https://idwiki.org/index.php?action=history&feed=atom&title=Clofazimine 2026-04-28T23:10:07Z Revision history for this page on the wiki MediaWiki 1.43.8 https://idwiki.org/index.php?title=Clofazimine&diff=10140&oldid=prev 2023-08-24T13:36:29Z

<p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 13:36, 24 August 2023</td> </tr><tr> <td colspan="2" class="diff-lineno">Line 4:</td> <td colspan="2" class="diff-lineno">Line 4:</td> </tr> <tr> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Indicated for [[leprosy]] and [[non-tuberculous mycobacteria]]</div></td> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Indicated for [[leprosy]] and [[non-tuberculous mycobacteria]]</div></td> </tr> <tr> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Has never been studied in an RCT</div></td> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Has never been studied in an RCT</div></td> </tr> <tr> <td class="diff-marker" data-marker="−"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>* Mechanism of action is postulated to be redox cycling and <del style="font-weight: bold; text-decoration: none;">memrane</del> destabilization and dysfunction</div></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* Mechanism of action is<ins style="font-weight: bold; text-decoration: none;"> unknown, but</ins> postulated to be redox cycling and <ins style="font-weight: bold; text-decoration: none;">membrane</ins> destabilization and dysfunction</div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><br /></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>== Dosing ==</div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><br /></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* Multibacillary leprosy: 50 mg p.o. once daily (in combination with other medications)</div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* Erythema nodosum leprosum: 100 mg p.o. 3 times daily for 12 weeks, then twice daily for 12 weeks, then once daily for 12 to 24 weeks (+/- prednisolone)</div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* Non-tuberculous mycobacteria: 100 to 200 mg p.o. once daily (in combination with other medications)</div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* Tuberculosis: 100 mg p.o. once daily (in combination with other medications)</div></td> </tr> <tr> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td> </tr> <tr> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Safety ==</div></td> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Safety ==</div></td> </tr> <!-- diff cache key site7_mediawiki:diff:1.41:old-10139:rev-10140:wikidiff2=table:1.13.0:bc2a06be --> </table>

Aidan https://idwiki.org/index.php?title=Clofazimine&diff=10139&oldid=prev 2023-08-24T13:32:38Z

<p>Created page with &quot;== Background == * Antibiotic * Indicated for <a href="/Leprosy" class="mw-redirect" title="Leprosy">leprosy</a> and <a href="/Non-tuberculous_mycobacteria" title="Non-tuberculous mycobacteria">non-tuberculous mycobacteria</a> * Has never been studied in an RCT * Mechanism of action is postulated to be redox cycling and memrane destabilization and dysfunction == Safety == === Adverse Effects === * Skin darkening: exposure-related, onset is gradual. Not permanent, will slowly resolve after stopping the drug. * Dry skin and generalized pruritus * QT prolongation and possibly <a href="/index.php?title=Torsades_de_pointes&amp;action=edit&amp;redlink=1" class="new" title="Torsades de pointes (page does not exist)">torsades de pointes</a>...&quot;</p> <p><b>New page</b></p><div>== Background ==<br /> <br /> * Antibiotic<br /> * Indicated for [[leprosy]] and [[non-tuberculous mycobacteria]]<br /> * Has never been studied in an RCT<br /> * Mechanism of action is postulated to be redox cycling and memrane destabilization and dysfunction<br /> <br /> == Safety ==<br /> <br /> === Adverse Effects ===<br /> <br /> * Skin darkening: exposure-related, onset is gradual. Not permanent, will slowly resolve after stopping the drug.<br /> * Dry skin and generalized pruritus<br /> * QT prolongation and possibly [[torsades de pointes]]<br /> * Crystal deposition in liver, spleen, and lymph nodes, usually presenting as worsening abdominal pain<br /> <br /> [[Category:Antibiotics]]</div>

Aidan