Ciguatera - Revision history

Aidan: Text replacement - " species]]" to "]]"

2022-01-25T16:38:00Z

Text replacement - " species]]" to "]]"

← Older revision		Revision as of 16:38, 25 January 2022
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	===Pathophysiology===		===Pathophysiology===

	*[[Gambierdiscus ~~species~~]] dinoflagellates that live on or around coral make ciguatera toxin, which concentrates in the fish		*[[Gambierdiscus]] dinoflagellates that live on or around coral make ciguatera toxin, which concentrates in the fish
	*Toxin is heat-stable, acid-stable, and lipid-soluble		*Toxin is heat-stable, acid-stable, and lipid-soluble

Aidan: /* Clinical Manifestations */

2020-09-19T20:34:05Z

Clinical Manifestations

← Older revision		Revision as of 20:34, 19 September 2020
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	*Neurological symptoms develop within 3 to 72 hours of ingestion, and include [[Causes::hot-cold reversal]], [[Causes::cold allodynia]], and [[Causes::paresthesias]]		*Neurological symptoms develop within 3 to 72 hours of ingestion, and include [[Causes::hot-cold reversal]], [[Causes::cold allodynia]], and [[Causes::paresthesias]]
	**Can last for weeks to months in a minority of cases		**Can last for weeks to months in a minority of cases
			*Concomitant alcohol consumption portends a higher risk of developing [[bradycardia]], [[hypotension]], and altered sensation

	==Investigations==		==Investigations==

Aidan: /* Clinical Manifestations */

2020-09-19T20:31:45Z

Clinical Manifestations

← Older revision		Revision as of 20:31, 19 September 2020
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	== Background ==		==Background==

	*Foodborne illness caused by eating reef fish that have concentrated ciguatoxin		*Foodborne illness caused by eating reef fish that have concentrated ciguatoxin
	*Barracuda and moray eel are classic, but also amberjack, grouper, snapper, and parrotfish, and, rarely, farm-raised salmon		*Barracuda and moray eel are classic, but also amberjack, grouper, snapper, and parrotfish, and, rarely, farm-raised salmon

	=== Pathophysiology ===		===Pathophysiology===

	* [[Gambierdiscus species]] dinoflagellates that live on or around coral make ciguatera toxin, which concentrates in the fish		*[[Gambierdiscus species]] dinoflagellates that live on or around coral make ciguatera toxin, which concentrates in the fish
	* Toxin is heat-stable, acid-stable, and lipid-soluble		*Toxin is heat-stable, acid-stable, and lipid-soluble

	== Clinical Manifestations ==		==Clinical Manifestations==

	*Incubation period of [[Usual incubation period::3 to 6 hours]] (range [[Incubation period range::up to 30 hours]])		*Incubation period of [[Usual incubation period::3 to 6 hours]] (range [[Incubation period range::up to 30 hours]])
	*Can present with a variety of symptoms, including gastrointestinal, neurologic, and cardiovascular		*Can present with a variety of symptoms, including gastrointestinal, neurologic, and cardiovascular
	*GI symptoms develop within 3 to 6 hours, and include [[Causes::nausea]], [[Causes::vomiting]], [[Causes:diarrhea]], and [[Causes::abdominal pain]]		*GI symptoms develop within 3 to 6 hours, and include [[Causes::nausea]], [[Causes::vomiting]], [[Causes::diarrhea]], and [[Causes::abdominal pain]]
	**Can take up to 4 days to resolve		**Can take up to 4 days to resolve
	*Cardiovascular symptoms develop within a few hours, and include [[Causes::bradycardia]], [[Causes::heart block]], and [[Causes::hypotension]]		*Cardiovascular symptoms develop within a few hours, and include [[Causes::bradycardia]], [[Causes::heart block]], and [[Causes::hypotension]]
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	**Can last for weeks to months in a minority of cases		**Can last for weeks to months in a minority of cases

	== Investigations ==		==Investigations==

	* Mouse bioassay is the gold standard but not often done		*Mouse bioassay is the gold standard but not often done

	== Management ==		==Management==

	*Management is supportive		*Management is supportive

Aidan at 12:22, 24 August 2020

2020-08-24T12:22:02Z

← Older revision		Revision as of 12:22, 24 August 2020
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			== Background ==
⚫	* ~~Caused~~ by eating reef fish that have concentrated ciguatoxin

	** Barracuda and moray eel are classic
		⚫	*Foodborne illness caused by eating reef fish that have concentrated ciguatoxin
	* Causes GI symptoms (nausea, vomiting, and diarrhea), quickly followed by unusual neurological signs and symptoms (hot-cold reversal, cold allodynia, paresthesias)
			*Barracuda and moray eel are classic, but also amberjack, grouper, snapper, and parrotfish, and, rarely, farm-raised salmon
	* Can cause bradycardia, heart block, and hypotension

⚫	* Management is supportive
			=== Pathophysiology ===

			* [[Gambierdiscus species]] dinoflagellates that live on or around coral make ciguatera toxin, which concentrates in the fish
			* Toxin is heat-stable, acid-stable, and lipid-soluble

			== Clinical Manifestations ==

			*Incubation period of [[Usual incubation period::3 to 6 hours]] (range [[Incubation period range::up to 30 hours]])
			*Can present with a variety of symptoms, including gastrointestinal, neurologic, and cardiovascular
			*GI symptoms develop within 3 to 6 hours, and include [[Causes::nausea]], [[Causes::vomiting]], [[Causes:diarrhea]], and [[Causes::abdominal pain]]
			**Can take up to 4 days to resolve
			*Cardiovascular symptoms develop within a few hours, and include [[Causes::bradycardia]], [[Causes::heart block]], and [[Causes::hypotension]]
			**Can take up to 4 days to resolve
			*Neurological symptoms develop within 3 to 72 hours of ingestion, and include [[Causes::hot-cold reversal]], [[Causes::cold allodynia]], and [[Causes::paresthesias]]
			**Can last for weeks to months in a minority of cases

			== Investigations ==

			* Mouse bioassay is the gold standard but not often done

			== Management ==

		⚫	*Management is supportive
			*[[Mannitol]], [[gabapentin]], [[amitriptyline]], and [[pregabalin]] are sometimes used for the neurological symptoms

	[[Category:Travel medicine]]		[[Category:Travel medicine]]

Aidan: Initial page creation

2019-08-30T02:33:41Z

Initial page creation

New page

* Caused by eating reef fish that have concentrated ciguatoxin
** Barracuda and moray eel are classic
* Causes GI symptoms (nausea, vomiting, and diarrhea), quickly followed by unusual neurological signs and symptoms (hot-cold reversal, cold allodynia, paresthesias)
* Can cause bradycardia, heart block, and hypotension
* Management is supportive

[[Category:Travel medicine]]