Fungal endocarditis - Revision history

Aidan at 17:39, 11 October 2022

2022-10-11T17:39:07Z

← Older revision		Revision as of 17:39, 11 October 2022
Line 1:		Line 1:
			== Background ==

			* Most commonly caused by yeast within the genus [[Candida]], though many species of [[Candida]] are now being reclassified into distinct genera

	== Management ==		== Management ==

			=== Yeast-Related Endocarditis ===
	* Initial treatment with [[Is treated by::liposomal amphotericin B]] 3-5 mg/kg IV daily, ± [[Is treated by::flucytosine]] 25 mg/kg PO qid		* Initial treatment with [[Is treated by::liposomal amphotericin B]] 3-5 mg/kg IV daily, ± [[Is treated by::flucytosine]] 25 mg/kg PO qid
	** Alternative: high-dose echinocandin ([[Is treated by::caspofungin]] 150 mg IV daily, [[Is treated by::micafungin]] 150 mg IV daily, or [[Is treated by::anidulafungin]] 200 mg IV daily)		** Alternative: high-dose echinocandin ([[Is treated by::caspofungin]] 150 mg IV daily, [[Is treated by::micafungin]] 150 mg IV daily, or [[Is treated by::anidulafungin]] 200 mg IV daily)

Aidan: Aidan moved page Candidal endocarditis to Fungal endocarditis

2022-10-11T17:37:34Z

Aidan moved page Candidal endocarditis to Fungal endocarditis

← Older revision		Revision as of 17:37, 11 October 2022
(No difference)

Aidan at 15:01, 16 August 2022

2022-08-16T15:01:35Z

← Older revision		Revision as of 15:01, 16 August 2022
Line 2:		Line 2:
	* Initial treatment with [[Is treated by::liposomal amphotericin B]] 3-5 mg/kg IV daily, ± [[Is treated by::flucytosine]] 25 mg/kg PO qid		* Initial treatment with [[Is treated by::liposomal amphotericin B]] 3-5 mg/kg IV daily, ± [[Is treated by::flucytosine]] 25 mg/kg PO qid
	** Alternative: high-dose echinocandin ([[Is treated by::caspofungin]] 150 mg IV daily, [[Is treated by::micafungin]] 150 mg IV daily, or [[Is treated by::anidulafungin]] 200 mg IV daily)		** Alternative: high-dose echinocandin ([[Is treated by::caspofungin]] 150 mg IV daily, [[Is treated by::micafungin]] 150 mg IV daily, or [[Is treated by::anidulafungin]] 200 mg IV daily)
		⚫	** Antifungal therapy should continue for at least 6 weeks after surgery
	* Step-down suppressive therapy following treatment is lifelong [[Is treated by::fluconazole]] 400-800 mg PO daily
⚫	** Alternative: [[Is treated by::voriconazole]] 200–300 mg (3–4 mg/kg) PO bid or [[Is treated by::posaconazole]] 300 mg PO daily
	* Valve replacement is recommended in essentially all cases of fungal endocarditis		* Valve replacement is recommended in essentially all cases of fungal endocarditis
			** In case of prosthetic valve, this should be followed by lifelong suppressive therapy
⚫	* Antifungal therapy should continue for at least 6 weeks after surgery
	* In ~~case of prosthetic~~ valve, ~~this~~ ~~should~~ be ~~followed~~ by lifelong suppressive therapy		* If the valve is not replaced, step-down to lifelong suppressive therapy following treatment is recommended with [[Is treated by::fluconazole]] 400-800 mg PO daily
		⚫	** Alternative: [[Is treated by::voriconazole]] 200–300 mg (3–4 mg/kg) PO bid or [[Is treated by::posaconazole]] 300 mg PO daily

	[[Category:Cardiac infections]]		[[Category:Cardiac infections]]

Aidan: Created page with "== Management == * Initial treatment with Is treated by::liposomal amphotericin B 3-5 mg/kg IV daily, ± Is treated by::flucytosine 25 mg/kg PO qid ** Alternative: hig..."

2020-02-23T00:11:19Z

Created page with "== Management == * Initial treatment with Is treated by::liposomal amphotericin B 3-5 mg/kg IV daily, ± Is treated by::flucytosine 25 mg/kg PO qid ** Alternative: hig..."

New page

== Management ==
* Initial treatment with [[Is treated by::liposomal amphotericin B]] 3-5 mg/kg IV daily, ± [[Is treated by::flucytosine]] 25 mg/kg PO qid
** Alternative: high-dose echinocandin ([[Is treated by::caspofungin]] 150 mg IV daily, [[Is treated by::micafungin]] 150 mg IV daily, or [[Is treated by::anidulafungin]] 200 mg IV daily)
* Step-down suppressive therapy following treatment is lifelong [[Is treated by::fluconazole]] 400-800 mg PO daily
** Alternative: [[Is treated by::voriconazole]] 200–300 mg (3–4 mg/kg) PO bid or [[Is treated by::posaconazole]] 300 mg PO daily
* Valve replacement is recommended in essentially all cases of fungal endocarditis
* Antifungal therapy should continue for at least 6 weeks after surgery
* In case of prosthetic valve, this should be followed by lifelong suppressive therapy

[[Category:Cardiac infections]]