Caspofungin - Revision history

Aidan at 18:44, 5 February 2026

2026-02-05T18:44:49Z

← Older revision		Revision as of 18:44, 5 February 2026
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	* No specific recommendations		* No specific recommendations

			=== Obesity Dosing ===

			* 70 mg IV q24h

	== Safety ==		== Safety ==
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	=== Adverse Drug Events ===		=== Adverse Drug Events ===

			* Generally very safe with few adverse effects
⚫	* ~~Fevers~~, chills~~, phlebitis/thrombophlebitis, tachycardia~~, nausea, vomiting, rash, abdominal pain, headache, and diarrhea
			* Most common adverse effects are infusion reaction with rash, pruritus, warmth
⚫	* ~~Modest~~ liver enzyme elevations
		⚫	* Sometimes fevers, chills, nausea, vomiting, rash, abdominal pain, headache, and diarrhea
		⚫	* Occasional modest liver enzyme elevations
			* Reversible thrombocytopenia

	=== Monitoring ===		=== Monitoring ===

	* ~~Liver~~ enzymes		* Consider liver enzymes
	* No specific recommendations		* No specific recommendations

Aidan: /* Monitoring */

2025-12-29T14:54:42Z

Monitoring

← Older revision		Revision as of 14:54, 29 December 2025
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	* Liver enzymes		* Liver enzymes

	* No specific recommendations		* No specific recommendations

Aidan: Liver dosing

2023-04-01T15:48:35Z

Liver dosing

← Older revision		Revision as of 15:48, 1 April 2023
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	=== Hepatic Dosing ===		=== Hepatic Dosing ===

	* Reduce to 35 mg IV daily in cases of moderate hepatic impairment		* Reduce to 70 mg IV load followed by 35 mg IV daily in cases of moderate or severe hepatic impairment ([[Child-Pugh classification\|Child-Pugh class]] B or C)

	=== Renal Dosing ===		=== Renal Dosing ===

Aidan: Text replacement - " species]]" to "]]"

2022-02-11T13:46:31Z

Text replacement - " species]]" to "]]"

← Older revision		Revision as of 13:46, 11 February 2022
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	=== Spectrum of Activity ===		=== Spectrum of Activity ===

	* Active against [[Candida ~~species~~]], [[Aspergillus ~~species~~]]		* Active against [[Candida]], [[Aspergillus]]

	=== Pharmacokinetics and Pharmacodynamics ===		=== Pharmacokinetics and Pharmacodynamics ===

Aidan: Created page with "== Background == * Echinocandin antifungal === Mechanism of Action === * Like all echinocandins, inhibits β-D-glucan synthase === Spectrum of Activity === * Active again..."

2020-09-06T00:12:45Z

Created page with "== Background == * Echinocandin antifungal === Mechanism of Action === * Like all echinocandins, inhibits β-D-glucan synthase === Spectrum of Activity === * Active again..."

New page

== Background ==

* Echinocandin antifungal

=== Mechanism of Action ===

* Like all echinocandins, inhibits β-D-glucan synthase

=== Spectrum of Activity ===

* Active against [[Candida species]], [[Aspergillus species]]

=== Pharmacokinetics and Pharmacodynamics ===

* Only 2% excreted unchanged in the kidney

== Dosing ==

* Caspofungin 70 mg IV over 1 hour followed by 50 mg IV daily
* May be increased to 70 mg daily with cytochrome P450 3A4 inducers such as [[rifampin]], [[nevirapine]], [[efavirenz]], [[carbamazepine]], [[dexamethasone]], and [[phenytoin]]

=== Pediatric Dosing ===

* Casponfungin 70 mg/m<sup>2</sup> IV followed by 50 mg/m<sup>2</sup> IV daily

=== Hepatic Dosing ===

* Reduce to 35 mg IV daily in cases of moderate hepatic impairment

=== Renal Dosing ===

* No specific recommendations

== Safety ==

=== Adverse Drug Events ===

* Fevers, chills, phlebitis/thrombophlebitis, tachycardia, nausea, vomiting, rash, abdominal pain, headache, and diarrhea
* Modest liver enzyme elevations

=== Monitoring ===

* Liver enzymes

* No specific recommendations

[[Category:Echinocandins]]