Dosing of antimicrobials in obesity - Revision history

Aidan: /* Tetracyclines */

2026-01-27T18:38:04Z

Tetracyclines

← Older revision		Revision as of 18:38, 27 January 2026
Line 169:		Line 169:
	\|-		\|-
	\| [[Doxycycline]]		\| [[Doxycycline]]
	\| Usual dose		\| colspan="2" \| Usual dose
	\| Usual dose
	\|		\|
	\|-		\|-
	\| [[Tigecycline]]		\| [[Tigecycline]]
	\| Usual dose		\| colspan="2" \| Usual dose
	\| Usual dose
	\|		\|
	\|}		\|}

Aidan: /* Tetracyclines */

2026-01-27T18:37:43Z

Tetracyclines

@@ Line 167: / Line 167: @@
 {| class="wikitable" style="width:100%"
 ! Drug !! Usual Dose !! Obesity !! Notes
 |}

Aidan at 18:10, 27 October 2025

2025-10-27T18:10:51Z

@@ Line 1: / Line 1: @@
-== Calculating Body Weight ==
+== Background ==
 Weight-based dosing can use total body weight (TBW) in some instances, but often requires adjustments.
@@ Line 30: / Line 34: @@
 |}
-== Calculating CrCl ==
+=== Calculating CrCl ===
 == Antibiotics ==
 === β-lactams ===
 ==== Penicillins ====
@@ Line 244: / Line 252: @@
 | Use TBW; or 25-30 mg/kg load and 15 mg/kg q12h with ABW<sub>0.4</sub>
+|
 |}

Aidan at 17:50, 27 October 2025

2025-10-27T17:50:59Z

← Older revision		Revision as of 17:50, 27 October 2025
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	\| '''[https://www.mdcalc.com/ideal-body-weight-adjusted-body-weight Adjusted body weight]''' (ABW) (kg)		\| '''[https://www.mdcalc.com/ideal-body-weight-adjusted-body-weight Adjusted body weight]''' (ABW) (kg)
	\| <math>IBW + C \times (TBW - IBW)</math>		\| <math>IBW + C \times (TBW - IBW)</math>
	\| C = 0.3 to 0.4		\| C = 0.3 to 0.4 or more; drug-specific
	\|-		\|-
	\| rowspan=2 \| '''Lean body weight''' (LBW) (kg)		\| rowspan=2 \| '''Lean body weight''' (LBW) (kg)

Aidan at 17:35, 27 October 2025

2025-10-27T17:35:54Z

← Older revision		Revision as of 17:35, 27 October 2025
Line 14:		Line 14:
	\|-		\|-
	\| rowspan=2 \| '''[https://www.mdcalc.com/ideal-body-weight-adjusted-body-weight Ideal body weight]''' (IBW) (kg)		\| rowspan=2 \| '''[https://www.mdcalc.com/ideal-body-weight-adjusted-body-weight Ideal body weight]''' (IBW) (kg)
	\| male: <math>50 + 2.3 \times ~~\small{~~\text{(inches over 5 ft)}}</math>		\| male: <math>50 + 2.3 \times \text{(inches over 5 ft)}</math>
	\| rowspan=2 \| in inches		\| rowspan=2 \| in inches
	\|-		\|-
	\| female: <math>45.5 + 2.3 \times ~~\small{~~\text{(inches over 5 ft)}}</math>		\| female: <math>45.5 + 2.3 \times \text{(inches over 5 ft)}</math>
	\|-		\|-
	\| '''[https://www.mdcalc.com/ideal-body-weight-adjusted-body-weight Adjusted body weight]''' (ABW) (kg)		\| '''[https://www.mdcalc.com/ideal-body-weight-adjusted-body-weight Adjusted body weight]''' (ABW) (kg)

Aidan at 18:47, 23 October 2025

2025-10-23T18:47:44Z

← Older revision		Revision as of 18:47, 23 October 2025
Line 84:		Line 84:
	\| 2 g IV q8h prolonged infusion		\| 2 g IV q8h prolonged infusion
	\|		\|
			\|-
			\|[[Ceftriaxone]]
			\|1-2 g IV q24h
			\|2 g IV q12h
			\|
	\|-		\|-
	\| [[Ceftazidime-avibactam]]		\| [[Ceftazidime-avibactam]]
Line 243:		Line 248:
	== Further Reading ==		== Further Reading ==
	* Comprehensive Guidance for Antibiotic Dosing in Obese Adults. ''Pharmacotherapy''. 2017;37(11):1415-1431. doi: [https://doi.org/10.1002/phar.2023 10.1002/phar.2023]		* Comprehensive Guidance for Antibiotic Dosing in Obese Adults. ''Pharmacotherapy''. 2017;37(11):1415-1431. doi: [https://doi.org/10.1002/phar.2023 10.1002/phar.2023]
			* Updated antimicrobial dosing recommendations for obese patients. ''Antimicrob Agents Chemother''. 2024;68(5):e0171923. doi: [https://doi.org/10.1128/aac.01719-23 10.1128/aac.01719-23]

