https://idwiki.org/index.php?action=history&feed=atom&title=Durvalumab 2026-04-28T23:26:38Z Revision history for this page on the wiki MediaWiki 1.43.8 https://idwiki.org/index.php?title=Durvalumab&diff=10381&oldid=prev 2024-02-07T19:43:46Z

<p>Created page with &quot;* Human IgG1k monoclonal antibody that blocks PD-L1 from interacting PD-1 and CD-80 * Indicated for <a href="/index.php?title=Urothelial_carcinoma&amp;action=edit&amp;redlink=1" class="new" title="Urothelial carcinoma (page does not exist)">urothelial carcinoma</a>, <a href="/Small_cell_lung_cancer" title="Small cell lung cancer">small cell lung cancer</a>, <a href="/index.php?title=Non-small_cell_lung_cancer&amp;action=edit&amp;redlink=1" class="new" title="Non-small cell lung cancer (page does not exist)">non-small cell lung cancer</a> * Adverse effects include ** Cardiac: <a href="/Hypertension" title="Hypertension">hypertension</a> (6%), <a href="/Myocarditis" title="Myocarditis">myocarditis</a> (rare) ** Dermatologic: rash with pruritus (22%) ** Gastrointestinal: abdominal pain (10%), anorexia (14%), constipation (12%), diarrhea (18%), colitis (2%), nausea/vomiting (14%) ** General: edema (8%), fatigue (...&quot;</p> <p><b>New page</b></p><div>* Human IgG1k monoclonal antibody that blocks PD-L1 from interacting PD-1 and CD-80<br /> * Indicated for [[urothelial carcinoma]], [[small cell lung cancer]], [[non-small cell lung cancer]]<br /> * Adverse effects include<br /> ** Cardiac: [[hypertension]] (6%), [[myocarditis]] (rare)<br /> ** Dermatologic: rash with pruritus (22%)<br /> ** Gastrointestinal: abdominal pain (10%), anorexia (14%), constipation (12%), diarrhea (18%), colitis (2%), nausea/vomiting (14%)<br /> ** General: edema (8%), fatigue (24%)<br /> ** Hematologic: [[immune-mediated thrombocytopenic purpura]] (rare)<br /> ** Hepatobiliary: elevated liver tests (6%), hepatitis (2%), pancreatitis (rare)<br /> ** Hypersensitivity: infusion reactions (2%)<br /> ** Infection (26%): [[UTI]] and [[pneumonia]] most commonly<br /> ** Metabolic: adrenal insufficiency (rare), diabetes mellitus (rare), hyperthyroidism (8%), hypophysitis (rare), hypothyroidism (12%), thyroiditis (2%)<br /> ** MSK: pain (12%)<br /> ** CNS: aseptic meningitis or encephalitis (rare), headache (11%), insomnia (10%)<br /> ** Ophthalmic: [[uveitis]] (rare)<br /> ** Renal: increased creatinine (5%)<br /> ** Respiratory: cough or dyspnea (40%), severe cough or dyspnea (1%), dysphonia (4%), pneumonitis (3%, but up to 34% in NSCLC)<br /> <br /> [[Category:Monoclonal antibodies]]<br /> [[Category:Oncology]]</div>

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