Cystic fibrosis antibiotic dosing - Revision history

Aidan at 15:29, 20 June 2023

2023-06-20T15:29:07Z

← Older revision		Revision as of 15:29, 20 June 2023
Line 1:		Line 1:
	{\| class="wikitable sortable"		{\| class="wikitable sortable"
	! Medication		! Medication
			!Coverage
	! Dose		! Dose
	! Frequency
	! Home IV
	\|-		\|-
	\| [[Aztreonam]]		\| [[Aztreonam]]
			\|[[Burkholderia cepacia]], [[Pseudomonas aeruginosa]]
	\| 2 g
	\| q8h		\| 2 g IV q8h
	\| no
	\|-		\|-
	\| [[Cefazolin]]		\| [[Cefazolin]]
			\|[[Staphylococcus aureus]]
	\| 2 g
	\| q8h		\| 2 g IV q8h
	\| yes
	\|-		\|-
	\| [[Cefipime]]		\| [[Cefipime]]
			\|[[Burkholderia cepacia]], [[Pseudomonas aeruginosa]]
	\| 2 g
	\| q8h		\| 2 g IV q8h
	\| yes
	\|-		\|-
	\| [[Ceftazidime]]		\| [[Ceftazidime]]
			\|[[Achromobacter]], [[Burkholderia cepacia]], [[Pseudomonas aeruginosa]]
	\| 2 g
			\| 2-3 g IV q6-8h (max 12 g/day)
	\| q8h
			\|-
	\| yes
			\|[[Ceftazidime-avibactam]]
			\|[[Pseudomonas aeruginosa]]
			\|2.5 g IV q8h
	\|-		\|-
	\| [[Chloramphenicol]]		\| [[Chloramphenicol]]
			\|[[Achromobacter]], [[Burkholderia cepacia]]
	\| 500 mg to 1 g
			\| 12.5-25 mg/kg/dose IV q6h (max 1g/dose) with drug monitoring to target peak 10-20 mcg/mL and trough 5-10 mcg/mL
	\| q6h
	\| at SMH
	\|-		\|-
	\| [[Ciprofloxacin]]		\| [[Ciprofloxacin]]
			\|[[Achromobacter]], [[Pseudomonas aeruginosa]]
	\| 400 mg
			\| 400 mg IV q8h or 750 mg p.o. BID to TID
	\| q8h
	\| yes
	\|-		\|-
	\| [[Cloxacillin]]		\| [[Cloxacillin]]
			\|[[Staphylococcus aureus]]
	\| 2 g
	\| q6h		\| 1-2 g IV q6h
	\| yes
	\|-		\|-
	\| [[Colistin]]		\| [[Colistin]]
			\|[[Achromobacter]], [[Pseudomonas aeruginosa]]
	\| 75 mg
			\| 2.5-5 mg/kg/day divided q8-12h (max 5 mg/kg/day)
	\| q8-12h
	\| yes
	\|-		\|-
	\| [[Meropenem]]		\| [[Meropenem]]
			\|[[Achromobacter]], [[Burkholderia cepacia]], [[Pseudomonas aeruginosa]]
	\| 2 g
	\| q8h		\| 2 g IV q8h
	\| CADD pump
	\|-		\|-
	\| [[Piperacillin/tazobactam]]		\| [[Piperacillin/tazobactam]]
			\|[[Achromobacter]], [[Pseudomonas aeruginosa]]
	\| 4.5 g		\| 4.5 g IV q4-6h
	\| q6-8h
	\| yes
	\|-		\|-
	\| [[Tigecycline]]		\| [[Tigecycline]]
			\|[[Achromobacter]], [[MRSA]], [[NTM]], [[Stenotrophomonas maltophilia]]
	\| 100 mg load, then 50 mg		\| 100 mg IV load, then 50 mg IV q12h
	\| q12h
	\| no
	\|-		\|-
	\| [[Tobramycin]]		\| [[Tobramycin]]
			\|[[Pseudomonas aeruginosa]]
	\| 10 mg/kg
			\| 10 mg/kg/dose IV q24h with drug monitoring to target peak 20-40 mg/L and trough <1 mg/L
	\| q24h
	\| yes
	\|-		\|-
	\| [[Vancomycin]]		\| [[Vancomycin]]
			\|[[MRSA]]
	\| 1 g
			\| 15-20 mg/kg/dose IV q8-12h to target trough 15-20 mg/L; or 15-20 mg/kg IV load then 30-40 mg/kg/day (max 60 mg/kg/day) IV continuous infusion, target steady state level 20-25 mg/L
	\| q8h
	\| yes
	\|}		\|}

