Chikungunya virus - Revision history

Aidan: /* Clinical Manifestations */

2020-08-22T18:13:06Z

Clinical Manifestations

← Older revision		Revision as of 18:13, 22 August 2020
Line 16:		Line 16:
	*Incubation period of [[Usual incubation period::1 to 12 days]]		*Incubation period of [[Usual incubation period::1 to 12 days]]
	*[[Causes::Fever]], [[Causes::rash]], and [[Causes::arthralgias]]		*[[Causes::Fever]], [[Causes::rash]], and [[Causes::arthralgias]]
	*Fever may be "saddleback", with remittance at 4 to 8 days followed by recrudescence for 2 weeks		**Fever may be "saddleback", with remittance at 4 to 8 days followed by recrudescence for 2 weeks
	*Arthritis is typically a symmetrical polyarticular arthritis that involves small joints and knees		**Arthritis is typically a symmetrical polyarticular arthritis that involves small joints and knees
	**Resolves over months to a year (sometimes longer), but arthralgias (± arthritis) can persist for years		***Resolves over months to a year (sometimes longer), but arthralgias (± arthritis) can persist for years
	*Rash is macular or maculopapular, and more often central but can involve palms and soles		**Rash is macular or maculopapular, and more often central but can involve palms and soles
	*Other common symptoms include headache, fatigue, nausea, vomiting, and conjunctivitis		*Other common symptoms include headache, fatigue, nausea, vomiting, and conjunctivitis
	*Bloodwork shows leukopenia, thrombocytopenia, hypocalcemia, and mild to moderate transaminase elevation		*Bloodwork shows leukopenia, thrombocytopenia, hypocalcemia, and mild to moderate transaminase elevation
	*Children are more likely to develop neurological symptoms (status epilepticus, complex seizures, and encephalitis) and dermatologic symptoms (bullous rash)		*Children are more likely to develop neurological symptoms (status epilepticus, complex seizures, and encephalitis) and dermatologic symptoms (bullous rash)

	== Differential Diagnosis ==		==Differential Diagnosis==
	{\| class="wikitable"		{\| class="wikitable"
	!Feature		!Feature

Aidan: /* Clinical Manifestations */

2020-08-22T18:12:43Z

Clinical Manifestations

← Older revision		Revision as of 18:12, 22 August 2020
Line 24:		Line 24:
	*Children are more likely to develop neurological symptoms (status epilepticus, complex seizures, and encephalitis) and dermatologic symptoms (bullous rash)		*Children are more likely to develop neurological symptoms (status epilepticus, complex seizures, and encephalitis) and dermatologic symptoms (bullous rash)

			== Differential Diagnosis ==
			{\| class="wikitable"
			!Feature
			![[Dengue]]
			![[Zika]]
			!Chikungunya
			\|-
			\|Asymptomatic
			\|40-80%
			\|35-85%
			\|3-28%
			\|-
			\|Fever
			\| +++
			\| ++
			\| +++
			\|-
			\|Rash
			\| +
			\| +++
			\| ++
			\|-
			\|Conjunctivitis
			\|–
			\| ++
			\| +
			\|-
			\|Arthralgia
			\| +
			\| ++
			\| +++
			\|-
			\|Myalgia
			\| ++
			\| +
			\| +
			\|-
			\|Headache
			\| ++
			\| +
			\| ++
			\|-
			\|Hemorrhage
			\| ++
			\|–
			\|–
			\|-
			\|Shock
			\| +
			\|–
			\|–
			\|-
			\|Thrombocytopenia
			\| +++
			\| +
			\|–
			\|-
			\|Leukopenia
			\| ++
			\|–
			\| ++
			\|}
	==Management==		==Management==

Aidan: /* Management */

2020-08-05T13:48:09Z

Management

@@ Line 1: / Line 1: @@
-== Background ==
+==Background==
-=== Microbiology ===
+===Microbiology===
 [[Category:Togaviridae]]

Aidan: /* Clinical Manifestations */

2020-08-05T13:47:56Z

Clinical Manifestations

← Older revision		Revision as of 13:47, 5 August 2020
Line 11:		Line 11:

