https://idwiki.org/index.php?action=history&feed=atom&title=Down_syndrome
Down syndrome - Revision history
2026-05-12T23:39:12Z
Revision history for this page on the wiki
MediaWiki 1.43.8
https://idwiki.org/index.php?title=Down_syndrome&diff=7342&oldid=prev
Aidan at 00:56, 17 November 2020
2020-11-17T00:56:35Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 00:56, 17 November 2020</td>
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<td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>*Most common chromosomal disorder<ins style="font-weight: bold; text-decoration: none;">, occurring in 1:800 live births</ins></div></td>
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<td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>*<del style="font-weight: bold; text-decoration: none;"> </del>Most common genetic cause of mental impairment</div></td>
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<td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>* <del style="font-weight: bold; text-decoration: none;">Characteristic</del> facial features, <del style="font-weight: bold; text-decoration: none;">including</del> flat facial profile, oblique palpebral fissures, and epicanthic folds</div></td>
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<td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>*<ins style="font-weight: bold; text-decoration: none;">Presents</ins> <ins style="font-weight: bold; text-decoration: none;">at birth with hypotonia, short neck, single palmar crease and characteristic</ins> facial features, <ins style="font-weight: bold; text-decoration: none;">which include</ins> flat facial profile, oblique palpebral fissures, and epicanthic folds</div></td>
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<td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>*Increased risk of<ins style="font-weight: bold; text-decoration: none;"> leukemia, including</ins> [[<ins style="font-weight: bold; text-decoration: none;">acute lymphoblastic leukemia]] and [[acute myeloid leukemia</ins>]]</div></td>
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Aidan
https://idwiki.org/index.php?title=Down_syndrome&diff=7312&oldid=prev
Aidan: Created page with "== Background == === Epidemiology === * Most common chromosomal disorder * Most common genetic cause of mental impairment === Pathophysiology === * Trisomy 21, most common..."
2020-11-06T18:00:40Z
<p>Created page with "== Background == === Epidemiology === * Most common chromosomal disorder * Most common genetic cause of mental impairment === Pathophysiology === * Trisomy 21, most common..."</p>
<p><b>New page</b></p><div>== Background ==<br />
<br />
=== Epidemiology ===<br />
<br />
* Most common chromosomal disorder<br />
* Most common genetic cause of mental impairment<br />
<br />
=== Pathophysiology ===<br />
<br />
* Trisomy 21, most commonly caused by meiotic non-disjunction<br />
<br />
== Clinical Manifestations ==<br />
<br />
* Characteristic facial features, including flat facial profile, oblique palpebral fissures, and epicanthic folds<br />
* Half will have [[congenital heart disease]]<br />
* Increased risk of leukemia, including [[acute lymphoblastic leukemia]] and [[acute myeloid leukemia]]<br />
* Increased risk of [[pneumonia]]<br />
* Early [[Alzheimer disease]] starting around age 40 years<br />
* Median age of death is 47 years<br />
<br />
[[Category:Pediatrics]]</div>
Aidan