Carbapenem-resistant organisms - Revision history

Aidan: colour coding

2024-11-14T02:43:00Z

colour coding

@@ Line 109: / Line 109: @@
 |-
 |[[polymixins]]
+|
 |-
 |[[aztreonam]]
+|
 |-
 |[[temocillin]]
+|
 |}

Aidan at 02:42, 14 November 2024

2024-11-14T02:42:10Z

@@ Line 5: / Line 5: @@
 ==Management==
-* See also [[Carbapenem-resistant Enterobacterales]]
+* See also [[Carbapenem-resistant Enterobacterales]] and ESCMID guidelines[[CiteRef::paul2022eu]]
 {| class="wikitable"
@@ Line 13: / Line 13: @@
 !OXA-48
 !CRPsA
 !Stenotrophomonas
 |-
 |[[aztreonam-avibactam]]
@@ Line 55: / Line 57: @@
 | style="color:darkgreen;text-align:center" | +
 | style="color:darkgreen;text-align:center" | +
 |-
 |[[imipenem-relebactam]]
@@ Line 84: / Line 78: @@
 | style="color:goldenrod;text-align:center" |±
 | style="color:darkgreen;text-align:center" | +
 | style="color:goldenrod;text-align:center" |±
 | style="color:darkred;text-align:center" |–
@@ Line 103: / Line 107: @@
 | style="color:darkgreen;text-align:center" | +
 | style="color:darkgreen;text-align:center" | +
 |}

Aidan at 02:29, 14 November 2024

2024-11-14T02:29:24Z

← Older revision		Revision as of 02:29, 14 November 2024
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	*For metallo-β-lactamases, consider: [[aztreonam-avibactam]], or [[ceftazidime-avibactam]] plus [[aztreonam]], [[cefiderocol]]		*For metallo-β-lactamases, consider: [[aztreonam-avibactam]], or [[ceftazidime-avibactam]] plus [[aztreonam]], [[cefiderocol]]
	*For all of the above, also consider: [[eravacycline]], [[tigecycline]], [[colistin]] (though increasing resistance), [[plazomicin]]		*For all of the above, also consider: [[eravacycline]], [[tigecycline]], [[colistin]] (though increasing resistance), [[plazomicin]]
	*For carbapenem-resistant [[Pseudomonas aeruginosa]], consider: [[cefiderocol]], [[imipenem-relebactam]]		*For carbapenem-resistant [[Pseudomonas aeruginosa]], consider: [[ceftolozane-tazobactam]] (if susceptible), [[cefiderocol]], [[imipenem-relebactam]]

	=== Dosing ===		=== Dosing ===

Aidan: /* Management */

2024-11-14T02:23:31Z

Management

← Older revision		Revision as of 02:23, 14 November 2024
Line 4:		Line 4:

	==Management==		==Management==

			* See also [[Carbapenem-resistant Enterobacterales]]

	{\| class="wikitable"		{\| class="wikitable"
	!Antibiotic		!Antibiotic

Aidan at 12:58, 30 August 2022

2022-08-30T12:58:19Z

@@ Line 102: / Line 102: @@
 |}
-*For KPC, the most common Class A carbapenemase, consider:
+*For KPC (the most common Class A carbapenemase) consider: [[ceftazidime-avibactam]], [[meropenem-vaborbactam]], [[imipenem-relebactam]], [[cefiderocol]]
-**[[Ceftazidime-avibactam]]
+*For AmpCs, consider: [[ceftazidime-avibactam]], [[meropenem-vaborbactam]]
 === Dosing ===

Aidan at 12:42, 30 August 2022

2022-08-30T12:42:28Z

← Older revision		Revision as of 12:42, 30 August 2022
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	**[[Imipenem-relebactam]]		**[[Imipenem-relebactam]]

