Echinococcus multilocularis - Revision history

Aidan: /* Clinical Manifestations */

2023-03-02T16:09:56Z

Clinical Manifestations

← Older revision		Revision as of 16:09, 2 March 2023
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	**May also mimic [[hepatocellular carcinoma]], [[cirrhosis]], and [[tuberculosis]]		**May also mimic [[hepatocellular carcinoma]], [[cirrhosis]], and [[tuberculosis]]
	**Causes continuously-growing tumour-like polycystic mass, made up of multiple vesicles that are lined by laminated germinal layer		**Causes continuously-growing tumour-like polycystic mass, made up of multiple vesicles that are lined by laminated germinal layer
	*Can cause cholestatic ~~jaundrice~~, cholangitis, portal hypertension, and Budd-Chiari syndrome		*Can cause cholestatic [[jaundice]], [[cholangitis]], [[portal hypertension]], and [[Budd-Chiari syndrome]]

	== Diagnosis ==		== Diagnosis ==

2022-10-13T18:03:08Z

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 ** Detection of ''E. multilocularis'' by serology
 ** OR detection of ''E. multilocularis'' by molecular diagnostic methods
 == Management ==

2022-05-04T16:16:53Z

Epidemiology

← Older revision		Revision as of 16:16, 4 May 2022
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	** Rare in North America		** Rare in North America
	* Within Canada:		* Within Canada:
			** Associated with arctic foxes and wolves
	** Alberta has highest number of cases, with 19 cases from 2013 to 2021		** Alberta has highest number of cases, with 19 cases from 2013 to 2021
	** 0 to 3 case reports in other provinces		** 0 to 3 case reports in other provinces

2021-11-23T21:01:25Z

Life Cycle

← Older revision		Revision as of 21:01, 23 November 2021
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	=== Life Cycle ===		=== Life Cycle ===

	* Definitive hosts are canid carnivorous animals		* Definitive hosts are canid carnivorous animals, including urban coyotes
	* Eggs contaminate the environment, including produce		* Eggs contaminate the environment, including produce
	** They are infective after a few days, and are viable for up to 16 months at 4ºC		** They are infective after a few days, and are viable for up to 16 months at 4ºC

2021-11-23T20:59:40Z

Diagnosis

← Older revision		Revision as of 20:59, 23 November 2021
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	*A single negative serologic test does not rule out infection		*A single negative serologic test does not rule out infection
	* May be confirmed by biopsy		* May be confirmed by biopsy

			=== Case Definition (Alberta) ===

			* Typical organ lesion detected by imaging with US or CT
			* AND histopathology compatible with alveolar echinococcosis
			* AND
			** Detection of ''E. multilocularis'' by serology
			** OR detection of ''E. multilocularis'' by molecular diagnostic methods

	== Management ==		== Management ==

2021-11-23T20:45:21Z

← Older revision		Revision as of 20:45, 23 November 2021
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	* Intermediate hosts (metacestode) are rodents, possibly pigs, and and incidentally humans		* Intermediate hosts (metacestode) are rodents, possibly pigs, and and incidentally humans
	* Intermediate host is eaten by the definitive host, completing the life cycle		* Intermediate host is eaten by the definitive host, completing the life cycle

			=== Epidemiology ===

			* Estimated 18,000 cases annually
			* Worldwide in the northern hemisphere
			** Most cases in China (90%), followed by Japan and Russia
			** Rare in North America
			* Within Canada:
			** Alberta has highest number of cases, with 19 cases from 2013 to 2021
			** 0 to 3 case reports in other provinces

	==Clinical Manifestations==		==Clinical Manifestations==
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	* Combination of radiologic and serologic investigations		* Combination of radiologic and serologic investigations
			*A single negative serologic test does not rule out infection
	* May be confirmed by biopsy		* May be confirmed by biopsy

2021-11-23T20:22:14Z

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 * Cestode in the [[Echinococcus]] family
 ==Clinical Manifestations==
-*Causes alveolar echinococcosis
+*Causes '''alveolar echinococcosis'''
 *Can cause cholestatic jaundrice, cholangitis, portal hypertension, and Budd-Chiari syndrome
 == Management ==

2021-09-21T14:32:23Z

Clinical Manifestations

← Older revision		Revision as of 14:32, 21 September 2021
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	*Causes alveolar echinococcosis		*Causes alveolar echinococcosis
	*Presents as a metastatic malignancy of unknown primary		*Presents as a metastatic malignancy of unknown primary, mot commonly with malaise, weight loss, and qight upper quadrant discomfort
	*May also mimic hepatic carcinoma, cirrhosis, and tuberculosis		**May also mimic hepatic carcinoma, cirrhosis, and tuberculosis
			*Can cause cholestatic jaundrice, cholangitis, portal hypertension, and Budd-Chiari syndrome
⚫	*Main treatment is surgical resection followed by at least 2 years of antihelminthic therapy

			== Management ==
		⚫	*Main treatment is surgical resection followed by at least 2 years of antihelminthic therapy (e.g. [[albendazole]])
	*Poor prognosis, with 90% 10-year mortality if untreated		*Poor prognosis, with 90% 10-year mortality if untreated

2020-08-04T01:13:25Z

← Older revision		Revision as of 01:13, 4 August 2020
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			{{DISPLAYTITLE:''Echinococcus multilocularis''}}
	#REDIRECT [[Echinococcus species#Alveolar_echinococcosis_.28E._multilocularis.29]]

			== Background ==

			=== Microbiology ===

			* Cestode in the [[Echinococcus]] family

			==Clinical Manifestations==

			*Causes alveolar echinococcosis
			*Presents as a metastatic malignancy of unknown primary
			*May also mimic hepatic carcinoma, cirrhosis, and tuberculosis
			*Main treatment is surgical resection followed by at least 2 years of antihelminthic therapy
			*Poor prognosis, with 90% 10-year mortality if untreated

			[[Category:Infectious diseases]]
			[[Category:Cestodes]]

2019-08-16T11:38:59Z

← Older revision		Revision as of 11:38, 16 August 2019
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	#REDIRECT [[Echinococcus species]]		#REDIRECT [[Echinococcus species#Alveolar_echinococcosis_.28E._multilocularis.29]]