Ceftazidime-avibactam - Revision history

Aidan at 19:05, 24 November 2021

2021-11-24T19:05:57Z

← Older revision		Revision as of 19:05, 24 November 2021
Line 28:		Line 28:
	==Dosing==		==Dosing==

	*Ceftazidime-avibactam 2.5 g (2 g / 0.5 g) IV q8h, infused over 2 hours		*Ceftazidime-avibactam 2.5 g (2 g / 0.5 g) IV q8h, infused over 3 hours
			**Consider adjunctive [[aztreonam]] 2 g IV q8h infused concurrently over 3 hours for metallo-β-lactamase-producing carbapenem-resistant [[Enterobacterales]] or [[Stenotrophomonas maltophilia]]

	===Pediatric Dosing===		===Pediatric Dosing===

Aidan: /* Mechanism of Action */

2020-10-17T16:21:15Z

Mechanism of Action

← Older revision		Revision as of 16:21, 17 October 2020
Line 9:		Line 9:
	**Inhibitis class A, C, and some class D beta-lactamases, includign OXA-48		**Inhibitis class A, C, and some class D beta-lactamases, includign OXA-48
	**No activity against class B		**No activity against class B
	**Reduces MIC to ceftazidime in most Enterobacterales including [[Pseudomonas]]		**Reduces MIC to ceftazidime in most [[Enterobacterales]] including [[Pseudomonas]]
	**Does not induce AmpC expression		**Does not induce AmpC expression
	**Slowly-reversible inhibitor that gets ~~recycld~~		**Slowly-reversible inhibitor that gets recycled

	===Spectrum of Activity===		===Spectrum of Activity===

	*GNBs		*GNBs
	**Active against carbapenem resistant [[Enterobaceriaceaea]], including KPCs and AmpC lactamases-		**Active against carbapenem-resistant [[Enterobaceriaceaea]], including KPCs and AmpC beta-lactamases
	**Restores activity with ~~cefatzidime~~ in [[Pseudomonas]] and other GNBs		**Restores activity with [[ceftazidime]] in [[Pseudomonas]] and other GNBs
	**Poor activity against [[Acinetobacter]] and [[Stenotrophomonas]]		**Poor activity against [[Acinetobacter]] and [[Stenotrophomonas]]

Line 26:		Line 26:
	*Primarily renally cleared		*Primarily renally cleared

	== Dosing ==		==Dosing==

	* Ceftazidime-avibactam 2.5 g (2 g / 0.5 g) IV q8h, infused over 2 hours		*Ceftazidime-avibactam 2.5 g (2 g / 0.5 g) IV q8h, infused over 2 hours

	=== Pediatric Dosing ===		===Pediatric Dosing===

	* 3 months to <6 months: ceftazidime 40 mg/kg plus avibactam 10 mg/kg IV q8h, infused over 2 hours		*3 months to <6 months: ceftazidime 40 mg/kg plus avibactam 10 mg/kg IV q8h, infused over 2 hours
	* 6 months to <18 years: ceftazidime 50 mg/kg plus avibactam 12.5 mg/kg IV q8h, infused over 2 hours		*6 months to <18 years: ceftazidime 50 mg/kg plus avibactam 12.5 mg/kg IV q8h, infused over 2 hours

Aidan at 13:37, 12 September 2020

2020-09-12T13:37:11Z

← Older revision		Revision as of 13:37, 12 September 2020
Line 1:		Line 1:
	== Background ==		==Background==

	* Brand name Avycaz		*Brand name Avycaz

	=== Mechanism of Action ===		===Mechanism of Action===

	* [[Ceftazidime]] is a third-generation cephalosporin		*[[Ceftazidime]] is a third-generation cephalosporin
	* [[Avibactam]]		*[[Avibactam]]
	** Inhibitis class A, C, and some class D beta-lactamases, includign OXA-48		**Inhibitis class A, C, and some class D beta-lactamases, includign OXA-48
	** No activity against class B		**No activity against class B
	** Reduces MIC to ceftazidime in most Enterobacterales including [[Pseudomonas]]		**Reduces MIC to ceftazidime in most Enterobacterales including [[Pseudomonas]]
	** Does not induce AmpC expression		**Does not induce AmpC expression
	** Slowly-reversible inhibitor that gets recycld		**Slowly-reversible inhibitor that gets recycld

	=== Spectrum of Activity ===		===Spectrum of Activity===

	* GNBs		*GNBs
	** Active against carbapenem resistant [[Enterobaceriaceaea]], including KPCs and AmpC lactamases-		**Active against carbapenem resistant [[Enterobaceriaceaea]], including KPCs and AmpC lactamases-
	** Restores activity with cefatzidime in [[Pseudomonas]] and other GNBs		**Restores activity with cefatzidime in [[Pseudomonas]] and other GNBs
	** Poor activity against [[Acinetobacter]] and [[Stenotrophomonas]]		**Poor activity against [[Acinetobacter]] and [[Stenotrophomonas]]

			===Pharmacokinetics and Pharmacodynamics===
⚫	=== ~~PK/PD~~ ===

	* Short half-life 2.7 hours		*Short half-life 2.7 hours
	* Low protein binding		*Low protein binding
	* Primarily renally cleared		*Primarily renally cleared

		⚫	== Dosing ==

			* Ceftazidime-avibactam 2.5 g (2 g / 0.5 g) IV q8h, infused over 2 hours

			=== Pediatric Dosing ===

			* 3 months to <6 months: ceftazidime 40 mg/kg plus avibactam 10 mg/kg IV q8h, infused over 2 hours
			* 6 months to <18 years: ceftazidime 50 mg/kg plus avibactam 12.5 mg/kg IV q8h, infused over 2 hours

Aidan: Created page with "== Background == * Brand name Avycaz === Mechanism of Action === * Ceftazidime is a third-generation cephalosporin * Avibactam ** Inhibitis class A, C, and some cla..."

2020-08-26T13:29:04Z

Created page with "== Background == * Brand name Avycaz === Mechanism of Action === * Ceftazidime is a third-generation cephalosporin * Avibactam ** Inhibitis class A, C, and some cla..."

New page

== Background ==

* Brand name Avycaz

=== Mechanism of Action ===

* [[Ceftazidime]] is a third-generation cephalosporin
* [[Avibactam]]
** Inhibitis class A, C, and some class D beta-lactamases, includign OXA-48
** No activity against class B
** Reduces MIC to ceftazidime in most Enterobacterales including [[Pseudomonas]]
** Does not induce AmpC expression
** Slowly-reversible inhibitor that gets recycld

=== Spectrum of Activity ===

* GNBs
** Active against carbapenem resistant [[Enterobaceriaceaea]], including KPCs and AmpC lactamases-
** Restores activity with cefatzidime in [[Pseudomonas]] and other GNBs
** Poor activity against [[Acinetobacter]] and [[Stenotrophomonas]]

=== PK/PD ===

* Short half-life 2.7 hours
* Low protein binding
* Primarily renally cleared