Ebola virus - Revision history

Aidan at 12:53, 29 August 2020

2020-08-29T12:53:48Z

← Older revision		Revision as of 12:53, 29 August 2020
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	===Microbiology===		===Microbiology===

	*Negative-sense single-stranded RNA virus in the [[Filoviridae]] family		*Negative-sense single-stranded RNA virus in the [[Filoviridae]] family, related to [[Marburg virus]] and [[Cueva virus]]
	*The ebolavirus genus includes five species:		*The ebolavirus genus includes five species:
	**Zaire ebolavirus (EBOV), the most common		**Zaire ebolavirus (EBOV), the most common
	**Bundibugyo ebolavirus (BDBV)		**Bundibugyo ebolavirus (BDBV)
	**Reston ebolavirus (RESTV)		**Reston ebolavirus (RESTV), which does not cause disease in humans
	**Sudan ebolavirus (SUDV)		**Sudan ebolavirus (SUDV)
	**Taï Forest (or Cote d'Ivoire) ebolavirus (TAFV)		**Taï Forest (or Cote d'Ivoire) ebolavirus (TAFV)
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	*Essentially located exclusively in west Africa		*Essentially located exclusively in west Africa
	*Outbreaks occur where there is food insecurity (with resultant hunting for bush meat), increased population density, and insufficient public health infrastructure		*Outbreaks occur where there is food insecurity (with resultant hunting for bush meat), increased population density, and insufficient public health infrastructure
			*Human-to-human transmission occurs via exposure to contaminated blood or fluids, including providing care to infected family or patient and preparing an infected body for funeral
			*Mainly infectious during symptoms, which corresponds to viremia

	==Clinical Manifestations==		==Clinical Manifestations==
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	==Prevention==		==Prevention==

	=== Vaccination ===		===Vaccination===

	*Vaccination with a recombinant vesicular stomatitis virus that has its glycoprotein replaced by Ebola virus glycoprotein		*Vaccination with a recombinant vesicular stomatitis virus that has its glycoprotein replaced by Ebola virus glycoprotein
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	**>100,000 doses give		**>100,000 doses give

	=== Infection Prevention and Control ===		===Infection Prevention and Control===

	* Isolate patient		*Isolate patient
	* Droplet precautions and face protection within 1 meter of patient		*Droplet precautions and face protection within 1 meter of patient
	* Limit hospital staff who have contact		*Limit hospital staff who have contact

	[[Category:Filoviridae]]		[[Category:Filoviridae]]

Aidan: /* Prevention */

2020-08-28T13:42:13Z

Prevention

← Older revision		Revision as of 13:42, 28 August 2020
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	==Background==		==Background==

	=== Microbiology ===		===Microbiology===

	*Negative-sense single-stranded RNA virus in the [[Filoviridae]] family		*Negative-sense single-stranded RNA virus in the [[Filoviridae]] family
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	**Taï Forest (or Cote d'Ivoire) ebolavirus (TAFV)		**Taï Forest (or Cote d'Ivoire) ebolavirus (TAFV)

	=== Epidemiology ===		===Epidemiology===

	* Essentially located exclusively in west Africa		*Essentially located exclusively in west Africa
	* Outbreaks occur where there is food insecurity (with resultant hunting for bush meat), increased population density, and insufficient public health infrastructure		*Outbreaks occur where there is food insecurity (with resultant hunting for bush meat), increased population density, and insufficient public health infrastructure

	==Clinical Manifestations==		==Clinical Manifestations==
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	*Hiccups associated with increased mortality		*Hiccups associated with increased mortality

	== Diagnosis ==		==Diagnosis==

	* Ensure to notify the lab before sending samples, and contact Public Health for instructions		*Ensure to notify the lab before sending samples, and contact Public Health for instructions
	** [[Biosafety risk groups\|Biosafety level 4 agent]]		**[[Biosafety risk groups\|Biosafety level 4 agent]]
	* qPCR at the Public Health Laboratory Ontario, but only for Zaire ebolavirus		*qPCR at the Public Health Laboratory Ontario, but only for Zaire ebolavirus
	* Canada's National Microbiology Laboratory does RT-PCR, viral isolation, and serology		*Canada's National Microbiology Laboratory does RT-PCR, viral isolation, and serology

