Fusarium - Revision history

Aidan: /* Management */

2022-02-12T20:48:37Z

Management

← Older revision		Revision as of 20:48, 12 February 2022
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	*Some species are inherently resistant to amphotericin, so may need to treat with combination amphotericin and voriconazole until susceptibilities are available		*Some species are inherently resistant to amphotericin, so may need to treat with combination amphotericin and voriconazole until susceptibilities are available

	{{DISPLAYTITLE:''Fusarium''		{{DISPLAYTITLE:''Fusarium''}}
	[[Category:Hyaline molds]]		[[Category:Hyaline molds]]

Aidan: Aidan moved page Fusarium species to Fusarium over redirect: Text replacement - " species" to ""

2022-02-01T11:37:43Z

Aidan moved page Fusarium species to Fusarium over redirect: Text replacement - " species" to ""

← Older revision		Revision as of 11:37, 1 February 2022
(No difference)

Aidan: Text replacement - " species}}" to ""

2022-02-01T08:32:56Z

Text replacement - " species}}" to ""

← Older revision		Revision as of 08:32, 1 February 2022
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	*Some species are inherently resistant to amphotericin, so may need to treat with combination amphotericin and voriconazole until susceptibilities are available		*Some species are inherently resistant to amphotericin, so may need to treat with combination amphotericin and voriconazole until susceptibilities are available

	{{DISPLAYTITLE:''Fusarium'' ~~species}}~~		{{DISPLAYTITLE:''Fusarium''
	[[Category:Hyaline molds]]		[[Category:Hyaline molds]]

Aidan: /* Management */

2020-09-10T00:40:28Z

Management

← Older revision		Revision as of 00:40, 10 September 2020
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	== Background ==		==Background==

	===Microbiology===		===Microbiology===
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	**Disseminated infection		**Disseminated infection

	== Management ==		==Management==

	*Remove indwelling lines, if possble		*Remove indwelling lines, if possble
	*Treat underlying immunocompromise, if possible		*Treat underlying immunocompromise, if possible
	*[[Amphotericin B]] (high dose) is the antifungal of choice, although [[voriconazole]] and [[posaconazole]] have also been used		*[[Amphotericin B]] (high dose) is the antifungal of choice, although [[voriconazole]] and [[posaconazole]] have also been used
			*Some species are inherently resistant to amphotericin, so may need to treat with combination amphotericin and voriconazole until susceptibilities are available

	{{DISPLAYTITLE:''Fusarium'' species}}		{{DISPLAYTITLE:''Fusarium'' species}}

Aidan at 15:13, 29 July 2020

2020-07-29T15:13:57Z

← Older revision		Revision as of 15:13, 29 July 2020
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	== ~~Microbiology~~ ==		== Background ==

			===Microbiology===
⚫	* '''Macroscopic:''' colonies grow rapidly with wooly texture (sometimes mucoid), and white, yellow, pink, purple, or pale brown surface and pale, red, violet, brown, or blue reverse.
⚫	* '''Microscopic:''' septate hyaline hyphae. Microconidia are unicellular (sometimes bicellular) and hyaline, ovoid to ellipsoid, in chains or singly from denticles. Macroconidia are curved and multicellular, with a foot cell at the base. Chlamydospores may be present.
⚫	** The macroconidia are the typical finding used to identify ''Fusarium'' spp.

		⚫	*'''Macroscopic:''' colonies grow rapidly with wooly texture (sometimes mucoid), and white, yellow, pink, purple, or pale brown surface and pale, red, violet, brown, or blue reverse.
	=== Species that cause disease ===
		⚫	*'''Microscopic:''' septate hyaline hyphae. Microconidia are unicellular (sometimes bicellular) and hyaline, ovoid to ellipsoid, in chains or singly from denticles. Macroconidia are curved and multicellular, with a foot cell at the base. Chlamydospores may be present.
		⚫	**The macroconidia are the typical finding used to identify ''Fusarium'' spp.
			*Species of medical importance include:
		⚫	**''F. solani'': most common overall, and a common cause of keratitis
		⚫	**''F. oxysporum'': second-most common
		⚫	**''F. verticillioides'': third-most common
		⚫	**''F. moniliforme''
		⚫	**''F. proliferatum''
		⚫	**''F. chlamydosporum''
		⚫	**''F. anthophilum''
		⚫	**''F. dimerum''
		⚫	**''F. sacchari''

		⚫	===Epidemiology===
⚫	* ''F. solani'': most common overall, and a common cause of keratitis
⚫	* ''F. oxysporum'': second-most common
⚫	* ''F. verticillioides'': third-most common
⚫	* ''F. moniliforme''
⚫	* ''F. proliferatum''
⚫	* ''F. chlamydosporum''
⚫	* ''F. anthophilum''
⚫	* ''F. dimerum''
⚫	* ''F. sacchari''

		⚫	*Ubiquitous, common in soil and organic debris, and a common cause of disease in plants.
⚫	== Epidemiology ==
		⚫	*In humans, infection is rare and generally occurs after penetrating trauma.
		⚫	*Disseminated and CNS disease is more common in immunocompromised hosts, including prolonged neutropenia.