			Source: [https://www.cysticfibrosis.ca/uploads/Antibiotic%20Dosing%20Guideline%20Aug%202021.pdf CF Canada]
	'''Source:''' St. Michael's Hospital

	[[Category:Infectious diseases]]		[[Category:Infectious diseases]]

Aidan at 15:19, 20 June 2023

2023-06-20T15:19:45Z

← Older revision		Revision as of 15:19, 20 June 2023
Line 1:		Line 1:
			{\| class="wikitable sortable"
	{\|
	! Medication		! Medication
	! Dose		! Dose
Line 5:		Line 5:
	! Home IV		! Home IV
	\|-		\|-
	\| Aztreonam		\| [[Aztreonam]]
	\| 2 g		\| 2 g
	\| q8h		\| q8h
	\| no		\| no
	\|-		\|-
	\| Cefazolin		\| [[Cefazolin]]
	\| 2 g		\| 2 g
	\| q8h		\| q8h
	\| yes		\| yes
	\|-		\|-
	\| Cefipime		\| [[Cefipime]]
	\| 2 g		\| 2 g
	\| q8h		\| q8h
	\| yes		\| yes
	\|-		\|-
	\| Ceftazidime		\| [[Ceftazidime]]
	\| 2 g		\| 2 g
	\| q8h		\| q8h
	\| yes		\| yes
	\|-		\|-
	\| Chloramphenicol		\| [[Chloramphenicol]]
	\| 500 mg to 1 g		\| 500 mg to 1 g
	\| q6h		\| q6h
	\| at SMH		\| at SMH
	\|-		\|-
	\| Ciprofloxacin		\| [[Ciprofloxacin]]
	\| 400 mg		\| 400 mg
	\| q8h		\| q8h
	\| yes		\| yes
	\|-		\|-
	\| Cloxacillin		\| [[Cloxacillin]]
	\| 2 g		\| 2 g
	\| q6h		\| q6h
	\| yes		\| yes
	\|-		\|-
	\| Colistin		\| [[Colistin]]
	\| 75 mg		\| 75 mg
	\| q8-12h		\| q8-12h
	\| yes		\| yes
	\|-		\|-
	\| Meropenem		\| [[Meropenem]]
	\| 2 g		\| 2 g
	\| q8h		\| q8h
	\| CADD pump		\| CADD pump
	\|-		\|-
			\| [[Piperacillin/tazobactam]]
	\| Pip/tazo
	\| 4.5 g		\| 4.5 g
	\| q6-8h		\| q6-8h
	\| yes		\| yes
	\|-		\|-
	\| Tigecycline		\| [[Tigecycline]]
	\| 100 mg load, then 50 mg		\| 100 mg load, then 50 mg
	\| q12h		\| q12h
	\| no		\| no
	\|-		\|-
	\| Tobramycin		\| [[Tobramycin]]
	\| 10 mg/kg		\| 10 mg/kg
	\| q24h		\| q24h
	\| yes		\| yes
	\|-		\|-
	\| Vancomycin		\| [[Vancomycin]]
	\| 1 g		\| 1 g
	\| q8h		\| q8h

Maintenance script: Imported from text file

2020-07-04T01:17:29Z

Imported from text file

New page

{|
! Medication
! Dose
! Frequency
! Home IV
|-
| Aztreonam
| 2 g
| q8h
| no
|-
| Cefazolin
| 2 g
| q8h
| yes
|-
| Cefipime
| 2 g
| q8h
| yes
|-
| Ceftazidime
| 2 g
| q8h
| yes
|-
| Chloramphenicol
| 500 mg to 1 g
| q6h
| at SMH
|-
| Ciprofloxacin
| 400 mg
| q8h
| yes
|-
| Cloxacillin
| 2 g
| q6h
| yes
|-
| Colistin
| 75 mg
| q8-12h
| yes
|-
| Meropenem
| 2 g
| q8h
| CADD pump
|-
| Pip/tazo
| 4.5 g
| q6-8h
| yes
|-
| Tigecycline
| 100 mg load, then 50 mg
| q12h
| no
|-
| Tobramycin
| 10 mg/kg
| q24h
| yes
|-
| Vancomycin
| 1 g
| q8h
| yes
|}

'''Source:''' St. Michael's Hospital

[[Category:Infectious diseases]]
[[Category:Respirology]]