Cladophialophora - Revision history

Aidan at 20:53, 27 January 2022

2022-01-27T20:53:35Z

← Older revision		Revision as of 20:53, 27 January 2022
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	** [[Is treated by::Isavuconazole]] has very promising responses in CNS infections, though limited data[[CiteRef::schwartz2019is]]		** [[Is treated by::Isavuconazole]] has very promising responses in CNS infections, though limited data[[CiteRef::schwartz2019is]]

	{{DISPLAYTITLE:''Cladophialophora'' ~~species~~}}		{{DISPLAYTITLE:''Cladophialophora''}}
	[[Category:Dematiaceous molds]]		[[Category:Dematiaceous molds]]

Aidan: Aidan moved page Cladophialophora species to Cladophialophora without leaving a redirect: Text replacement - " species$" to ""

2022-01-27T20:51:42Z

Aidan moved page Cladophialophora species to Cladophialophora without leaving a redirect: Text replacement - " species$" to ""

← Older revision		Revision as of 20:51, 27 January 2022
(No difference)

Aidan: Text replacement - "Clinical Presentation" to "Clinical Manifestations"

2020-07-14T20:20:12Z

Text replacement - "Clinical Presentation" to "Clinical Manifestations"

← Older revision		Revision as of 20:20, 14 July 2020
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	* Unclear if acquired by inhalation or implantation		* Unclear if acquired by inhalation or implantation

	== Clinical ~~Presentation~~ ==		== Clinical Manifestations ==
	* Certain species may present as [[fungal brain abscess]]		* Certain species may present as [[fungal brain abscess]]

Aidan: Major revision

2019-11-03T19:43:43Z

Major revision

← Older revision		Revision as of 19:43, 3 November 2019
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⚫	== Background ==
	* Includes ''[[Cladophialophora bantiana]]'' and ''[[Cladophialophora modesta]]'', which are neurotropic and cause CNS disease		* Includes ''[[Cladophialophora bantiana]]'' and ''[[Cladophialophora modesta]]'', which are neurotropic and cause CNS disease
	* Other ''Cladophialophora'' species may cause mild cutaneous lesions to disseminated disease.		* Other ''Cladophialophora'' species may cause mild cutaneous lesions to disseminated disease.

		⚫	== Background ==
			=== Microbiology ===
			* ''[[Cladophialophora bantiana]]'' and ''[[Cladophialophora modesta]]'', which cause [[fungal brain abscesses]]
			* ''[[Cladophialophora arxii]]'', ''[[Cladophialophora emmonsii]]'', and ''[[Cladophialophora modesta]]'' can cause brain abscess as well as non-CNS disease
			* ''[[Cladophialophora carionii]]'' causes [[chromoblastomycosis]]
			* Many non-pathogenic species, which can be laboratory contaminants

	=== Epidemiology ===		=== Epidemiology ===
	* More common in India		* More common in India
			* Associated with soil, bark, or carbon-rich environments, like coal mining or sawdust
			* More common in gardeners and farmers, but not exclusive
			* Unclear if acquired by inhalation or implantation

			== Clinical Presentation ==
			* Certain species may present as [[fungal brain abscess]]

	== Diagnosis ==		== Diagnosis ==
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	* [[Is treated by::Amphotericin B]], [[Is treated by::flucytosine]], [[Is treated by::caspofungin]] and [[Is treated by::terbinafine]], or an extended spectrum triazole may be tried when surgical resection is not possible		* [[Is treated by::Amphotericin B]], [[Is treated by::flucytosine]], [[Is treated by::caspofungin]] and [[Is treated by::terbinafine]], or an extended spectrum triazole may be tried when surgical resection is not possible
	** For ''[[Cladophialophora bantiana]]'' infections, the combination of the three drugs ([[Is treated by::flucytosine]], [[Is treated by::micafungin]] and [[Is treated by::posaconazole]]) is recommended based on a mouse model[[CiteRef::mariné2009co]]		** For ''[[Cladophialophora bantiana]]'' infections, the combination of the three drugs ([[Is treated by::flucytosine]], [[Is treated by::micafungin]] and [[Is treated by::posaconazole]]) is recommended based on a mouse model[[CiteRef::mariné2009co]]
			** [[Is treated by::Isavuconazole]] has very promising responses in CNS infections, though limited data[[CiteRef::schwartz2019is]]

	{{DISPLAYTITLE:''Cladophialophora'' species}}		{{DISPLAYTITLE:''Cladophialophora'' species}}

Aidan: Initial page creation

2019-11-02T19:34:44Z

Initial page creation

New page

== Background ==
* Includes ''[[Cladophialophora bantiana]]'' and ''[[Cladophialophora modesta]]'', which are neurotropic and cause CNS disease
* Other ''Cladophialophora'' species may cause mild cutaneous lesions to disseminated disease.

=== Epidemiology ===
* More common in India

== Diagnosis ==
* Culture
** Microscopy
*** Long, delicate, branching chains of hydrophobic brown conidia and lacking yeast cells, with brown septate hyphae
** The species (and ''Cladosporium'') are differentiated by physiologic tests include temperature tolerance, gelatin liquefaction, cycloheximide growth, urease test, and the nitrate test
* Histopathology is necessary for subcutaneous infections

== Management ==
* Surgical resection is recommended when possible
* CNS disease may not respond to antifungal therapy
* [[Is treated by::Amphotericin B]], [[Is treated by::flucytosine]], [[Is treated by::caspofungin]] and [[Is treated by::terbinafine]], or an extended spectrum triazole may be tried when surgical resection is not possible
** For ''[[Cladophialophora bantiana]]'' infections, the combination of the three drugs ([[Is treated by::flucytosine]], [[Is treated by::micafungin]] and [[Is treated by::posaconazole]]) is recommended based on a mouse model[[CiteRef::mariné2009co]]

{{DISPLAYTITLE:''Cladophialophora'' species}}
[[Category:Dematiaceous molds]]