Aidan at 16:11, 20 September 2020

2020-09-20T16:11:06Z

← Older revision		Revision as of 16:11, 20 September 2020
Line 11:		Line 11:
	{\| class="wikitable"		{\| class="wikitable"
	!Trimester		!Trimester
		⚫	!Congenital Anomaly
	!Any Microcephaly
⚫	!Congenital ~~Zika Syndrome~~
	\|-		\|-
	\|first		\|first
	\|10%		\|8-13%
	\|7%
	\|-		\|-
	\|second		\|second
	\|3%		\|3-5%
	\|1%
	\|-		\|-
	\|third		\|third
	\|4%		\|3-5%
	\|1%
	\|-		\|-
	\|overall		\|overall
	\|6%		\|5-10%
	\|3%
	\|}		\|}

Aidan at 16:08, 20 September 2020

2020-09-20T16:08:41Z

Show changes

Aidan: Created page with "== Background == * Infection with Zika virus * Mostly transmitted by mosquitoes (mainly Aedes aegypti), but can be sexually transmitted * Present in most of South and..."

2020-09-20T13:47:15Z

Created page with "== Background == * Infection with Zika virus * Mostly transmitted by mosquitoes (mainly Aedes aegypti), but can be sexually transmitted * Present in most of South and..."

New page

== Background ==

* Infection with [[Zika virus]]
* Mostly transmitted by mosquitoes (mainly [[Aedes aegypti]]), but can be sexually transmitted
* Present in most of South and Central America including the Caribbean, sub-Saharan Africa, the Indian subcontinent, southeast Asia, and the Pacific islands
* Transmission
** Detectable in serum of pregnant women for 10 weeks after symptom onset
** Detectable in semen for up to 188 days after symptom onset (but only 69 days for replication-competent virus)
*** Longest documented duration from symptom onset to sexual transmission is 32 to 41 days

== Clinical Manifestations ==

* Cranial morphology due to a disruption in the fetal brain sequence
** Severe [[microcephaly]]
** Overlapping cranial sutures
** Prominent occipital bone
** Redundant scalp skin
* Brain anomalies
** Diffuse [[CNS calcifications in neonates|CNS calcifications]], primarily subcortical
** [[Ventriculomegaly]]
** [[Polymicrogyria]] with cortical thinning
** Hypoplasia of the corpus callosum
** Decreased myelination
** Hypoplasia of the cerebellar vermis
* Ocular anomalies (25 to 55%)
** Chorioretinal atrophy or scarring
** Focal pigmentary retinal mottling
** Optic nerve atrophy
** Microphthalmia, cataracts, and intraocular calcifications
* Congenital contractures (5 to 15%)
** [[Arthrogryposis]]
** [[Club foot]]
** Congenital hip dislocation
** Other contractures, usually bilateral

== Diagnosis ==

* Testing is only indicated for returned travellers with compatible symptoms
** CATMAT recommends against routine testing of asymptomatic pregnant women
* Molecular testing is the mainstay of diagnosis
* Serology also possible

== Prevention ==

* For asymptomatic men and women: no recommendations
* For women who have confirmed infection: wait 2 months after returning from the risk area before trying to conceive
* For men who have confirmed infection: wait 3 months after returning from the risk area before trying to conceive
* For men with compatible symptoms or confirmed infection and a pregnant partner: use barrier protection for the duration of pregnancy

== Further Reading ==

* [https://www.canada.ca/en/public-health/services/publications/diseases-conditions/zika-virus-prevention-treatment-recommendations.html CATMAT Zika Virus Prevention and Treatment Recommendations]

Congenital Zika - Revision history

Aidan at 16:11, 20 September 2020

Aidan at 16:08, 20 September 2020

Aidan: Created page with "== Background == * Infection with Zika virus * Mostly transmitted by mosquitoes (mainly Aedes aegypti), but can be sexually transmitted * Present in most of South and..."