Entamoeba histolytica - Revision history

Aidan: /* Diagnosis */

2023-10-07T13:43:59Z

Diagnosis

← Older revision		Revision as of 13:43, 7 October 2023
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	*Microscopically indistinguishable from the non-pathogenic ''E. dispar'', so needs molecular tests to confirm diagnosis		*Microscopically indistinguishable from the non-pathogenic ''E. dispar'', so needs molecular tests to confirm diagnosis
			*On aspiration, the fluid is classically odorless, thick, yellow-brown liquid, described as "anchovy paste"

	==Management==		==Management==

Aidan at 19:45, 10 February 2023

2023-02-10T19:45:27Z

← Older revision		Revision as of 19:45, 10 February 2023
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	==Management==		==Management==

			=== Diarrhea or Dysentery ===
			*Either
		⚫	**[[Is treated by::Metronidazole]] 750 mg p.o. tid for 5 to 10 days
			**[[Is treated by::Tinidazole]] 2 g PO daily for 3-5 days
		⚫	*Followed by a luminal agent, as below
	===Liver Abscess===		===Liver Abscess===

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	**[[Is treated with::Metronidazole]] 750 mg PO tid for 10 days, or		**[[Is treated with::Metronidazole]] 750 mg PO tid for 10 days, or
	**[[Is treated with::Tinidazole]] 2 g PO daily for 5 days		**[[Is treated with::Tinidazole]] 2 g PO daily for 5 days
	*Followed by a luminal agent~~, either~~		*Followed by a luminal agent:
	**[[Is treated by::Paramomycin]] 10 mg~~/kg~~ PO tid for ~~5 to 10~~ days~~, or~~		**[[Is treated by::Paramomycin]] 500 mg p.o. tid for 7 days
	**[[Is treated by::~~Diloxanide furoate~~]] ~~500~~ mg PO tid for 10 days		**[[Is treated by::Iodoquinol]] 650 mg p.o. tid for 20 days
			**[[Is treated by::Diloxanide furoate]] 500 mg p.o. tid for 10 days
	*May need surgery or aspiration if the lesion is large or medication has failed		*May need surgery or aspiration if the lesion is large or medication has failed

	===~~Diarrhea~~===		===Asymptomatic Carriage===

		⚫	*Treat with a luminal agent, as above
⚫	*[[Is treated by::~~Tinidazole~~]] 2 g PO ~~daily~~ for 5 days
⚫	*Followed by a luminal agent, as ~~above~~

			=== Treatments in Canada ===
	===Asymptomatic carriage===

			* Metronidazole, iodoquinol, and paromomycin are all available in Canada
⚫	*Treat with a luminal agent, as above

	{{DISPLAYTITLE:''Entamoeba histolytica''}}
			== Further Reading ==

			* Adrienne J. Showler, Andrea K. Boggild. Entamoeba histolytica. <abbr>''CMAJ''</abbr> Sep 2013, 185 (12) 1064; '''DOI:''' [https://doi.org/10.1503/cmaj.121576 10.1503/cmaj.121576]{{DISPLAYTITLE:''Entamoeba histolytica''}}
	[[Category:Protozoa]]		[[Category:Protozoa]]

Aidan: /* Amoebic Liver Abscess */

2020-09-16T23:54:50Z

Amoebic Liver Abscess

← Older revision		Revision as of 23:54, 16 September 2020
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	**Right upper quadrant tenderness (75%), weight loss (40%), diarrhea (15-35%), cough (10%), and jaundice (10-15%)		**Right upper quadrant tenderness (75%), weight loss (40%), diarrhea (15-35%), cough (10%), and jaundice (10-15%)
	**The pain is typically a dull ache in the right upper quadrant or epigastrium		**The pain is typically a dull ache in the right upper quadrant or epigastrium
			*More likely to present with abdominal pain and right upper quadrant tenderness than [[pyogenic liver abscess]]

	===Disseminated Amoebiasis===		===Disseminated Amoebiasis===

Aidan: /* Amoebic Liver Abscess */

2020-09-16T23:50:59Z

Amoebic Liver Abscess

← Older revision		Revision as of 23:50, 16 September 2020
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	*[[Causes::Amoebic liver abscess]] is far more common in men than women, and rare in children		*[[Causes::Amoebic liver abscess]] is far more common in men than women, and rare in children
	*Symptoms progress over 2 to 4 weeks, with fever, ~~cough,~~ and abdominal pain		*Symptoms progress over 2 to 4 weeks, with [[fever]] (80%) and [[abdominal pain]] (80%)
			**Right upper quadrant tenderness (75%), weight loss (40%), diarrhea (15-35%), cough (10%), and jaundice (10-15%)
	**The pain is typically a dull ache in the right upper quadrant or epigastrium		**The pain is typically a dull ache in the right upper quadrant or epigastrium

