Guillain-Barré syndrome - Revision history

Aidan: /* Investigations */

2024-09-30T17:56:23Z

Investigations

← Older revision		Revision as of 17:56, 30 September 2024
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	== Investigations ==		== Investigations ==

	* Lumbar puncture, with CSF classically showing albuminocytologic dissociation (elevated protein with ~~normal~~ white count), though neither normal protein levels nor elevated white cells exclude the diagnosis[[CiteRef::al-hakem2023cs]]		* Lumbar puncture, with CSF classically showing albuminocytologic dissociation (elevated protein with white count less than 50), though neither normal protein levels nor elevated white cells exclude the diagnosis[[CiteRef::al-hakem2023cs]]

	==Further Reading==		==Further Reading==

Aidan at 17:52, 30 September 2024

2024-09-30T17:52:10Z

← Older revision		Revision as of 17:52, 30 September 2024
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	* [[Botulism]], [[myasthenia gravis]], [[Lambert-Eaton syndrome]]		* [[Botulism]], [[myasthenia gravis]], [[Lambert-Eaton syndrome]]
	* Acute [[polymyositis]], [[dermatomyositis]], [[necrotizing myopathy]], [[critical illness neuropathy]]		* Acute [[polymyositis]], [[dermatomyositis]], [[necrotizing myopathy]], [[critical illness neuropathy]]

			== Investigations ==

			* Lumbar puncture, with CSF classically showing albuminocytologic dissociation (elevated protein with normal white count), though neither normal protein levels nor elevated white cells exclude the diagnosis[[CiteRef::al-hakem2023cs]]

	==Further Reading==		==Further Reading==

Aidan at 20:07, 22 September 2023

2023-09-22T20:07:56Z

← Older revision		Revision as of 20:07, 22 September 2023
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	===Etiology===		===Etiology===

	*''[[Campylobacter jejuni]]''		*''[[Campylobacter jejuni\|'''Campylobacter jejuni''']]''
	*[[Cytomegalovirus]]		*[[Cytomegalovirus]], [[Haemophilus influenzae]], [[Mycoplasma pneumoniae]], [[Influenza]], [[HIV]]
			*Also [[COVID-19]], [[Zika virus]], [[EBV]], [[HSV]], [[VZV]], [[Chikungunya]], [[Escherichia coli]], [[Japanese encephalitis virus]]
	*[[Epstein-Barr virus]]
			*Non-infectious causes
	*[[Zika virus]]
	*[[~~HIV~~]]		**[[Immunization]]
			**Surgery, trauma
	*Non-infectious causes, including [[immunization]], surgery, trauma, and [[hematopoietic stem cell transplantation]]
			**Medications, including [[TNF-α inhibitors]], [[tacrolimus]], [[suramin]], [[isotretinoin]], and [[immune checkpoint inhibitors]]
			**[[Hematopoietic stem cell transplantation]]

	=== Pathophysiology ===		=== Pathophysiology ===
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	**[[Campylobacter jejuni]] is the most common causative organism identified		**[[Campylobacter jejuni]] is the most common causative organism identified
	**Rare following influenza vaccination; most notable was the 1976 H1N1 vaccine, with about 1 in 100,000 vaccine recipients developing GBS		**Rare following influenza vaccination; most notable was the 1976 H1N1 vaccine, with about 1 in 100,000 vaccine recipients developing GBS

			== Differential Diagnosis ==

			* [[CIDP]]
			* [[Thiamine deficiency]]
			* Polyneuropathy, including [[Arsenic poisoning\|acute arsenic poisoning]] and other toxin-induced peripheral polyneuropathy, [[Lyme disease]], [[tick paralysis]], [[vasculitis]], [[sarcoidosis]], [[porphyria]]
			* [[Leptomeningeal lymphoma]]
			* [[Paraneoplastic syndrome]]
			* [[Spinal cord disorder]]
			* [[Botulism]], [[myasthenia gravis]], [[Lambert-Eaton syndrome]]
			* Acute [[polymyositis]], [[dermatomyositis]], [[necrotizing myopathy]], [[critical illness neuropathy]]

	==Further Reading==		==Further Reading==

Aidan: /* Etiology */

2020-07-14T19:58:57Z

Etiology

← Older revision		Revision as of 19:58, 14 July 2020
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	*[[Zika virus]]		*[[Zika virus]]
	*[[HIV]]		*[[HIV]]
	*Non-infectious causes, including immunization, surgery, trauma, and hematopoietic stem cell transplantation		*Non-infectious causes, including [[immunization]], surgery, trauma, and [[hematopoietic stem cell transplantation]]

	=== Pathophysiology ===		=== Pathophysiology ===

Aidan: /* Background */

2020-07-14T19:56:08Z

Background

← Older revision		Revision as of 19:56, 14 July 2020
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	== Background ==		==Background==

			=== Types ===
	* Causes either acute inflammatory demyelinating polyneuropathy, or acute motor axonal neuropathy, or acute motor and sensory axonal neuropathy

