Congenital rubella - Revision history

Aidan at 23:24, 21 September 2020

2020-09-21T23:24:14Z

← Older revision		Revision as of 23:24, 21 September 2020
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	== Background ==		==Background==
⚫	=== Pathophysiology ===
⚫	* Transplacental transfer of [[rubella virus]] occurs during viremia, which peaks about 5 to 7 days following infection of mother
⚫	** Mother may be asymptomatic

			* Risk of transmission is 90% for mother's infected in the first trimester
⚫	== Clinical Manifestations ==
⚫	* Spectrum of disease, which includes [[Causes::intra-uterine fetal demise]], [[Causes::preterm delivery]], and the congenital rubella syndrome
⚫	* Severity depends in part on timing of infection
⚫	** Up to 8 weeks gestation: 20% chance of spontaneous abortion
⚫	** Up to 10 weeks: 90% chance of congenital rubella syndrome (severe defects)
⚫	** 13-18 weeks: 10-20% chance of hearing loss and retinopathy
⚫	** Congenital defects are unlikely if infection happens after 18 to 20 weeks gestation
⚫	** [[Causes::Intra-uterine growth restriction]] is likely only effect in third trimester
⚫	* Most children are asymptomatic at birth, but can develop signs and symptoms after several years

		⚫	===Pathophysiology===
⚫	=== Congenital Rubella Syndrome ===

⚫	* [[Causes::Sensorineural hearing loss]] (most common findings), blueberry muffin rash (from extramedullary hematopoiesis), [[Causes::cataracts]], [[Causes::glaucoma]], [[Causes::congenital heart disease]], and [[Causes::cognitive defects]]
		⚫	*Transplacental transfer of [[rubella virus]] occurs during viremia, which peaks about 5 to 7 days following infection of mother
⚫	* [[Causes::Low birth weight]], [[Causes::thrombocytopenic purpura]], [[Causes::hepatosplenomegaly]], [[Causes::meningoencephalitis]], [[Causes::retinopathy]], [[Causes::patent ductus arteriosus]], [[Causes::pulmonary stenosis]], developmental disorders, [[Causes::cryptorchidism]], inguinal hernia
		⚫	**Mother may be asymptomatic
⚫	* By the second decade of life, it can cause a progressing, fatal [[Causes::panencephalitis]]

		⚫	==Clinical Manifestations==

		⚫	*Spectrum of disease, which includes [[Causes::intra-uterine fetal demise]], [[Causes::preterm delivery]], and the congenital rubella syndrome
		⚫	*Severity depends in part on timing of infection
		⚫	**Up to 8 weeks gestation: 20% chance of spontaneous abortion
		⚫	**Up to 10 weeks: 90% chance of congenital rubella syndrome (severe defects)
		⚫	**13-18 weeks: 10-20% chance of hearing loss and retinopathy
		⚫	**Congenital defects are unlikely if infection happens after 18 to 20 weeks gestation
		⚫	**[[Causes::Intra-uterine growth restriction]] is likely only effect in third trimester
		⚫	*Most children are asymptomatic at birth, but can develop signs and symptoms after several years

		⚫	===Congenital Rubella Syndrome===

		⚫	*[[Causes::Sensorineural hearing loss]] (most common findings), blueberry muffin rash (from extramedullary hematopoiesis), [[Causes::cataracts]], [[Causes::glaucoma]], [[Causes::congenital heart disease]], and [[Causes::cognitive defects]]
		⚫	*[[Causes::Low birth weight]], [[Causes::thrombocytopenic purpura]], [[Causes::hepatosplenomegaly]], [[Causes::meningoencephalitis]], [[Causes::retinopathy]], [[Causes::patent ductus arteriosus]], [[Causes::pulmonary stenosis]], developmental disorders, [[Causes::cryptorchidism]], inguinal hernia
		⚫	*By the second decade of life, it can cause a progressing, fatal [[Causes::panencephalitis]]

	[[Category:Congenital infections]]		[[Category:Congenital infections]]

Aidan at 16:21, 20 September 2020

2020-09-20T16:21:24Z

← Older revision		Revision as of 16:21, 20 September 2020
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	* By the second decade of life, it can cause a progressing, fatal [[Causes::panencephalitis]]		* By the second decade of life, it can cause a progressing, fatal [[Causes::panencephalitis]]

	[[Category:Pediatrics]]
	[[Category:Congenital infections]]		[[Category:Congenital infections]]

Aidan at 18:17, 20 August 2020

2020-08-20T18:17:54Z

← Older revision		Revision as of 18:17, 20 August 2020
Line 21:		Line 21:
	[[Category:Pediatrics]]		[[Category:Pediatrics]]
	[[Category:Congenital infections]]		[[Category:Congenital infections]]
	[[Category:RNA viruses]]