Aidan at 13:01, 24 August 2020

2020-08-24T13:01:15Z

Show changes

Aidan: Text replacement - "Clinical Presentation" to "Clinical Manifestations"

2020-07-16T15:05:52Z

Text replacement - "Clinical Presentation" to "Clinical Manifestations"

← Older revision		Revision as of 15:05, 16 July 2020
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	* Causes 34 to 50 million cases annually and up to 100,000 deaths		* Causes 34 to 50 million cases annually and up to 100,000 deaths

	== Clinical ~~Presentation~~ ==		== Clinical Manifestations ==
	=== Amoebic diarrhea and dysentery ===		=== Amoebic diarrhea and dysentery ===
	* [[Causes::Amoebic diarrhea]], with or without dysentery, is common		* [[Causes::Amoebic diarrhea]], with or without dysentery, is common

Aidan: /* Disseminated emoebiasis */

2020-06-30T18:26:26Z

Disseminated emoebiasis

← Older revision		Revision as of 18:26, 30 June 2020
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	** The pain is typically a dull ache in the right upper quadrant or epigastrium		** The pain is typically a dull ache in the right upper quadrant or epigastrium

	=== Disseminated ~~emoebiasis~~ ===		=== Disseminated amoebiasis ===
	* Metastatic infections are possible, most often from direct extension of a liver abscess		* Metastatic infections are possible, most often from direct extension of a liver abscess
	* Most commonly spreads to chest, with empyema, bronchohepatic fistula, pericarditis		* Most commonly spreads to chest, with empyema, bronchohepatic fistula, pericarditis

Aidan: /* Epidemiology */

2019-12-09T18:39:20Z

Epidemiology

← Older revision		Revision as of 18:39, 9 December 2019
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	=== Epidemiology ===		=== Epidemiology ===
			* Present worldwide, but most disease occurs in the developing world
	* Causes 34 to 50 million cases annually and up to 100,000 deaths		* Causes 34 to 50 million cases annually and up to 100,000 deaths

Aidan: added management

2019-12-09T18:37:47Z

added management

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 * Microscopically distinguishable from the non-pathogenic ''E. dispar'', so needs molecular tests to confirm diagnosis
 {{DISPLAYTITLE:''Entamoeba histolytica''}}
 [[Category:Protozoa]]

Aidan at 18:34, 9 December 2019

2019-12-09T18:34:15Z

← Older revision		Revision as of 18:34, 9 December 2019
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			== Background ==
			=== Microbiology ===
	* Intestinal protozoan parasite within the genus ''[[Entamoeba species\|Entamoeba]]''		* Intestinal protozoan parasite within the genus ''[[Entamoeba species\|Entamoeba]]''
			* Microscopically distinguishable from the non-pathogenic ''E. dispar'', ''E. moshkovskii'', and ''E. bangladeshii''
	* Causes amebic dysentery

			=== Epidemiology ===
			* Causes 34 to 50 million cases annually and up to 100,000 deaths

			== Clinical Presentation ==
			=== Amoebic diarrhea and dysentery ===
			* [[Causes::Amoebic diarrhea]], with or without dysentery, is common
			** About 15 to 30% of cases involve [[Causes::amoebic dysentery]] (with macroscopic or microscopic blood)
			* Typically a subacute onset over 3 to 4 weeks and abdominal pain
			** However, can be up to months
			* Fever is rare, even in dysentery
			* In children, can lead to intussusception, perforation, and necrotizing colitis

			=== Amoebic liver abscess ===
			* [[Causes::Amoebic liver abscess]] is far more common in men than women, and rare in children
			* Symptoms progress over 2 to 4 weeks, with fever, cough, and abdominal pain
			** The pain is typically a dull ache in the right upper quadrant or epigastrium

			=== Disseminated emoebiasis ===
			* Metastatic infections are possible, most often from direct extension of a liver abscess
			* Most commonly spreads to chest, with empyema, bronchohepatic fistula, pericarditis
			* Cerebral disease is rare but can happen

			== Diagnosis ==
	* Microscopically distinguishable from the non-pathogenic ''E. dispar'', so needs molecular tests to confirm diagnosis		* Microscopically distinguishable from the non-pathogenic ''E. dispar'', so needs molecular tests to confirm diagnosis