	== Management ==		==Management==

	* Supportive care alone can decrease mortality to 20-30%		*Supportive care alone can decrease mortality to 20-30%
	* Monoclonal antibodies		*Monoclonal antibodies
	** REGN-EB3 (6% mortality)		**REGN-EB3 (6% mortality)
	** mAb-114 (11% mortality)		**mAb-114 (11% mortality)
	** Zmapp (24% mortality)		**Zmapp (24% mortality)
	* Medications		*Medications
	** [[Remdesivir]] (33% mortality)		**[[Remdesivir]] (33% mortality)

	== Prevention ==		==Prevention==

			=== Vaccination ===
⚫	* Vaccination with a recombinant vesicular stomatitis virus that has its glycoprotein replaced by Ebola virus glycoprotein

⚫	** Used in large West African and DRC outbreaks with ring vaccination
		⚫	*Vaccination with a recombinant vesicular stomatitis virus that has its glycoprotein replaced by Ebola virus glycoprotein
⚫	** Efficacy 95-100%
		⚫	**Used in large West African and DRC outbreaks with ring vaccination
⚫	** >100,000 doses give
		⚫	**Efficacy 95-100%
		⚫	**>100,000 doses give

			=== Infection Prevention and Control ===

			* Isolate patient
			* Droplet precautions and face protection within 1 meter of patient
			* Limit hospital staff who have contact

	[[Category:Filoviridae]]		[[Category:Filoviridae]]

Aidan at 13:31, 28 August 2020

2020-08-28T13:31:56Z

@@ Line 1: / Line 1: @@
-==Microbiology==
+==Background==
 *Negative-sense single-stranded RNA virus in the [[Filoviridae]] family
@@ Line 8: / Line 10: @@
 **Sudan ebolavirus (SUDV)
 **Taï Forest (or Cote d'Ivoire) ebolavirus (TAFV)
 ==Clinical Manifestations==
 *Incubation period [[Incubation period range::2 to 21 days]] (generally [[Usual incubation period::3 to 13 days]])
-*Fever, fatigue, myalgias, weakness, and dizziness
+*Initially starts as a non-specific influenza-like illness with fever, fatigue, myalgias, weakness, and dizziness
 *EBOV can persist after resolution of symptoms in privileged sites: the eyes, CNS, male reproductive tract, and mammary glands
 *Relapse can occur as uveitis or meningitis
 [[Category:Filoviridae]]

Aidan at 13:15, 28 August 2020

2020-08-28T13:15:50Z

← Older revision		Revision as of 13:15, 28 August 2020
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	== Microbiology ==		==Microbiology==

	* Negative-sense single-stranded RNA virus in the Filoviridae family		*Negative-sense single-stranded RNA virus in the [[Filoviridae]] family
			*The ebolavirus genus includes five species:
			**Zaire ebolavirus (EBOV), the most common
			**Bundibugyo ebolavirus (BDBV)
			**Reston ebolavirus (RESTV)
			**Sudan ebolavirus (SUDV)
			**Taï Forest (or Cote d'Ivoire) ebolavirus (TAFV)

	== Clinical Manifestations ==		==Clinical Manifestations==

	* Incubation period [[Incubation period range::2 to 21 days]] (generally [[Usual incubation period::3 to 13 days]])		*Incubation period [[Incubation period range::2 to 21 days]] (generally [[Usual incubation period::3 to 13 days]])
	* Fever, fatigue, myalgias, weakness, and dizziness		*Fever, fatigue, myalgias, weakness, and dizziness
	* EBOV can persist after resolution of symptoms in privileged sites: the eyes, CNS, male reproductive tract, and mammary glands		*EBOV can persist after resolution of symptoms in privileged sites: the eyes, CNS, male reproductive tract, and mammary glands
	* Relapse can occur as uveitis or meningitis		*Relapse can occur as uveitis or meningitis

