HIV-tuberculosis coinfection - Revision history

Aidan: /* Active Tuberculosis */

2022-01-05T18:49:30Z

Active Tuberculosis

← Older revision		Revision as of 18:49, 5 January 2022
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	*Regimens that minimize drug-drug interactions:		*Regimens that minimize drug-drug interactions:
	**[[Efavirenz]] 600 mg PO daily or [[raltegravir]] 400 mg PO bid, combined with [[abacavir]]/[[lamivudine]] or [[tenofovir disoproxil fumarate]]/[[emtricitabine]]		**[[Efavirenz]] 600 mg PO daily or [[raltegravir]] 400 mg PO bid, combined with [[abacavir]]/[[lamivudine]] or [[tenofovir disoproxil fumarate]]/[[emtricitabine]]
	**[[~~tenofovir~~ disoproxil fumarate]]/[[emtricitabine]] + [[efavirenz]]		**[[Tenofovir disoproxil fumarate]]/[[emtricitabine]] + [[efavirenz]]
	**[[~~tenofovir~~ disoproxil fumarate]]/[[emtricitabine]] + double [[raltegravir]]		**[[Tenofovir disoproxil fumarate]]/[[emtricitabine]] + double [[raltegravir]]
	**[[Abacavir]]/[[lamivudine]] with BID [[dolutegravir]]		**[[Abacavir]]/[[lamivudine]] with BID [[dolutegravir]]
	**[[Tenofovir alafenamide]] may or may not be affected by [[rifampin]]		**[[Tenofovir alafenamide]] may or may not be affected by [[rifampin]]

Aidan: /* Active Tuberculosis */

2020-10-22T14:23:39Z

Active Tuberculosis

← Older revision		Revision as of 14:23, 22 October 2020
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	**Start TB treatment immediately		**Start TB treatment immediately
	**If not already on HIV treatment:		**If not already on HIV treatment:
	***CD4 count <50 cells/mm<sup>3</sup>: start as soon as possible, and within 2 weeks of TB treatment		***CD4 count <50 cells/mm<sup>3</sup>: start HIV treatment as soon as possible, and within 2 weeks of TB treatment
	***CD4 count ≥50 cells/mm<sup>3</sup>: start within 8 weeks of TB treatment		***CD4 count ≥50 cells/mm<sup>3</sup>: start HIV treatment within 8 weeks of TB treatment
	***Pregnancy, regardless of CD4: start as soon as feasible, to prevent transmission		***Pregnancy, regardless of CD4: start as soon as feasible, to prevent transmission
	**With tuberculous meningitis, monitor closely when starting early		**With tuberculous meningitis, generally defer to 8 weeks, or monitor closely when starting early

	[[Category:HIV]]		[[Category:HIV]]

Aidan at 01:22, 4 September 2020

2020-09-04T01:22:41Z

← Older revision		Revision as of 01:22, 4 September 2020
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	*[[Rifampin]] is a core antimicrobial for tuberculosis and should be given priority in drug-drug interactions		*[[Rifampin]] is a core antimicrobial for tuberculosis and should be given priority in drug-drug interactions
	*NRTIs do not require any adjustment, INSTIs and NRTIs often need dose adjustment, and PIs are usually contraindicated		*NRTIs do not require any adjustment, INSTIs and NRTIs often need dose adjustment, and PIs are usually contraindicated
	*Regimens that do ~~not~~ ~~require dose adjustment~~:		*Regimens that minimize drug-drug interactions:
	**[[Efavirenz]] 600 mg PO daily or [[raltegravir]] 400 mg PO bid, combined with [[abacavir]]/[[lamivudine]] or [[tenofovir disoproxil fumarate]]/[[emtricitabine]]		**[[Efavirenz]] 600 mg PO daily or [[raltegravir]] 400 mg PO bid, combined with [[abacavir]]/[[lamivudine]] or [[tenofovir disoproxil fumarate]]/[[emtricitabine]]
			**[[tenofovir disoproxil fumarate]]/[[emtricitabine]] + [[efavirenz]]
			**[[tenofovir disoproxil fumarate]]/[[emtricitabine]] + double [[raltegravir]]
			**[[Abacavir]]/[[lamivudine]] with BID [[dolutegravir]]
	**[[Tenofovir alafenamide]] may or may not be affected by [[rifampin]]		**[[Tenofovir alafenamide]] may or may not be affected by [[rifampin]]
	*Timing		*Timing

