Creutzfeldt-Jakob disease - Revision history

Aidan: /* Prevention */

2024-04-10T16:39:50Z

Prevention

← Older revision		Revision as of 16:39, 10 April 2024
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	====Risk Assessment====		====Risk Assessment====

			*'''Patient risk of transmission'''
	*'''High-risk patients''': confirmed, probable, or possible CJD, familial CJD, GSS, or FFI, undiagnosed rapidly-progressive dementia, or asymptomatic carrier of a genetic transmissible spongiform encephalopathy		**'''High-risk patients''': confirmed, probable, or possible CJD, familial CJD, GSS, or FFI, undiagnosed rapidly-progressive dementia, or asymptomatic carrier of a genetic transmissible spongiform encephalopathy
	*'''At-risk patients''': recipients of human-derived pituitary hormones, dura mater grafts (until 1992 for Lyodura or 1997 for Tutoplast Dura grafts), or corneal graft from jurisdiction that does not screen for neurological diseases; or patients who have been exposed to high-infectivity tissue/instruments of a confirmed case of CJD		**'''At-risk patients''': recipients of human-derived pituitary hormones, dura mater grafts (until 1992 for Lyodura or 1997 for Tutoplast Dura grafts), or corneal graft from jurisdiction that does not screen for neurological diseases; or patients who have been exposed to high-infectivity tissue/instruments of a confirmed case of CJD
	*'''Tissue risk of transmission'''		*'''Tissue risk of transmission'''
	**'''High''' (>50%): brain~~, CSF~~, dura mater, pituitary gland, posterior eye (optic nerve and retina), spinal cord, spinal ganglia, trigeminal ganglia		**'''High''' (>50%): brain, dura mater, pituitary gland, posterior eye (optic nerve and retina), spinal cord, spinal ganglia, trigeminal ganglia
	**'''Low''' (10-20%, though no reported human cases): cornea, kidney, liver, lung, lymph nodes, placenta, spleen		**'''Low''' (10-20%, though no reported human cases): CSF, cornea, kidney, liver, lung, lymph nodes, placenta, spleen
	**'''None''' (0%): adipose tissue, adrenal gland, appendix, blood, cord blood, blood vessels, bone marrow, breast milk, dental pulp, epididymis, esophagus, feces, gingival tissue, heart, ileum, jejunum, large intestine, nasal mucosa, nasal mucous, ovaries, pancreas, pericardium, peripheral nerves, placental fluid, prostate, saliva, semen, seminal vesicle, skeletal muscle, skin, sweat, tears, testis, thymus, thyroid gland, tongue, tonsil, trachea, urine, uterus		**'''None''' (0%): adipose tissue, adrenal gland, appendix, blood, cord blood, blood vessels, bone marrow, breast milk, dental pulp, epididymis, esophagus, feces, gingival tissue, heart, ileum, jejunum, large intestine, nasal mucosa, nasal mucous, ovaries, pancreas, pericardium, peripheral nerves, placental fluid, prostate, saliva, semen, seminal vesicle, skeletal muscle, skin, sweat, tears, testis, thymus, thyroid gland, tongue, tonsil, trachea, urine, uterus

Aidan at 17:38, 18 January 2024

2024-01-18T17:38:19Z

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 ==Clinical Manifestations==
 {| class="wikitable"
 !Feature

Aidan: /* Diagnosis */

2022-10-11T15:12:29Z

Diagnosis

← Older revision		Revision as of 15:12, 11 October 2022
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	* Before sending samples, contact the Canadian CJD Surveillance Coordination Office (phone: 1-888-489-2999)		* Before sending samples, contact the Canadian CJD Surveillance Coordination Office (phone: 1-888-489-2999)
	* Review IPAC guidelines under ~~[[Creutzfeldt-Jakob disease#~~Prevention~~\|Prevention]]~~, below		* Review IPAC guidelines under Prevention, below

	===CSF===		===CSF===

Aidan: /* Diagnosis */

2022-10-11T15:11:56Z

Diagnosis

← Older revision		Revision as of 15:11, 11 October 2022
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	==Diagnosis==		==Diagnosis==

			* Before sending samples, contact the Canadian CJD Surveillance Coordination Office (phone: 1-888-489-2999)
			* Review IPAC guidelines under [[Creutzfeldt-Jakob disease#Prevention\|Prevention]], below

	===CSF===		===CSF===
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	*Following routine reprocessing		*Following routine reprocessing

			=== Lumbar Puncture ===

			* CSF specimen handling MUST be performed with increased safety precautions, wearing single use gloves, mask and gown within a BSC
			* CSF to be collected in leak-proof, puncture resistant primary container, placed in a biohazard bag
			* Package using the triple packaging system for transport to the appropriate laboratory section
			* Label as “CJD” for laboratory processing, decontamination and disposal

	==Further Reading==		==Further Reading==

Aidan: /* Diagnosis */

2021-09-01T14:00:58Z

Diagnosis

@@ Line 192: / Line 192: @@
 ===CSF===
-* CJD test panel includes: 14-3-3 protein, Tau protein, and PrPd (CJD-associated misfolded prion protein)
+* CJD test panel in Canada includes 14-3-3 protein, Tau protein, and quaking-induced conversion (QuIC)
 {| class="wikitable"
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 *<nowiki>** Standard threshold</nowiki>
 *CSF itself usually bland, non-inflammatory
 ===Imaging===

Aidan at 14:52, 5 November 2020

2020-11-05T14:52:34Z

Show changes

Aidan: Aidan moved page Creutzfeld-Jakob disease to Creutzfeldt-Jakob disease without leaving a redirect

2020-11-05T13:54:19Z

Aidan moved page Creutzfeld-Jakob disease to Creutzfeldt-Jakob disease without leaving a redirect

← Older revision	Revision as of 13:54, 5 November 2020
(No difference)

Aidan at 02:52, 5 November 2020

2020-11-05T02:52:46Z

@@ Line 10: / Line 10: @@
 ==Clinical Manifestations==
 ===Sporadic CJD (sCJD)===
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 *Akinetic mutism commonly develops 2–3 months after the onset of symptoms
 *Rapid or subacute decline, with a median survival 7-9 months from symptom onset
-*Can detect 14-3-3 protein in CSF
+*Can usually detect 14-3-3 protein in CSF
 *Can have a variety of subtypes, including visual, cerebellar, thalamic, or striatal-predominant symptoms
 ===Genetic CJD (gCJD)===
@@ Line 147: / Line 251: @@
 *Supportive care
 ==Prevention==

Aidan: /* Differential Diagnosis */

2020-11-05T02:18:17Z

Differential Diagnosis

← Older revision		Revision as of 02:18, 5 November 2020
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	==Differential Diagnosis==		==Differential Diagnosis==

		⚫	*[[Dementia with Lewy bodies]] (most common misdiagnosis)
	*[[Alzheimer dementia]]		*[[Alzheimer dementia]]
	*[[Vascular dementia]]		*[[Vascular dementia]]
	*[[Frontotemporal dementia]]		*[[Frontotemporal dementia]]
⚫	*[[Dementia with Lewy bodies]]
	*[[Parkinson disease]]		*[[Parkinson disease]]
	*[[Cerebral lymphoma]]		*[[Cerebral lymphoma]]

Aidan at 13:15, 29 October 2020

2020-10-29T13:15:23Z

← Older revision		Revision as of 13:15, 29 October 2020
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	[[Category:Prions]]		[[Category:Prions]]
	[[Category:Infectious diseases]]
	[[Category:Neurology]]		[[Category:Neurology]]