			=== Dosing ===
			{\| class="wikitable"
			!Antimicrobial
			!Dose
			!Targetted Organisms
			\|-
			\|[[amikacin]]
			\|20 mg/kg IV load then per PK monitoring
			[[Cystitis]]: 15 mg/kg IV once
			\|ESBL-E, AmpC-E, CRE, DTR-PA
			\|-
			\|[[ampicillin-sulbactam]]
			\|9 g IV q8h infused over 4 h, or 27 g IV over 24 hours continuous infusion
			\|CRAB
			\|-
			\|[[cefepime]]
			\|2 g IV q8h infused over 2 h
			[[Cystitis]]: 1 g IV q8h
			\|AmpC-E
			\|-
			\|[[cefiderocol]]
			\|2 g IV q8h infused over 3 h
			\|CRE, DTR-PA, CRAB, Stenotrophomonas
			\|-
			\|[[ceftazidime-avibactam]]
			\|2.5 g IV q8h infused over 3 h
			\|CRE, DTR-PA
			\|-
			\|[[ceftazidime-avibactam]] plus [[aztreonam]]
			\|2.5 g IV q8h infused over 3 h plus 2 g IV q8h infused over 3 h, infused concurrently if possible
			\|MBL CRE, Stenotrophomonas
			\|-
			\|[[ceftolozane-tazobactam]]
			\|3 g IV q8h infused over 3 h
			[[Cystitis]]: 1.5 g IV q8h infused over 1 h
			\|DTR-PA
			\|-
			\|[[ciprofloxacin]]
			\|400 mg IV q8-12h or 500-750 mg p.o. q12h
			\|ESBL-E, AmpC-E
			\|-
			\|[[colistin]]
			\|
			\|CRE cystitis, DTR-PA cystitis, CRAB cystitis
			\|-
			\|[[eravacycline]]
			\|1 mg/kg IV q12h
			\|CRE, CRAB
			\|-
			\|[[ertapenem]]
			\|1 g IV q24h infused over 30 min
			\|ESBL-E, AmpC-E
			\|-
			\|[[fosfomycin]]
			\|[[Cystitis]]: 3 g p.o. once
			\|ESBL-E. coli cystitis
			\|-
			\|[[gentamicin]]
			\|7 mg/kg IV load then based on PK
			[[Cystitis]]: 5 mg/kg IV once
			\|ESBL-E, AmpC-, CRE, DTR-PA
			\|-
			\|[[imipenem-cilastatin]]
			\|ESBL-E or AmpC-E: 500 mg IV q6h infused over 30 min
			CRE and CRAB: 500 mg IV q6h infused over 3 h
			[[Cystitis]]: 500 mg IV q6h infused over 30 min
			\|ESBL-E, AmpC-E, CRE, CRAB
			\|-
			\|[[imipenem-cilastatin-relebactam]]
			\|1.25 g IV q6h infused over 30 min
			\|CRE, DTR-PA
			\|-
			\|[[levofloxacin]]
			\|750 mg p.o./IV q24h
			\|ESBL-E, AmpC-E, Stenotrophomonas
			\|-
			\|[[meropenem]]
			\|ESBL-E or AmpC-E: 1-2 g IV q8h infused over 30 min
			CRE and CRAB: 2 g IV q8h infused over 30 min
			[[Cystitis]]: 1 g IV q8h, infused over 30 min
			\|ESBL-E, AmpC-E, CRE, CRAB
			\|-
			\|[[meropenem-vaborbactam]]
			\|4 g IV q8h infused over 3 h
			\|CRE
			\|-
			\|[[minocycline]]
			\|200 mg IV/p.o. q12h
			\|CRAB, Stenotrophomonas
			\|-
			\|[[nitrofurantoin]]
			\|cystitis: macrocystals 100 mg p.o. q12h or oral suspension 50 mg p.o. q6h
			\|ESBL-E cystitis, AmpC-E cystitis
			\|-
			\|[[plazomicin]]
			\|15 mg/kg IV load then dosed by PK
			[[Cystitis]]: 15 mg/kg IV once
			\|ESBL-E, AmpC-E, CRE, DTR-PA
			\|-
			\|[[polymyxin B]]
			\|
			\|DTR-PA, CRAB
			\|-
			\|[[tigecycline]]
			\|200 mg IV load followed by 100 mg IV q12h
			\|CRE, CRAB, Stenotrophomonas
			\|-
			\|[[tobramycin]]
			\|7 mg/kg IV load then dosed by PK
			[[Cystitis]]: 5 mg/kg IV once
			\|ESBL-E, AmpC-E, CRE, DTR-PA
			\|-
			\|[[co-trimoxazole]]
			\|8-12 mg/kg/day (TMP) p.o./IV divided 18-12h
			[[Cystitis]]: 160 mg (TMP) p.o./IV q12h
			\|ESBL-E, AmpC-E, Stenotrophomonas
			\|}
	[[Category:Bacteria]]		[[Category:Bacteria]]

Aidan: /* Management */

2020-09-21T12:16:15Z

Management

@@ Line 101: / Line 101: @@
 | style="color:darkgreen;text-align:center" | +
 |}
 [[Category:Bacteria]]

Aidan at 12:15, 21 September 2020

2020-09-21T12:15:17Z

← Older revision		Revision as of 12:15, 21 September 2020
Line 1:		Line 1:
	== Background ==		==Background==

	* Mechanisms include decreased expression of porins, increased expression of efflux pumps, and [[carbapenemases]]		*Mechanisms include decreased expression of porins, increased expression of efflux pumps, and [[carbapenemases]]

	== Management ==		==Management==

	=== Novel Antibiotics ===
	{\| class="wikitable"		{\| class="wikitable"
	!Antibiotic		!Antibiotic
Line 103:		Line 101:
	\| style="color:darkgreen;text-align:center" \| +		\| style="color:darkgreen;text-align:center" \| +
	\|}		\|}
		⚫	[[Category:Bacteria]]

⚫	[[Category:~~Antibiotics~~]]

Aidan: Created page with "== Background == * Mechanisms include decreased expression of porins, increased expression of efflux pumps, and carbapenemases == Management == === Novel Antibiotics ==..."