Aidan: /* Active Tuberculosis */

2020-08-13T12:46:37Z

Active Tuberculosis

← Older revision		Revision as of 12:46, 13 August 2020
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	== Management ==		==Management==

	=== Latent Tuberculosis Infection ===		===Latent Tuberculosis Infection===

	* When using [[isoniazid]] monotherapy, can use any HIV medication		*When using [[isoniazid]] monotherapy, can use any HIV medication
	* When using [[rifampin]] or [[rifapentine]], need to check for drug-drug interactions		*When using [[rifampin]] or [[rifapentine]], need to check for drug-drug interactions

	=== Active Tuberculosis ===		===Active Tuberculosis===

	* [[Rifampin]] is a core antimicrobial for tuberculosis and should be given priority in drug-drug interactions		*[[Rifampin]] is a core antimicrobial for tuberculosis and should be given priority in drug-drug interactions
	* ~~Regimens that~~ do not require dose adjustment:		*NRTIs do not require any adjustment, INSTIs and NRTIs often need dose adjustment, and PIs are usually contraindicated
			*Regimens that do not require dose adjustment:
	** [[Efavirenz]] 600 mg PO daily or [[raltegravir]] 400 mg PO bid, combined with [[abacavir]]/[[lamivudine]] or [[tenofovir disoproxil fumarate]]/[[emtricitabine]]		**[[Efavirenz]] 600 mg PO daily or [[raltegravir]] 400 mg PO bid, combined with [[abacavir]]/[[lamivudine]] or [[tenofovir disoproxil fumarate]]/[[emtricitabine]]
⚫	* Timing
			**[[Tenofovir alafenamide]] may or may not be affected by [[rifampin]]
⚫	** Start TB treatment immediately
		⚫	*Timing
⚫	** If not already on HIV treatment:
		⚫	**Start TB treatment immediately
⚫	*** CD4 count ~~<50~~ cells/mm<sup>3</sup>: start ~~as soon as possible, and~~ within 2 weeks of TB treatment
		⚫	**If not already on HIV treatment:
	*** CD4 count ≥50 cells/mm<sup>3</sup>: start within 8 weeks of TB treatment
	*** ~~Pregnancy,~~ ~~regardless~~ ~~of CD4~~: start as soon as ~~feasible~~, to ~~prevent~~ ~~transmission~~		***CD4 count <50 cells/mm<sup>3</sup>: start as soon as possible, and within 2 weeks of TB treatment
		⚫	***CD4 count ≥50 cells/mm<sup>3</sup>: start within 8 weeks of TB treatment
⚫	** With tuberculous meningitis, monitor closely when starting early
			***Pregnancy, regardless of CD4: start as soon as feasible, to prevent transmission
		⚫	**With tuberculous meningitis, monitor closely when starting early

	[[Category:HIV]]		[[Category:HIV]]

Aidan: Created page with "== Management == === Latent Tuberculosis Infection === * When using isoniazid monotherapy, can use any HIV medication * When using rifampin or rifapentine, need..."

2020-08-06T21:06:07Z

Created page with "== Management == === Latent Tuberculosis Infection === * When using isoniazid monotherapy, can use any HIV medication * When using rifampin or rifapentine, need..."

New page

== Management ==

=== Latent Tuberculosis Infection ===

* When using [[isoniazid]] monotherapy, can use any HIV medication
* When using [[rifampin]] or [[rifapentine]], need to check for drug-drug interactions

=== Active Tuberculosis ===

* [[Rifampin]] is a core antimicrobial for tuberculosis and should be given priority in drug-drug interactions
* Regimens that do not require dose adjustment:
** [[Efavirenz]] 600 mg PO daily or [[raltegravir]] 400 mg PO bid, combined with [[abacavir]]/[[lamivudine]] or [[tenofovir disoproxil fumarate]]/[[emtricitabine]]
* Timing
** Start TB treatment immediately
** If not already on HIV treatment:
*** CD4 count <50 cells/mm<sup>3</sup>: start as soon as possible, and within 2 weeks of TB treatment
*** CD4 count ≥50 cells/mm<sup>3</sup>: start within 8 weeks of TB treatment
*** Pregnancy, regardless of CD4: start as soon as feasible, to prevent transmission
** With tuberculous meningitis, monitor closely when starting early

[[Category:HIV]]
[[Category:Tuberculosis]]
[[Category:Infectious diseases]]