Aidan: /* Congenital rubella syndrome */

2020-08-20T18:14:33Z

Congenital rubella syndrome

← Older revision		Revision as of 18:14, 20 August 2020
Line 14:		Line 14:
	* Most children are asymptomatic at birth, but can develop signs and symptoms after several years		* Most children are asymptomatic at birth, but can develop signs and symptoms after several years

	=== Congenital ~~rubella~~ ~~syndrome~~ ===		=== Congenital Rubella Syndrome ===
	* [[Causes::Sensorineural hearing loss]] (most common findings), blueberry muffin rash (from extramedullary hematopoiesis), [[Causes::cataracts]], [[Causes::glaucoma]], [[Causes::congenital heart disease]], and [[Causes::cognitive defects]]		* [[Causes::Sensorineural hearing loss]] (most common findings), blueberry muffin rash (from extramedullary hematopoiesis), [[Causes::cataracts]], [[Causes::glaucoma]], [[Causes::congenital heart disease]], and [[Causes::cognitive defects]]
	* [[Causes::Low birth weight]], [[Causes::thrombocytopenic purpura]], [[Causes::hepatosplenomegaly]], [[Causes::meningoencephalitis]], [[Causes::retinopathy]], [[Causes::patent ductus arteriosus]], [[Causes::pulmonary stenosis]], developmental disorders, [[Causes::cryptorchidism]], inguinal hernia		* [[Causes::Low birth weight]], [[Causes::thrombocytopenic purpura]], [[Causes::hepatosplenomegaly]], [[Causes::meningoencephalitis]], [[Causes::retinopathy]], [[Causes::patent ductus arteriosus]], [[Causes::pulmonary stenosis]], developmental disorders, [[Causes::cryptorchidism]], inguinal hernia
Line 20:		Line 20:

	[[Category:Pediatrics]]		[[Category:Pediatrics]]
			[[Category:Congenital infections]]
	[[Category:RNA viruses]]		[[Category:RNA viruses]]

Aidan: Text replacement - "Clinical Presentation" to "Clinical Manifestations"

2020-07-18T18:43:35Z

Text replacement - "Clinical Presentation" to "Clinical Manifestations"

← Older revision		Revision as of 18:43, 18 July 2020
Line 4:		Line 4:
	** Mother may be asymptomatic		** Mother may be asymptomatic

	== Clinical ~~Presentation~~ ==		== Clinical Manifestations ==
	* Spectrum of disease, which includes [[Causes::intra-uterine fetal demise]], [[Causes::preterm delivery]], and the congenital rubella syndrome		* Spectrum of disease, which includes [[Causes::intra-uterine fetal demise]], [[Causes::preterm delivery]], and the congenital rubella syndrome
	* Severity depends in part on timing of infection		* Severity depends in part on timing of infection

Aidan at 21:23, 9 February 2020

2020-02-09T21:23:39Z

← Older revision		Revision as of 21:23, 9 February 2020
Line 7:		Line 7:
	* Spectrum of disease, which includes [[Causes::intra-uterine fetal demise]], [[Causes::preterm delivery]], and the congenital rubella syndrome		* Spectrum of disease, which includes [[Causes::intra-uterine fetal demise]], [[Causes::preterm delivery]], and the congenital rubella syndrome
	* Severity depends in part on timing of infection		* Severity depends in part on timing of infection
	** ~~Infection~~ in ~~first~~ ~~trimester~~ ~~has~~ 80% chance of ~~defects~~		** Up to 8 weeks gestation: 20% chance of spontaneous abortion
			** Up to 10 weeks: 90% chance of congenital rubella syndrome (severe defects)
			** 13-18 weeks: 10-20% chance of hearing loss and retinopathy
	** Congenital defects are unlikely if infection happens after 18 to 20 weeks gestation		** Congenital defects are unlikely if infection happens after 18 to 20 weeks gestation
	** [[Causes::Intra-uterine growth restriction]] is likely only effect in third trimester		** [[Causes::Intra-uterine growth restriction]] is likely only effect in third trimester
	* Most children are asymptomatic at birth, but can develop signs and symptoms after several years		* Most children are asymptomatic at birth, but can develop signs and symptoms after several years

⚫	* [[Causes::~~Deafness~~]], [[Causes::cataracts]], [[Causes::glaucoma]], [[Causes::congenital heart disease]], and [[Causes::cognitive defects]]
			=== Congenital rubella syndrome ===
		⚫	* [[Causes::Sensorineural hearing loss]] (most common findings), blueberry muffin rash (from extramedullary hematopoiesis), [[Causes::cataracts]], [[Causes::glaucoma]], [[Causes::congenital heart disease]], and [[Causes::cognitive defects]]
	* [[Causes::Low birth weight]], [[Causes::thrombocytopenic purpura]], [[Causes::hepatosplenomegaly]], [[Causes::meningoencephalitis]], [[Causes::retinopathy]], [[Causes::patent ductus arteriosus]], [[Causes::pulmonary stenosis]], developmental disorders, [[Causes::cryptorchidism]], inguinal hernia		* [[Causes::Low birth weight]], [[Causes::thrombocytopenic purpura]], [[Causes::hepatosplenomegaly]], [[Causes::meningoencephalitis]], [[Causes::retinopathy]], [[Causes::patent ductus arteriosus]], [[Causes::pulmonary stenosis]], developmental disorders, [[Causes::cryptorchidism]], inguinal hernia
	* By the second decade of life, it can cause a progressing, fatal [[Causes::panencephalitis]]		* By the second decade of life, it can cause a progressing, fatal [[Causes::panencephalitis]]

