Chronic myeloid leukemia - Revision history

Aidan at 14:34, 20 February 2022

2022-02-20T14:34:55Z

← Older revision		Revision as of 14:34, 20 February 2022
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	*Triphasic: chronic phase, accelerated phase, and blast crisis		*Triphasic: chronic phase, accelerated phase, and blast crisis
	*Almost half are asymptomatic on diagnosis		*Almost half are asymptomatic on diagnosis, found by abnormalities on routine bloodwork
	*Presenting complaints may include fatigue, weight loss, sweating, abdominal fullness, and bleeding		*Presenting complaints may include fatigue, weight loss, sweating, abdominal fullness, and bleeding
	*Often have [[splenomegaly]], which can contribute to the abdominal fullness and cause LUQ or left shoulder pain		*Often have [[splenomegaly]], which can contribute to the abdominal fullness and cause LUQ or left shoulder pain
	*Can present with anemia, very elevated WBCs, and elevated platelets		*Can present with anemia, very elevated WBCs, and elevated platelets
			*Can precipitate [[gout]]
			*Extramedullary findings are usually limited to blast crisis, and would include lymphadenopathy, skin findings, and soft tissue findings

	===Prognosis and Complications===		===Prognosis and Complications===

Aidan at 21:03, 26 February 2021

2021-02-26T21:03:02Z

← Older revision		Revision as of 21:03, 26 February 2021
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	*Can present with anemia, very elevated WBCs, and elevated platelets		*Can present with anemia, very elevated WBCs, and elevated platelets

	=== Prognosis and Complications ===		===Prognosis and Complications===

	* Outcomes are very good since the introduction of tyrosine kinase inhibitors		*Outcomes are very good since the introduction of tyrosine kinase inhibitors
	* Prognostic models exist, including Sokal, Euro (Hasford), EUTOS, and ELTS scores		*Prognostic models exist, including [[Sokal score]], Euro (Hasford), EUTOS, and ELTS scores

	== Differential Diagnosis ==		==Differential Diagnosis==

	* [[Leukemoid reaction]]		*[[Leukemoid reaction]]
	* [[Juvenile myelomonocytic leukemia]]		*[[Juvenile myelomonocytic leukemia]]
	* [[Chronic myelomonocytic leukemia]]		*[[Chronic myelomonocytic leukemia]]
	* [[Chronic eosinophilic leukemia]]		*[[Chronic eosinophilic leukemia]]
	* [[Chronic neutrophilic leukemia]]		*[[Chronic neutrophilic leukemia]]

	== Diagnosis ==		==Diagnosis==

	* Usually suspected in asymptomatic patient with typical findings in peripheral blood or bone marrow		*Usually suspected in asymptomatic patient with typical findings in peripheral blood or bone marrow
	* Confirmed with detection of BCR-ABL1 fusion gene in peripheral blood or bone marrow		*Confirmed with detection of BCR-ABL1 fusion gene in peripheral blood or bone marrow

	== Management ==		==Management==

	* Can use empiric [[hydroxyurea]] for cytoreduction while awaiting diagnosis if WBC >80		*Can use empiric [[hydroxyurea]] for cytoreduction while awaiting diagnosis if WBC >80

	[[Category:Hematology]]		[[Category:Hematology]]

Aidan at 21:02, 26 February 2021

2021-02-26T21:02:13Z

@@ Line 1: / Line 1: @@
-== Clinical Manifestations ==
+==Clinical Manifestations==
-* Triphasic: chronic phase, accelerated phase, and blast crisis
+*Triphasic: chronic phase, accelerated phase, and blast crisis
-* Almost half are asymptomatic on diagnosis
+*Almost half are asymptomatic on diagnosis
-* Prsenting complaints may include fatigue, weight loss, sweating, abdominal fullness, and bleeding
+*Presenting complaints may include fatigue, weight loss, sweating, abdominal fullness, and bleeding
-* Often have splenomegaly, which can contribute to the abdominal fullness and cause LUQ or left shoulder pain
+*Often have [[splenomegaly]], which can contribute to the abdominal fullness and cause LUQ or left shoulder pain
-* Can present with anemia, very elevated WBCs, and elevated platelets
+*Can present with anemia, very elevated WBCs, and elevated platelets
 [[Category:Hematology]]

Aidan: Text replacement - "Clinical Presentation" to "Clinical Manifestations"

2020-07-16T14:19:19Z

Text replacement - "Clinical Presentation" to "Clinical Manifestations"

← Older revision		Revision as of 14:19, 16 July 2020
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	== Clinical ~~Presentation~~ ==		== Clinical Manifestations ==

	* Triphasic: chronic phase, accelerated phase, and blast crisis		* Triphasic: chronic phase, accelerated phase, and blast crisis

Maintenance script: Imported from text file

2020-07-04T01:17:28Z

Imported from text file

New page

== Clinical Presentation ==

* Triphasic: chronic phase, accelerated phase, and blast crisis
* Almost half are asymptomatic on diagnosis
* Prsenting complaints may include fatigue, weight loss, sweating, abdominal fullness, and bleeding
* Often have splenomegaly, which can contribute to the abdominal fullness and cause LUQ or left shoulder pain
* Can present with anemia, very elevated WBCs, and elevated platelets

[[Category:Hematology]]
[[Category:Oncology]]