	== Clinical Manifestations ==		== Clinical Manifestations ==
	* Incubation period of 1 to 12 days		* Incubation period of [[Usual incubation period::1 to 12 days]]
	* Fever, rash, and arthralgias		* [[Causes::Fever]], [[Causes::rash]], and [[Causes::arthralgias]]
	* Fever may be "saddleback", with remittance at 4 to 8 days followed by recrudescence for 2 weeks		* Fever may be "saddleback", with remittance at 4 to 8 days followed by recrudescence for 2 weeks
	* Arthritis is typically a symmetrical polyarticular arthritis that involves small joints and knees		* Arthritis is typically a symmetrical polyarticular arthritis that involves small joints and knees

Aidan: Text replacement - "Clinical Presentation" to "Clinical Manifestations"

2020-07-20T12:45:02Z

Text replacement - "Clinical Presentation" to "Clinical Manifestations"

← Older revision		Revision as of 12:45, 20 July 2020
Line 10:		Line 10:
	** There has been autochthonous transmission in Italy and Frace		** There has been autochthonous transmission in Italy and Frace

	== Clinical ~~Presentation~~ ==		== Clinical Manifestations ==
	* Incubation period of 1 to 12 days		* Incubation period of 1 to 12 days
	* Fever, rash, and arthralgias		* Fever, rash, and arthralgias

Aidan: /* Microbiology */ typo

2020-03-08T02:59:12Z

Microbiology: typo

← Older revision		Revision as of 02:59, 8 March 2020
Line 2:		Line 2:
	=== Microbiology ===		=== Microbiology ===
	* Member of the ''Alphavirus'' genus within the ''Togaviridae'' family		* Member of the ''Alphavirus'' genus within the ''Togaviridae'' family
	** Closely related to [[~~O’nyong~~-~~Nyong~~ virus]]		** Closely related to [[o’nyong-nyong virus]]
	* Four genotypes: East-Central-South African, West African, Indian Ocean, and Asian		* Four genotypes: East-Central-South African, West African, Indian Ocean, and Asian

Aidan: significant expansion

2020-03-08T02:58:53Z

significant expansion

@@ Line 1: / Line 1: @@
-== Presentation ==
+== Background ==
 == Management ==
 * High-dose NSAIDs
-* May need aggressive rheumatology medications for arthritis
+* May need aggressive rheumatologic medications for arthritis
 * Supportive treatment
 == Prognosis ==
 * 12% risk of chronic arthralgias up to 3 years post-infection
 * Neonates and elderly at highest risk for neurological sequelae

Aidan at 15:05, 17 August 2019

2019-08-17T15:05:07Z

← Older revision		Revision as of 15:05, 17 August 2019
Line 1:		Line 1:
	= ~~Chikungunya~~ =		== Presentation ==

	= Definition =

	* Infection with the Chikungunya virus

	= Presentation =

	* History		* History
Line 12:		Line 6:
	** Arthralgias		** Arthralgias

	= Management =		== Management ==

	* High-dose NSAIDs		* High-dose NSAIDs
Line 18:		Line 12:
	* Supportive treatment		* Supportive treatment

	= Prognosis =		== Prognosis ==

	* 12% risk of chronic arthralgias up to 3 years post-infection		* 12% risk of chronic arthralgias up to 3 years post-infection

Aidan at 23:34, 14 August 2019

2019-08-14T23:34:34Z

← Older revision		Revision as of 23:34, 14 August 2019
Line 1:		Line 1:
	= Chikungunya =		= Chikungunya =

	== Definition ==		= Definition =

	* Infection with the Chikungunya virus		* Infection with the Chikungunya virus

	== Presentation ==		= Presentation =

	* History		* History
Line 12:		Line 12:
	** Arthralgias		** Arthralgias

	== Management ==		= Management =

	* High-dose NSAIDs		* High-dose NSAIDs
Line 18:		Line 18:
	* Supportive treatment		* Supportive treatment

	== Prognosis ==		= Prognosis =

	* 12% risk of chronic arthralgias up to 3 years post-infection		* 12% risk of chronic arthralgias up to 3 years post-infection
	* Neonates and elderly at highest risk for neurological sequelae		* Neonates and elderly at highest risk for neurological sequelae

			[[Category:Togaviridae]]

Aidan: Aidan moved page RNA to Chikungunya virus without leaving a redirect

2019-08-14T23:33:48Z

Aidan moved page RNA to Chikungunya virus without leaving a redirect

← Older revision	Revision as of 23:33, 14 August 2019
(No difference)