	[[Category:Antimicrobials]]		[[Category:Antimicrobials]]

Aidan: /* Cephalosporins */

2023-06-08T16:36:40Z

Cephalosporins

← Older revision		Revision as of 16:36, 8 June 2023
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	\| [[Cefazolin]]		\| [[Cefazolin]]
	\| 1-2 g IV q8h		\| 1-2 g IV q8h
	\| 2-3 g IV ~~q6-8h~~ once ≥120 kg		\| 2 g IV q6h once ≥120 kg
	\|		\|
	\|-		\|-

Aidan: /* Calculating Body Weight */

2020-07-20T14:22:44Z

Calculating Body Weight

← Older revision		Revision as of 14:22, 20 July 2020
Line 2:		Line 2:
	Weight-based dosing can use total body weight (TBW) in some instances, but often requires adjustments.		Weight-based dosing can use total body weight (TBW) in some instances, but often requires adjustments.

	{\| class="wikitable~~" style="width:100%~~"		{\| class="wikitable"
	! Statistic !! Equation !! Notes		! Statistic !! Equation !! Notes
	\|-		\|-

Aidan at 14:22, 20 July 2020

2020-07-20T14:22:33Z

← Older revision		Revision as of 14:22, 20 July 2020
Line 2:		Line 2:
	Weight-based dosing can use total body weight (TBW) in some instances, but often requires adjustments.		Weight-based dosing can use total body weight (TBW) in some instances, but often requires adjustments.

	{\| class="wikitable"		{\| class="wikitable" style="width:100%"
	! Statistic !! Equation !! Notes		! Statistic !! Equation !! Notes
	\|-		\|-
Line 37:		Line 37:
	==== Penicillins ====		==== Penicillins ====

	{\| class="wikitable"		{\| class="wikitable" style="width:100%"
	! Drug !! Usual Dose !! Obesity !! Notes		! Drug !! Usual Dose !! Obesity !! Notes
	\|-		\|-
Line 62:		Line 62:

	==== Cephalosporins ====		==== Cephalosporins ====
	{\| class="wikitable"		{\| class="wikitable" style="width:100%"
	! Drug !! Usual Dose !! Obesity !! Notes		! Drug !! Usual Dose !! Obesity !! Notes
	\|-		\|-
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	==== Carbapenems ====		==== Carbapenems ====
	{\| class="wikitable"		{\| class="wikitable" style="width:100%"
	! Drug !! Usual Dose !! Obesity !! Notes		! Drug !! Usual Dose !! Obesity !! Notes
	\|-		\|-
Line 127:		Line 127:

	=== Quinolones ===		=== Quinolones ===
	{\| class="wikitable"		{\| class="wikitable" style="width:100%"
	! Drug !! Usual Dose !! Obesity !! Notes		! Drug !! Usual Dose !! Obesity !! Notes
	\|-		\|-
Line 147:		Line 147:

	=== Macrolides ===		=== Macrolides ===
	{\| class="wikitable"		{\| class="wikitable" style="width:100%"
	! Drug !! Usual Dose !! Obesity !! Notes		! Drug !! Usual Dose !! Obesity !! Notes
	\|}		\|}

	=== Tetracyclines ===		=== Tetracyclines ===
	{\| class="wikitable"		{\| class="wikitable" style="width:100%"
	! Drug !! Usual Dose !! Obesity !! Notes		! Drug !! Usual Dose !! Obesity !! Notes
	\|}		\|}

	=== Aminoglycosides ===		=== Aminoglycosides ===
	{\| class="wikitable"		{\| class="wikitable" style="width:100%"
	! Drug !! Usual Dose !! Obesity !! Notes		! Drug !! Usual Dose !! Obesity !! Notes
	\|-		\|-
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	=== Others ===		=== Others ===
	{\| class="wikitable"		{\| class="wikitable" style="width:100%"
	! Drug !! Usual Dose !! Obesity !! Notes		! Drug !! Usual Dose !! Obesity !! Notes
	\|-		\|-

Aidan: /* Calculating CrCl */

2020-06-15T22:29:02Z

Calculating CrCl

← Older revision		Revision as of 22:29, 15 June 2020
Line 31:		Line 31:

	== Calculating CrCl ==		== Calculating CrCl ==
	Salazer ~~and Cocorn~~ equation is more reliable in obesity.		[https://globalrph.com/medcalcs/salazar-corcoran-calc/ Salazer-Cocoran equation] is more reliable in obesity but requires both height and weight.

	== Antibiotics ==		== Antibiotics ==