Cidofovir - Revision history

Aidan: /* Safety */

2020-09-14T23:14:08Z

Safety

← Older revision		Revision as of 23:14, 14 September 2020
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	==Safety==		==Safety==

	*Major adverse effect is irreversible [[Adverse drug reaction::renal tubular necrosis]], which may be prevented by [[probenecid]]		*Major adverse effect is dose-dependent, irreversible [[Adverse drug reaction::renal tubular necrosis]], which may be prevented by [[probenecid]]
	*Contraindicated when creatinine >132 μmol/L, CrCl <55 mL/min, or urine protein ≥100 mg/dL (2+ proteinuria)		**Contraindicated when creatinine >132 μmol/L, CrCl <55 mL/min, or urine protein ≥100 mg/dL (2+ proteinuria)
			*[[Neutropenia]]
			*Acute [[iritis]]

	[[Category:Acyclic nucleoside phosphonates]]		[[Category:Acyclic nucleoside phosphonates]]

Aidan: /* Safety */

2020-09-14T23:12:25Z

Safety

← Older revision		Revision as of 23:12, 14 September 2020
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	==Safety==		==Safety==

	*Major adverse effect is ~~irriversible~~ [[Adverse drug reaction::renal tubular necrosis]], which may be prevented by [[probenecid]]		*Major adverse effect is irreversible [[Adverse drug reaction::renal tubular necrosis]], which may be prevented by [[probenecid]]
	*Contraindicated when creatinine >132 μmol/L, CrCl <55 mL/min, or urine protein ≥100 mg/dL (2+ proteinuria)		*Contraindicated when creatinine >132 μmol/L, CrCl <55 mL/min, or urine protein ≥100 mg/dL (2+ proteinuria)

Aidan: /* Safety */

2020-09-14T23:11:56Z

Safety

← Older revision		Revision as of 23:11, 14 September 2020
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	==Safety==		==Safety==

	*Major adverse effect is [[Adverse drug reaction::~~irreversible~~ renal tubular necrosis]], which may be prevented by [[probenecid]]		*Major adverse effect is irriversible [[Adverse drug reaction::renal tubular necrosis]], which may be prevented by [[probenecid]]
	*Contraindicated when creatinine >132 μmol/L, CrCl <55 mL/min, or urine protein ≥100 mg/dL (2+ proteinuria)		*Contraindicated when creatinine >132 μmol/L, CrCl <55 mL/min, or urine protein ≥100 mg/dL (2+ proteinuria)

Aidan at 01:22, 12 September 2020

2020-09-12T01:22:34Z

← Older revision		Revision as of 01:22, 12 September 2020
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	*Unlike [[ganciclovir]], it does ''not'' need phosphorylation by UL97		*Unlike [[ganciclovir]], it does ''not'' need phosphorylation by UL97
			*Does not penetrate CSF

	==Dosing==		==Dosing==
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	*Major adverse effect is [[Adverse drug reaction::irreversible renal tubular necrosis]], which may be prevented by [[probenecid]]		*Major adverse effect is [[Adverse drug reaction::irreversible renal tubular necrosis]], which may be prevented by [[probenecid]]
			*Contraindicated when creatinine >132 μmol/L, CrCl <55 mL/min, or urine protein ≥100 mg/dL (2+ proteinuria)

	[[Category:Acyclic nucleoside phosphonates]]		[[Category:Acyclic nucleoside phosphonates]]

Aidan: /* Background */

2020-09-11T17:55:46Z

Background

← Older revision		Revision as of 17:55, 11 September 2020
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	==Background==		==Background==

			*Acyclic nucleoside phosphonate that competes with cytosine nucleotides to inhibit viral DNA polymerase
	*Cytosine nucleotide analogue that inhibits DNA polymerase in [[human herpesviruses]]
	*Indications: {{#ask: [[Is treated by::cidofovir]] \| default=none}}		*Indications: {{#ask: [[Is treated by::cidofovir]] \| default=none}}

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	*Major adverse effect is [[Adverse drug reaction::irreversible renal tubular necrosis]], which may be prevented by [[probenecid]]		*Major adverse effect is [[Adverse drug reaction::irreversible renal tubular necrosis]], which may be prevented by [[probenecid]]

	[[Category:~~Antivirals~~]]		[[Category:Acyclic nucleoside phosphonates]]

Aidan: /* Spectrum of Activity */

2020-09-11T17:54:17Z

Spectrum of Activity

← Older revision		Revision as of 17:54, 11 September 2020
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	== Background ==		==Background==

	*Cytosine nucleotide analogue that inhibits DNA polymerase in [[human herpesviruses]]		*Cytosine nucleotide analogue that inhibits DNA polymerase in [[human herpesviruses]]
	*Indications: {{#ask: [[Is treated by::cidofovir]] \| default=none}}		*Indications: {{#ask: [[Is treated by::cidofovir]] \| default=none}}

	=== Spectrum of Activity ===		===Spectrum of Activity===

	* Active against essentially all DNA viruses, including polyomaviruses ([[BK virus]], [[JC virus]]), [[human papillomavirus]], [[adenovirus]], all of the [[human herpesviruses]], poxviruses (including [[monkeypox virus]] and [[variola virus]])		*Active against essentially all [[:Category:DNA viruses\|DNA viruses]], including polyomaviruses ([[BK virus]], [[JC virus]]), [[human papillomavirus]], [[adenovirus]], all of the [[human herpesviruses]], poxviruses (including [[monkeypox virus]] and [[variola virus]])
	* Not active against h[[Hepatitis B virus\|epatitis B virus]] or [[:Category:RNA viruses\|RNA viruses]]		*Not active against h[[Hepatitis B virus\|epatitis B virus]] or [[:Category:RNA viruses\|RNA viruses]]