			=== Prognosis and Complications ===

			* 33 to 75% mortality, depending mostly on supportive care

	[[Category:Filoviridae]]		[[Category:Filoviridae]]

Aidan: /* Clinical Manifestations */

2020-08-05T13:36:52Z

Clinical Manifestations

← Older revision		Revision as of 13:36, 5 August 2020
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	== Clinical Manifestations ==		== Clinical Manifestations ==

	* Incubation period 2 to 21 days (generally 3 to 13 days)		* Incubation period [[Incubation period range::2 to 21 days]] (generally [[Usual incubation period::3 to 13 days]])
	* Fever, fatigue, myalgias, weakness, and dizziness		* Fever, fatigue, myalgias, weakness, and dizziness
	* EBOV can persist after resolution of symptoms in privileged sites: the eyes, CNS, male reproductive tract, and mammary glands		* EBOV can persist after resolution of symptoms in privileged sites: the eyes, CNS, male reproductive tract, and mammary glands

Aidan: Text replacement - "Clinical Presentation" to "Clinical Manifestations"

2020-07-14T23:29:06Z

Text replacement - "Clinical Presentation" to "Clinical Manifestations"

← Older revision		Revision as of 23:29, 14 July 2020
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	* Negative-sense single-stranded RNA virus in the Filoviridae family		* Negative-sense single-stranded RNA virus in the Filoviridae family

	== Clinical ~~Presentation~~ ==		== Clinical Manifestations ==

	* Incubation period 2 to 21 days (generally 3 to 13 days)		* Incubation period 2 to 21 days (generally 3 to 13 days)

Aidan at 15:06, 17 August 2019

2019-08-17T15:06:46Z

← Older revision		Revision as of 15:06, 17 August 2019
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	= Microbiology =		== Microbiology ==

	* Negative-sense single-stranded RNA virus in the Filoviridae family		* Negative-sense single-stranded RNA virus in the Filoviridae family

	= Clinical Presentation =		== Clinical Presentation ==

	* Incubation period 2 to 21 days (generally 3 to 13 days)		* Incubation period 2 to 21 days (generally 3 to 13 days)

Aidan at 23:39, 14 August 2019

2019-08-14T23:39:05Z

← Older revision		Revision as of 23:39, 14 August 2019
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		⚫	= Microbiology =
	= Ebola virus (EBOV) =

⚫	== Microbiology ==

	* Negative-sense single-stranded RNA virus in the Filoviridae family		* Negative-sense single-stranded RNA virus in the Filoviridae family

	== Clinical Presentation ==		= Clinical Presentation =

	* Incubation period 2 to 21 days (generally 3 to 13 days)		* Incubation period 2 to 21 days (generally 3 to 13 days)
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	* EBOV can persist after resolution of symptoms in privileged sites: the eyes, CNS, male reproductive tract, and mammary glands		* EBOV can persist after resolution of symptoms in privileged sites: the eyes, CNS, male reproductive tract, and mammary glands
	* Relapse can occur as uveitis or meningitis		* Relapse can occur as uveitis or meningitis

			[[Category:Filoviridae]]

Aidan: Aidan moved page RNA Ebola virus (EBOV) to Ebola virus without leaving a redirect

2019-08-14T23:38:11Z

Aidan moved page RNA Ebola virus (EBOV) to Ebola virus without leaving a redirect

← Older revision		Revision as of 23:38, 14 August 2019
(No difference)

Maintenance script: Imported from text file

2019-08-11T18:05:56Z

Imported from text file

New page

= Ebola virus (EBOV) =

== Microbiology ==

* Negative-sense single-stranded RNA virus in the Filoviridae family

== Clinical Presentation ==

* Incubation period 2 to 21 days (generally 3 to 13 days)
* Fever, fatigue, myalgias, weakness, and dizziness
* EBOV can persist after resolution of symptoms in privileged sites: the eyes, CNS, male reproductive tract, and mammary glands
* Relapse can occur as uveitis or meningitis