Aidan: /* Pathophysiology */

2020-02-09T21:17:10Z

Pathophysiology

← Older revision		Revision as of 21:17, 9 February 2020
Line 1:		Line 1:
	== Background ==		== Background ==
	=== Pathophysiology ===		=== Pathophysiology ===
	* Transplacental transfer of [[~~Rubella~~ virus]] occurs during viremia, which peaks about 5 to 7 days following infection of mother		* Transplacental transfer of [[rubella virus]] occurs during viremia, which peaks about 5 to 7 days following infection of mother
			** Mother may be asymptomatic

	== Clinical Presentation ==		== Clinical Presentation ==

Aidan: /* Pathophysiology */

2020-02-09T01:44:09Z

Pathophysiology

← Older revision		Revision as of 01:44, 9 February 2020
Line 1:		Line 1:
	== Background ==		== Background ==
	=== Pathophysiology ===		=== Pathophysiology ===
	* Transplacental transfer of virus occurs during viremia, which peaks about 5 to 7 days following infection of mother		* Transplacental transfer of [[Rubella virus]] occurs during viremia, which peaks about 5 to 7 days following infection of mother

	== Clinical Presentation ==		== Clinical Presentation ==

Aidan: /* Clinical Presentation */

2020-02-09T01:43:51Z

Clinical Presentation

← Older revision		Revision as of 01:43, 9 February 2020
Line 1:		Line 1:
			== Background ==
			=== Pathophysiology ===
			* Transplacental transfer of virus occurs during viremia, which peaks about 5 to 7 days following infection of mother

	== Clinical Presentation ==		== Clinical Presentation ==
			* Spectrum of disease, which includes [[Causes::intra-uterine fetal demise]], [[Causes::preterm delivery]], and the congenital rubella syndrome
			* Severity depends in part on timing of infection
			** Infection in first trimester has 80% chance of defects
			** Congenital defects are unlikely if infection happens after 18 to 20 weeks gestation
			** [[Causes::Intra-uterine growth restriction]] is likely only effect in third trimester
			* Most children are asymptomatic at birth, but can develop signs and symptoms after several years
	* [[Causes::Deafness]], [[Causes::cataracts]], [[Causes::glaucoma]], [[Causes::congenital heart disease]], and [[Causes::cognitive defects]]		* [[Causes::Deafness]], [[Causes::cataracts]], [[Causes::glaucoma]], [[Causes::congenital heart disease]], and [[Causes::cognitive defects]]
	* [[Causes::Low birth weight]], [[Causes::thrombocytopenic purpura]], [[Causes::hepatosplenomegaly]], [[Causes::meningoencephalitis]], [[Causes::retinopathy]], ~~PDA~~, PS, developmental disorders, [[Causes::cryptorchidism]], inguinal hernia		* [[Causes::Low birth weight]], [[Causes::thrombocytopenic purpura]], [[Causes::hepatosplenomegaly]], [[Causes::meningoencephalitis]], [[Causes::retinopathy]], [[Causes::patent ductus arteriosus]], [[Causes::pulmonary stenosis]], developmental disorders, [[Causes::cryptorchidism]], inguinal hernia
			* By the second decade of life, it can cause a progressing, fatal [[Causes::panencephalitis]]

	[[Category:Pediatrics]]		[[Category:Pediatrics]]

Aidan: Created page with "== Clinical Presentation == * Causes::Deafness, Causes::cataracts, Causes::glaucoma, Causes::congenital heart disease, and Causes::cognitive defects * Ca..."

2020-02-09T01:28:52Z

Created page with "== Clinical Presentation == * Causes::Deafness, Causes::cataracts, Causes::glaucoma, Causes::congenital heart disease, and Causes::cognitive defects * Ca..."

New page

== Clinical Presentation ==
* [[Causes::Deafness]], [[Causes::cataracts]], [[Causes::glaucoma]], [[Causes::congenital heart disease]], and [[Causes::cognitive defects]]
* [[Causes::Low birth weight]], [[Causes::thrombocytopenic purpura]], [[Causes::hepatosplenomegaly]], [[Causes::meningoencephalitis]], [[Causes::retinopathy]], PDA, PS, developmental disorders, [[Causes::cryptorchidism]], inguinal hernia

[[Category:Pediatrics]]
[[Category:RNA viruses]]