			*Guillain-Barré syndrome
			**Acute inflammatory demyelinating polyneuropathy (AIDP)
			**Acute motor axonal neuropathy
			***Acute motor-sensory axonal neuropathy
			***Acute motor-conduction-block neuropathy
			***Pharyngeal-cervical-branchial weakness
			*Miller Fisher syndrome
			**Incomplete MFS
			***Acute motor-ophthalmoparesis, without ataxia
			***Acute ataxic neyropathy, without ophthalmoparesis
			**Bickerstaff's brainstem encephalitis

	===Etiology===		===Etiology===
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	*Non-infectious causes, including immunization, surgery, trauma, and hematopoietic stem cell transplantation		*Non-infectious causes, including immunization, surgery, trauma, and hematopoietic stem cell transplantation

	=== ~~Epidemiology~~ ===		=== Pathophysiology ===

			* Immune crossreactivity causes autoimmune destruction of either the myelin sheath (AIDP) or the axon itself
			* Most common ADAM antibodies are anti-GM1 or anti-GD1a IgG, which recognize gangliosides
			* Most common MFS antibody is anti-GQ1b IgG (in 90%)

			===Epidemiology===

	* About 1 case per 100,000 people per year in Western countries		*About 1 case per 100,000 people per year in Western countries

	== Clinical Manifestations ==		==Clinical Manifestations==

	* Ascending paralysis ± sensory involvement		*Ascending paralysis ± sensory involvement
	* Usually occurs 1 to 2 weeks after an immune-stimulating even such as illness or vaccination		*Usually occurs 1 to 2 weeks after an immune-stimulating even such as illness or vaccination
	** Preceding illness usually a gastrointestinal or respiratory infection		**Preceding illness usually a gastrointestinal or respiratory infection
	** [[Campylobacter jejuni]] is the most common causative organism identified		**[[Campylobacter jejuni]] is the most common causative organism identified
	** Rare following influenza vaccination; most notable was the 1976 H1N1 vaccine, with about 1 in 100,000 vaccine recipients developing GBS		**Rare following influenza vaccination; most notable was the 1976 H1N1 vaccine, with about 1 in 100,000 vaccine recipients developing GBS

	== Further Reading ==		==Further Reading==

	* Guillain-Barré syndrome. ''Lancet''. 2016;388:717-727. doi: [https://doi.org/10.1016/S0140-6736(16)00339-1 10.1016/S0140-6736(16)00339-1]		*Guillain-Barré syndrome. ''Lancet''. 2016;388:717-727. doi: [https://doi.org/10.1016/S0140-6736(16)00339-1 10.1016/S0140-6736(16)00339-1]

	[[Category:Neurology]]		[[Category:Neurology]]

Aidan at 01:42, 14 July 2020

2020-07-14T01:42:53Z

← Older revision		Revision as of 01:42, 14 July 2020
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	== ~~Etiology~~ ==		== Background ==

⚫	* ''[[Campylobacter jejuni]]''
			* Causes either acute inflammatory demyelinating polyneuropathy, or acute motor axonal neuropathy, or acute motor and sensory axonal neuropathy
⚫	* [[Cytomegalovirus]]

⚫	* [[Epstein-Barr virus]]
			===Etiology===
⚫	* [[Zika virus]]

⚫	* [[HIV]]
		⚫	*''[[Campylobacter jejuni]]''
⚫	* Non-infectious causes, including ~~imunization~~, surgery, trauma, and hematopoietic stem cell transplantation
		⚫	*[[Cytomegalovirus]]
		⚫	*[[Epstein-Barr virus]]
		⚫	*[[Zika virus]]
		⚫	*[[HIV]]
		⚫	*Non-infectious causes, including immunization, surgery, trauma, and hematopoietic stem cell transplantation

			=== Epidemiology ===

			* About 1 case per 100,000 people per year in Western countries

			== Clinical Manifestations ==

			* Ascending paralysis ± sensory involvement
			* Usually occurs 1 to 2 weeks after an immune-stimulating even such as illness or vaccination
			** Preceding illness usually a gastrointestinal or respiratory infection
			** [[Campylobacter jejuni]] is the most common causative organism identified
			** Rare following influenza vaccination; most notable was the 1976 H1N1 vaccine, with about 1 in 100,000 vaccine recipients developing GBS

			== Further Reading ==

			* Guillain-Barré syndrome. ''Lancet''. 2016;388:717-727. doi: [https://doi.org/10.1016/S0140-6736(16)00339-1 10.1016/S0140-6736(16)00339-1]

			[[Category:Neurology]]
			[[Category:Infectious diseases]]

Aidan: Created page with "== Etiology == * ''Campylobacter jejuni'' * Cytomegalovirus * Epstein-Barr virus * Zika virus * HIV * Non-infectious causes, including imunization, surgery..."

2019-11-28T13:51:56Z

Created page with "== Etiology == * ''Campylobacter jejuni'' * Cytomegalovirus * Epstein-Barr virus * Zika virus * HIV * Non-infectious causes, including imunization, surgery..."

New page

== Etiology ==
* ''[[Campylobacter jejuni]]''
* [[Cytomegalovirus]]
* [[Epstein-Barr virus]]
* [[Zika virus]]
* [[HIV]]
* Non-infectious causes, including imunization, surgery, trauma, and hematopoietic stem cell transplantation