thrombotic microangiopathy]] with prominent renal failure traditionally associated with Shiga toxin-producing [[Escherichia coli]] infection, especially enterohemorrhagic ''E. coli'' O157:H7
	*Difference pathophysiology and treatment from [[atypical hemolytic-uremic syndrome]]		*Difference pathophysiology and treatment from [[atypical hemolytic-uremic syndrome]]

Aidan: /* Clinical Manifestations */

2020-08-15T12:25:56Z

Clinical Manifestations

← Older revision		Revision as of 12:25, 15 August 2020
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	*Difference pathophysiology and treatment from [[atypical hemolytic-uremic syndrome]]		*Difference pathophysiology and treatment from [[atypical hemolytic-uremic syndrome]]

	=== Pathophysiology ===		===Pathophysiology===

	* Typical HUS is caused by Shiga toxin from enterohemorrhagic [[Escherichia coli]] (e.g. O157:H7)		*Typical HUS is caused by Shiga toxin from enterohemorrhagic [[Escherichia coli]] (e.g. O157:H7)
	* Toxin is absorbed systemically, causing platelet activation and aggregation		*Toxin is absorbed systemically, causing platelet activation and aggregation

	=== Risk Factors ===		===Risk Factors===

	* Younger age		*Younger age
	* Exposure to antibiotics		*Exposure to antibiotics
	* Increased WBC count		*Increased WBC count
	* Vomiting		*Vomiting
	* Prolonged diarrhea		*Prolonged diarrhea
	* Presence of ''stx2a'' and ''eae'' genes		*Presence of ''stx2a'' and ''eae'' genes

	== Clinical Manifestations ==		==Clinical Manifestations==

			*Abdominal pain and watery diarrhea about 4 days after exposure to toxin, progressing to bloody diarrhea with or without [[vomiting]]
	* A ~~few~~ ~~days~~ of bloody diarrhea		**Up to one third do not have bloody diarrhea
⚫	* Progression of [[hemolytic anemia]], [[thrombocytopenia]], and severe [[AKI]]
			**Fever is mild or absent
			*About 7 days after onset of diarrhea, HUS develops
		⚫	**Progression of [[hemolytic anemia]], [[thrombocytopenia]], and severe [[AKI]]
			*Other preceding infections can include [[UTI]], [[SSTI]], or other causes of [[gastroenteritis]]

	== Management ==		==Management==

	* Supportive		*Supportive

	[[Category:Hematology]]		[[Category:Hematology]]

Aidan at 11:28, 15 August 2020

2020-08-15T11:28:36Z

@@ Line 1: / Line 1: @@
-== Background ==
+==Background==
-* [[Thrombotic microangiopathy]] with prominent renal failure traditionally associated with Shiga toxin-producing [[Escherichia coli]] infection, especially enterohemorrhagic ''E. coli''
+*Typical HUS is a [[Thrombotic microangiopathy]] with prominent renal failure traditionally associated with Shiga toxin-producing [[Escherichia coli]] infection, especially enterohemorrhagic ''E. coli'' O157:H7
 [[Category:Hematology]]

Aidan: Created page with "== Background == * Thrombotic microangiopathy with prominent renal failure traditionally associated with Shiga toxin-producing Escherichia coli infection, especially e..."

2020-08-14T21:40:41Z

Created page with "== Background == * Thrombotic microangiopathy with prominent renal failure traditionally associated with Shiga toxin-producing Escherichia coli infection, especially e..."

New page

== Background ==
* [[Thrombotic microangiopathy]] with prominent renal failure traditionally associated with Shiga toxin-producing [[Escherichia coli]] infection, especially enterohemorrhagic ''E. coli''
* Much more common in pediatric patients, followed by elderly patients

[[Category:Hematology]]