Essential thrombocythemia - Revision history

Aidan at 13:30, 23 August 2023

2023-08-23T13:30:54Z

← Older revision		Revision as of 13:30, 23 August 2023
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	* CBC with peripheral blood film shows thrombocytosis with platelet anisocytosis		* CBC with peripheral blood film shows thrombocytosis with platelet anisocytosis
	** RBCs usually normochromic and normocytic, unless there is concurrent [[iron deficiency anemia]]		** RBCs usually normochromic and normocytic, unless there is concurrent [[iron deficiency anemia]]
	** Leukoerythroblastic ~~picture~~ suggests post-ET [[myelofibrosis]]		** [[Leukoerythroblastic reaction]] suggests post-ET [[myelofibrosis]]
	* Bone marrow aspiration and biopsy shows normal cellularity or moderate hypercellularity with large megakaryocytes		* Bone marrow aspiration and biopsy shows normal cellularity or moderate hypercellularity with large megakaryocytes
	** Findings that suggest an alternative diagnosis include highly atypical megakaryocytes, increased myeloblasts, myelodysplastic features, or significant reticulin fibrosis or collagen fibrosis		** Findings that suggest an alternative diagnosis include highly atypical megakaryocytes, increased myeloblasts, myelodysplastic features, or significant reticulin fibrosis or collagen fibrosis

Aidan at 14:31, 20 February 2022

2022-02-20T14:31:55Z

← Older revision		Revision as of 14:31, 20 February 2022
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	** MPL in 5%		** MPL in 5%
	** Triple-negative (all above negative) in 10-15%		** Triple-negative (all above negative) in 10-15%
			*Send BCR-ABL testing to exclude [[CML]]

	== WHO Diagnostic Criteria ==		== WHO Diagnostic Criteria ==

Aidan at 14:31, 20 February 2022

2022-02-20T14:31:16Z

@@ Line 17: / Line 17: @@
 == Differential Diagnosis ==
 * Must distinguish from other myelodysplastic disorders (especially [[polycythemia vera]]) as well as from secondary causes of [[thrombocytosis]]
 == Management ==

Aidan at 14:24, 20 February 2022

2022-02-20T14:24:28Z

← Older revision		Revision as of 14:24, 20 February 2022
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	== Definition ==		== Definition ==

	* Myelodysplastic disorder of the thrombocytopoeitic stem cells causing a clonal proliferation of thrombocytes		* [[Myelodysplastic disorder]] of the thrombocytopoeitic stem cells causing a clonal proliferation of thrombocytes

⚫	== Differential Diagnosis ==

⚫	* Must distinguish from other myelodysplastic disorders (especially polycythemia vera) as well as from secondary causes of thrombocytosis

	== Clinical Manifestations ==		== Clinical Manifestations ==
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	** Increased cardiovascular risk		** Increased cardiovascular risk
	** Older than 60 years		** Older than 60 years

		⚫	== Differential Diagnosis ==
		⚫	* Must distinguish from other myelodysplastic disorders (especially [[polycythemia vera]]) as well as from secondary causes of [[thrombocytosis]]

	== Management ==		== Management ==

	* Acute		* Acute
	** If digital or cerebrovascular ischemia, rapid cytoreduction with ~~plateletpheresis~~		** If digital or cerebrovascular ischemia, rapid cytoreduction with platelet pheresis
	* Chronic		* Chronic
	** If high risk, requires cytoreduction and aspirin:		** If high risk, requires cytoreduction and [[aspirin]]:
	*** First-line: hydroxyurea		*** First-line: [[hydroxyurea]]
	*** Alternative: anagrelide		*** Alternative: [[anagrelide]]
	*** Pregnancy: interferon alfa		*** Pregnancy: [[interferon alfa]]
	** If >1.5m platelets, requires cytoreduction alone		** If >1.5m platelets, requires cytoreduction alone

Aidan: Text replacement - "Clinical Presentation" to "Clinical Manifestations"

2020-07-19T17:07:06Z

Text replacement - "Clinical Presentation" to "Clinical Manifestations"

← Older revision		Revision as of 17:07, 19 July 2020
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	* Must distinguish from other myelodysplastic disorders (especially polycythemia vera) as well as from secondary causes of thrombocytosis		* Must distinguish from other myelodysplastic disorders (especially polycythemia vera) as well as from secondary causes of thrombocytosis

	== Clinical ~~Presentation~~ ==		== Clinical Manifestations ==

	* History		* History

Maintenance script: Imported from text file

2020-07-04T01:17:34Z

Imported from text file

New page

== Definition ==

* Myelodysplastic disorder of the thrombocytopoeitic stem cells causing a clonal proliferation of thrombocytes

== Differential Diagnosis ==

* Must distinguish from other myelodysplastic disorders (especially polycythemia vera) as well as from secondary causes of thrombocytosis

== Clinical Presentation ==

* History
** History of thrombosis or bleeding
* Signs & Symptoms
** Digital ischemia
** Cerebrovascular ischemia
* High risk for vascular events if:
** History of thrombosis or bleeding
** Increased cardiovascular risk
** Older than 60 years

== Management ==

* Acute
** If digital or cerebrovascular ischemia, rapid cytoreduction with plateletpheresis
* Chronic
** If high risk, requires cytoreduction and aspirin:
*** First-line: hydroxyurea
*** Alternative: anagrelide
*** Pregnancy: interferon alfa
** If >1.5m platelets, requires cytoreduction alone

[[Category:Hematology]]