Chorioamnionitis - Revision history

Aidan at 14:56, 3 March 2023

2023-03-03T14:56:06Z

← Older revision		Revision as of 14:56, 3 March 2023
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	== Background ==		== Background ==

	* Ascending bacterial infection leading to inflammation of the ~~membranes~~ and ~~placenta~~		* Ascending bacterial infection leading to inflammation of the amniotic cavity and chorioamnionic memranes
	* Also called intraamniotic infection		* Also called intraamniotic infection, amnionitis, amnionic fluid infection

	=== Microbiology ===		=== Microbiology ===

	* Usually '''polymicrobial'''		* Usually '''polymicrobial'''
			* Non-stainable:
	* [[Ureaplasma urealyticum]] (47%)
	* [[~~Mycoplasma~~ ~~hominis~~]] (30%)		** [[Ureaplasma urealyticum]] (47%)
	* [[~~Gardnerella~~ ~~vaginalis~~]] (25%)		** [[Mycoplasma hominis]] (30%)
			* Gram-positives:
⚫	* [[Bacteroides]] (30%)
	* [[Group B streptococcus]] (15%)		** [[Group B streptococcus]] (15%)
	* [[~~Escherichia~~ ~~coli~~]] ~~(8%)~~		** [[Enterococcus faecalis]]
			** [[Staphylococcus aureus]]
			** Other [[streptococci]]
			* Gram-negatives:
			** [[Escherichia coli]] (8%)
			** Other [[gram-negative bacilli]]
			* Anaerobes:
		⚫	** [[Bacteroides]] (30%)
			** [[Gardnerella vaginalis]] (25%)
			** [[Fusobacterium]]
			** [[Peptostreptococcus]], [[Peptococcus]], [[Clostridium]]

	=== Epidemiology ===		=== Epidemiology ===

Aidan: Text replacement - " species]]" to "]]"

2022-02-08T02:47:34Z

Text replacement - " species]]" to "]]"

← Older revision		Revision as of 02:47, 8 February 2022
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	* [[Mycoplasma hominis]] (30%)		* [[Mycoplasma hominis]] (30%)
	* [[Gardnerella vaginalis]] (25%)		* [[Gardnerella vaginalis]] (25%)
	* [[Bacteroides ~~species~~]] (30%)		* [[Bacteroides]] (30%)
	* [[Group B streptococcus]] (15%)		* [[Group B streptococcus]] (15%)
	* [[Escherichia coli]] (8%)		* [[Escherichia coli]] (8%)

Aidan: added a citation

2021-12-10T13:54:23Z

added a citation

← Older revision		Revision as of 13:54, 10 December 2021
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	== Management ==		== Management ==

	* Typically treated with [[ampicillin]] q6h and [[gentamicin]] q8-24h until delivery, with or without [[clindamycin]] or [[metronidazole]]		* Typically treated with [[ampicillin]] q6h and [[gentamicin]] q8-24h until delivery, with or without [[clindamycin]] or [[metronidazole]][[CiteRef::tita2010di]]
	* Duration is until delivery followed by one further dose of antibiotics		* Duration is until delivery followed by one further dose of antibiotics

	== Prevention ==		== Prevention ==

	* In patients with [[preterm premature rupture of membranes]] (PPROM), the risk of chorioamnionitis is high and they should receive prophylactic [[ampicillin]] and [[erythromycin]] (or [[azithromycin]]) (per ORACLE I and II trials)		* In patients with [[preterm premature rupture of membranes]] (PPROM), the risk of chorioamnionitis is high and they should receive prophylactic [[ampicillin]] and [[erythromycin]] (or [[azithromycin]]) (per ORACLE I and II trials)[[CiteRef::tita2010di]]
	** Often given IV for 2 days followed by oral for a total of 7 to 10 days		** Often given IV for 2 days followed by oral for a total of 7 to 10 days

Aidan at 13:53, 10 December 2021

2021-12-10T13:53:23Z

← Older revision		Revision as of 13:53, 10 December 2021
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	* Typically treated with [[ampicillin]] q6h and [[gentamicin]] q8-24h until delivery, with or without [[clindamycin]] or [[metronidazole]]		* Typically treated with [[ampicillin]] q6h and [[gentamicin]] q8-24h until delivery, with or without [[clindamycin]] or [[metronidazole]]
	* Duration is until delivery followed by one further dose of antibiotics		* Duration is until delivery followed by one further dose of antibiotics

			== Prevention ==

			* In patients with [[preterm premature rupture of membranes]] (PPROM), the risk of chorioamnionitis is high and they should receive prophylactic [[ampicillin]] and [[erythromycin]] (or [[azithromycin]]) (per ORACLE I and II trials)
			** Often given IV for 2 days followed by oral for a total of 7 to 10 days

	[[Category:Obstetrical infections]]		[[Category:Obstetrical infections]]

Aidan at 13:50, 10 December 2021

2021-12-10T13:50:19Z

← Older revision		Revision as of 13:50, 10 December 2021
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	* May have purulent or malodorous amniotic fluid		* May have purulent or malodorous amniotic fluid
	* Can be complicated by [[endometritis]], [[pelvic abscess]], surgical site infection, [[bacteremia]], [[postpartum hemorrhage]], and poor neonatal outcomes		* Can be complicated by [[endometritis]], [[pelvic abscess]], surgical site infection, [[bacteremia]], [[postpartum hemorrhage]], and poor neonatal outcomes

			== Management ==

			* Typically treated with [[ampicillin]] q6h and [[gentamicin]] q8-24h until delivery, with or without [[clindamycin]] or [[metronidazole]]
			* Duration is until delivery followed by one further dose of antibiotics

	[[Category:Obstetrical infections]]		[[Category:Obstetrical infections]]

Aidan: added risk factors

2021-12-10T13:38:42Z

added risk factors

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 * 1 to 4% of all birth
 * More common with preterm delivery, PROM, prolonged labour, smoking/alcohol/drug use, multiple vaginal examination, internal monitoring of labour, bacterial vaginosis, colonization by group B streptococcus, and nulliparity
 == Clinical Manifestations ==

Aidan: Created page with "== Background == * Ascending bacterial infection leading to inflammation of the membranes and placenta * Also called intraamniotic infection === Microbiology === * Usually..."

2020-08-24T14:41:01Z

Created page with "== Background == * Ascending bacterial infection leading to inflammation of the membranes and placenta * Also called intraamniotic infection === Microbiology === * Usually..."

New page

== Background ==

* Ascending bacterial infection leading to inflammation of the membranes and placenta
* Also called intraamniotic infection

=== Microbiology ===

* Usually '''polymicrobial'''
* [[Ureaplasma urealyticum]] (47%)
* [[Mycoplasma hominis]] (30%)
* [[Gardnerella vaginalis]] (25%)
* [[Bacteroides species]] (30%)
* [[Group B streptococcus]] (15%)
* [[Escherichia coli]] (8%)

=== Epidemiology ===

* 1 to 4% of all birth
* More common with preterm delivery, PROM, prolonged labour, smoking/alcohol/drug use, multiple vaginal examination, internal monitoring of labour, bacterial vaginosis, colonization by group B streptococcus, and nulliparity

== Clinical Manifestations ==

* [[Causes::Fever]], tenderness over the uterine fundus, maternal tachycardia, fetal tachycardia
* May have purulent or malodorous amniotic fluid
* Can be complicated by [[endometritis]], [[pelvic abscess]], surgical site infection, [[bacteremia]], [[postpartum hemorrhage]], and poor neonatal outcomes

[[Category:Obstetrical infections]]