	=== Pharmacokinetics and Pharmacodynamics ===		===Pharmacokinetics and Pharmacodynamics===

	* Unlike [[ganciclovir]], it does ''not'' need phosphorylation by UL97		*Unlike [[ganciclovir]], it does ''not'' need phosphorylation by UL97

	== Dosing ==		==Dosing==

	*Should be given with [[probenecid]] 2 g IV prior to each dose		*Should be given with [[probenecid]] 2 g IV prior to each dose

	== Safety ==		==Safety==

	*Major adverse effect is [[Adverse drug reaction::irreversible renal tubular necrosis]], which may be prevented by [[probenecid]]		*Major adverse effect is [[Adverse drug reaction::irreversible renal tubular necrosis]], which may be prevented by [[probenecid]]

Aidan at 17:54, 11 September 2020

2020-09-11T17:54:02Z

← Older revision		Revision as of 17:54, 11 September 2020
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			== Background ==
⚫	* Cytosine nucleotide analogue that inhibits DNA polymerase in [[human herpesviruses]]

⚫	* Should be given with [[probenecid]] 2 g IV prior to each dose
		⚫	*Cytosine nucleotide analogue that inhibits DNA polymerase in [[human herpesviruses]]
		⚫	*Indications: {{#ask: [[Is treated by::cidofovir]] \| default=none}}

			=== Spectrum of Activity ===

			* Active against essentially all DNA viruses, including polyomaviruses ([[BK virus]], [[JC virus]]), [[human papillomavirus]], [[adenovirus]], all of the [[human herpesviruses]], poxviruses (including [[monkeypox virus]] and [[variola virus]])
			* Not active against h[[Hepatitis B virus\|epatitis B virus]] or [[:Category:RNA viruses\|RNA viruses]]

			=== Pharmacokinetics and Pharmacodynamics ===

	* Unlike [[ganciclovir]], it does ''not'' need phosphorylation by UL97		* Unlike [[ganciclovir]], it does ''not'' need phosphorylation by UL97

⚫	* Indications: {{#ask: [[Is treated by::cidofovir]] \| default=none}}
			== Dosing ==
⚫	* Major adverse effect is [[Adverse drug reaction::irreversible renal tubular necrosis]], which may be prevented by probenecid

		⚫	*Should be given with [[probenecid]] 2 g IV prior to each dose

			== Safety ==

		⚫	*Major adverse effect is [[Adverse drug reaction::irreversible renal tubular necrosis]], which may be prevented by [[probenecid]]

	[[Category:Antivirals]]		[[Category:Antivirals]]

Aidan at 03:19, 18 February 2020

2020-02-18T03:19:09Z

← Older revision		Revision as of 03:19, 18 February 2020
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	* Unlike [[ganciclovir]], it does ''not'' need phosphorylation by UL97		* Unlike [[ganciclovir]], it does ''not'' need phosphorylation by UL97
	* Indications: {{#ask: [[Is treated by::cidofovir]] \| default=none}}		* Indications: {{#ask: [[Is treated by::cidofovir]] \| default=none}}
	* Major adverse effect is irreversible renal tubular necrosis, which may be prevented by probenecid		* Major adverse effect is [[Adverse drug reaction::irreversible renal tubular necrosis]], which may be prevented by probenecid

	[[Category:Antivirals]]		[[Category:Antivirals]]

Aidan at 02:03, 24 October 2019

2019-10-24T02:03:55Z

← Older revision		Revision as of 02:03, 24 October 2019
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	* Cytosine nucleotide analogue that inhibits DNA polymerase in [[human herpesviruses]]		* Cytosine nucleotide analogue that inhibits DNA polymerase in [[human herpesviruses]]
			* Should be given with [[probenecid]] 2 g IV prior to each dose
	* Unlike [[ganciclovir]], it does ''not'' need phosphorylation by UL97		* Unlike [[ganciclovir]], it does ''not'' need phosphorylation by UL97
	* Indications: {{#ask: [[Is treated by::cidofovir]] \| default=none}}		* Indications: {{#ask: [[Is treated by::cidofovir]] \| default=none}}
			* Major adverse effect is irreversible renal tubular necrosis, which may be prevented by probenecid

	[[Category:Antivirals]]		[[Category:Antivirals]]

Aidan: Created page with "* Cytosine nucleotide analogue that inhibits DNA polymerase in human herpesviruses * Unlike ganciclovir, it does ''not'' need phosphorylation by UL97 * Indications: {{..."

2019-10-24T02:02:03Z

Created page with "* Cytosine nucleotide analogue that inhibits DNA polymerase in human herpesviruses * Unlike ganciclovir, it does ''not'' need phosphorylation by UL97 * Indications: {{..."

New page

* Cytosine nucleotide analogue that inhibits DNA polymerase in [[human herpesviruses]]
* Unlike [[ganciclovir]], it does ''not'' need phosphorylation by UL97
* Indications: {{#ask: [[Is treated by::cidofovir]] | default=none}}

[[Category:Antivirals]]