Dapsone - Revision history

Aidan: /* Dosing */

2021-03-03T13:15:32Z

Dosing

← Older revision		Revision as of 13:15, 3 March 2021
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	===Indications===		===Indications===

	*Second-line ~~PJP~~ prophylaxis (CD4 <200)		*Second-line [[Pneumocystis jirovecii]] prophylaxis (CD4 <200)
	*~~Rifampicin~~ and clofazimine as multidrug therapy (MDT) for the treatment of ''Mycobacterium leprae''		*Along with [[rifampicin]] and [[clofazimine]] as multidrug therapy (MDT) for the treatment of ''[[Mycobacterium leprae]]''

	==Dosing==		==Dosing==

	*'''Dermatitis herpetiformis:'''		*'''[[Dermatitis herpetiformis]]'''
	**Start at 50 mg PO daily, increase to 300 mg daily in 25 mg increments every 1 to 2 weeks, up to 2 mg/kg/dose		**Start at 50 mg PO daily, increase to 300 mg daily in 25 mg increments every 1 to 2 weeks, up to 2 mg/kg/dose
	**Pruritus usually improves within 72 hours, and the skin manifestations typically resolve within days		**Pruritus usually improves within 72 hours, and the skin manifestations typically resolve within days
	**After 2-3 months of gluten-free diet, start tapering by 25 mg every four to six weeks		**After 2-3 months of gluten-free diet, start tapering by 25 mg every four to six weeks
	*'''~~PJP~~ prophylaxis (primary or secondary):'''		*'''[[Pneumocystis]] prophylaxis (primary or secondary)'''
	**100 mg PO once daily or in 2 divided doses as monotherapy		**100 mg PO once daily or in 2 divided doses as monotherapy
	**Continue until CD4 count >200 cells/mm3 for >3 months		**Continue until CD4 count >200 cells/mm3 for >3 months
	*'''~~PJP~~ treatment:''' 100 mg PO once daily in combination with [[trimethoprim]] for 21 days		*'''[[Pneumocystis]] treatment:''' 100 mg PO once daily in combination with [[trimethoprim]] for 21 days

	== Safety ==		==Safety==

	* Check CBC, liver, and G6PD deficiency before starting		*Check CBC, liver, and G6PD deficiency before starting

	[[Category:Antibiotics]]		[[Category:Antibiotics]]

Aidan: /* Dosing */

2021-03-03T13:14:32Z

Dosing

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-== Background ==
+==Background==
 *Diamino-diphenyl sulfone
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 *Rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of ''Mycobacterium leprae''
-== Dosing ==
+==Dosing==
 [[Category:Antibiotics]]

Aidan at 13:11, 3 March 2021

2021-03-03T13:11:23Z

← Older revision		Revision as of 13:11, 3 March 2021
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			== Background ==
⚫	* Diamino-diphenyl sulfone

		⚫	*Diamino-diphenyl sulfone
⚫	== Indications ==

		⚫	===Indications===
⚫	* Second-line PJP prophylaxis (CD4 <200)

⚫	* Rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of ''Mycobacterium leprae''
		⚫	*Second-line PJP prophylaxis (CD4 <200)
		⚫	*Rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of ''Mycobacterium leprae''

			== Dosing ==

			* '''Dermatitis herpetiformis:''' Start at 50 mg PO daily, increase to 300 mg daily, or higher to achieve full control, reduce to minimum maintenance dosage as soon as possible
			* '''PJP prophylaxis (primary or secondary):'''
			** 100 mg PO once daily or in 2 divided doses as monotherapy
			** Continue until CD4 count >200 cells/mm3 for >3 months
			* '''PJP treatment:''' 100 mg PO once daily in combination with [[trimethoprim]] for 21 days

	[[Category:Antibiotics]]		[[Category:Antibiotics]]

Aidan at 09:59, 16 August 2019

2019-08-16T09:59:19Z

← Older revision		Revision as of 09:59, 16 August 2019
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	= Dapsone =

	* Diamino-diphenyl sulfone		* Diamino-diphenyl sulfone

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	* Second-line PJP prophylaxis (CD4 <200)		* Second-line PJP prophylaxis (CD4 <200)
	* Rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of ''Mycobacterium leprae''		* Rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of ''Mycobacterium leprae''

			[[Category:Antibiotics]]

Maintenance script: Imported from text file

2019-08-11T17:58:17Z

Imported from text file

New page

= Dapsone =

* Diamino-diphenyl sulfone

== Indications ==

* Second-line PJP prophylaxis (CD4 <200)
* Rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of ''Mycobacterium leprae''