		⚫	==Clinical Manifestations==
⚫	* Ubiquitous, common in soil and organic debris, and a common cause of disease in plants.
⚫	* In humans, infection is rare and generally occurs after penetrating trauma.
⚫	* Disseminated and CNS disease is more common in immunocompromised hosts, including prolonged neutropenia.

		⚫	*'''Superficial'''
⚫	== Clinical Manifestations ==
		⚫	**Keratitis and endophthalmitis: big outbreak associated with contact lens solution back in the day
		⚫	**Onychomycosis
		⚫	**Skin and musculoskeletal infections (including mycetoma)
		⚫	*'''Locally invasive'''
		⚫	**Pneumonia
		⚫	**Peritonitis associated with peritoneal dialysis
		⚫	**Brain abscess
		⚫	*'''Disseminated infection'''
		⚫	**Fungemia: can be detected in blood culture
		⚫	**Disseminated infection

		⚫	== Management ==
⚫	* Superficial
⚫	** Keratitis and endophthalmitis: big outbreak associated with contact lens solution back in the day
⚫	** Onychomycosis
⚫	** Skin and musculoskeletal infections (including mycetoma)
⚫	* Locally invasive
⚫	** Pneumonia
⚫	** Peritonitis associated with peritoneal dialysis
⚫	** Brain abscess
⚫	* Disseminated infection
⚫	** Fungemia: can be detected in blood culture
⚫	** Disseminated infection

		⚫	*Remove indwelling lines, if possble
⚫	=== Management ===
		⚫	*Treat underlying immunocompromise, if possible

		⚫	*[[Amphotericin B]] (high dose) is the antifungal of choice, although [[voriconazole]] and [[posaconazole]] have also been used
⚫	* Remove indwelling lines
⚫	* Treat underlying immunocompromise, if possible
⚫	* [[Amphotericin B]] (high dose) is the antifungal of choice, although ~~vori~~ and ~~posa~~ have also been used

	{{DISPLAYTITLE:''Fusarium'' species}}		{{DISPLAYTITLE:''Fusarium'' species}}

Aidan: Text replacement - "Clinical Presentation" to "Clinical Manifestations"

2020-07-21T01:18:50Z

Text replacement - "Clinical Presentation" to "Clinical Manifestations"

← Older revision		Revision as of 01:18, 21 July 2020
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	* Disseminated and CNS disease is more common in immunocompromised hosts, including prolonged neutropenia.		* Disseminated and CNS disease is more common in immunocompromised hosts, including prolonged neutropenia.

	== Clinical ~~Presentation~~ ==		== Clinical Manifestations ==

	* Superficial		* Superficial

Aidan: Initial page creation, split from 'Hyaline molds'

2019-08-23T16:52:03Z

Initial page creation, split from 'Hyaline molds'

New page

== Microbiology ==

* '''Macroscopic:''' colonies grow rapidly with wooly texture (sometimes mucoid), and white, yellow, pink, purple, or pale brown surface and pale, red, violet, brown, or blue reverse.
* '''Microscopic:''' septate hyaline hyphae. Microconidia are unicellular (sometimes bicellular) and hyaline, ovoid to ellipsoid, in chains or singly from denticles. Macroconidia are curved and multicellular, with a foot cell at the base. Chlamydospores may be present.
** The macroconidia are the typical finding used to identify ''Fusarium'' spp.

=== Species that cause disease ===

* ''F. solani'': most common overall, and a common cause of keratitis
* ''F. oxysporum'': second-most common
* ''F. verticillioides'': third-most common
* ''F. moniliforme''
* ''F. proliferatum''
* ''F. chlamydosporum''
* ''F. anthophilum''
* ''F. dimerum''
* ''F. sacchari''

== Epidemiology ==

* Ubiquitous, common in soil and organic debris, and a common cause of disease in plants.
* In humans, infection is rare and generally occurs after penetrating trauma.
* Disseminated and CNS disease is more common in immunocompromised hosts, including prolonged neutropenia.

== Clinical Presentation ==

* Superficial
** Keratitis and endophthalmitis: big outbreak associated with contact lens solution back in the day
** Onychomycosis
** Skin and musculoskeletal infections (including mycetoma)
* Locally invasive
** Pneumonia
** Peritonitis associated with peritoneal dialysis
** Brain abscess
* Disseminated infection
** Fungemia: can be detected in blood culture
** Disseminated infection

=== Management ===

* Remove indwelling lines
* Treat underlying immunocompromise, if possible
* [[Amphotericin B]] (high dose) is the antifungal of choice, although vori and posa have also been used

{{DISPLAYTITLE:''Fusarium'' species}}
[[Category:Hyaline molds]]