2020-09-21T12:14:54Z

Created page with "== Background == * Mechanisms include decreased expression of porins, increased expression of efflux pumps, and carbapenemases == Management == === Novel Antibiotics ==..."

New page

== Background ==

* Mechanisms include decreased expression of porins, increased expression of efflux pumps, and [[carbapenemases]]

== Management ==

=== Novel Antibiotics ===
{| class="wikitable"
!Antibiotic
!KPC
!NDM
!OXA-48
!CRPsA
!CRAcB
!Stenotrophomonas
|-
|[[aztreonam-avibactam]]
| style="color:darkgreen;text-align:center" | +
| style="color:darkgreen;text-align:center" | +
| style="color:darkgreen;text-align:center" | +
| style="color:goldenrod;text-align:center" |±
| style="color:darkred;text-align:center" |–
| style="color:darkgreen;text-align:center" | +
|-
|[[cefiderocol]]
| style="color:darkgreen;text-align:center" | +
| style="color:darkgreen;text-align:center" | +
| style="color:darkgreen;text-align:center" | +
| style="color:darkgreen;text-align:center" | +
| style="color:darkgreen;text-align:center" | +
| style="color:darkgreen;text-align:center" | +
|-
|[[ceftazidime-avibactam]]
| style="color:darkgreen;text-align:center" | +
| style="color:darkred;text-align:center" |–
| style="color:darkgreen;text-align:center" | +
| style="color:goldenrod;text-align:center" |±
| style="color:darkred;text-align:center" |–
| style="color:darkred;text-align:center" |–
|-
|[[ceftolozane-tazobactam]]
| style="color:darkred;text-align:center" |–
| style="color:darkred;text-align:center" |–
| style="color:darkred;text-align:center" |–
| style="color:goldenrod;text-align:center" |±
| style="color:darkred;text-align:center" |–
| style="color:goldenrod;text-align:center" |±
|-
|[[eravacycline]]
| style="color:darkgreen;text-align:center" | +
| style="color:darkgreen;text-align:center" | +
| style="color:darkgreen;text-align:center" | +
| style="color:darkred;text-align:center" |–
| style="color:darkgreen;text-align:center" | +
| style="color:darkgreen;text-align:center" | +
|-
|[[fosfomycin]]
| style="color:goldenrod;text-align:center" |±
| style="color:goldenrod;text-align:center" |±
| style="color:goldenrod;text-align:center" |±
| style="color:goldenrod;text-align:center" |±
| style="color:darkred;text-align:center" |–
| style="color:darkred;text-align:center" |–
|-
|[[imipenem-relebactam]]
| style="color:darkgreen;text-align:center" | +
| style="color:darkred;text-align:center" |–
| style="color:goldenrod;text-align:center" |±
| style="color:darkgreen;text-align:center" | +
| style="color:darkred;text-align:center" |–
| style="color:darkred;text-align:center" |–
|-
|[[meropenem-vaborbactam]]
| style="color:darkgreen;text-align:center" | +
| style="color:darkred;text-align:center" |–
| style="color:darkred;text-align:center" |–
| style="color:darkred;text-align:center" |–
| style="color:darkred;text-align:center" |–
| style="color:darkred;text-align:center" |–
|-
|[[plazomicin]]
| style="color:darkgreen;text-align:center" | +
| style="color:goldenrod;text-align:center" |±
| style="color:darkgreen;text-align:center" | +
| style="color:goldenrod;text-align:center" |±
| style="color:darkred;text-align:center" |–
| style="color:darkred;text-align:center" |–
|-
|[[colistin]]
| style="color:goldenrod;text-align:center" |±
| style="color:goldenrod;text-align:center" |±
| style="color:goldenrod;text-align:center" |±
| style="color:goldenrod;text-align:center" |±
| style="color:goldenrod;text-align:center" |±
| style="color:goldenrod;text-align:center" |±
|-
|[[tigecycline]]
| style="color:darkgreen;text-align:center" | +
| style="color:darkgreen;text-align:center" | +
| style="color:darkgreen;text-align:center" | +
| style="color:darkred;text-align:center" |–
| style="color:darkgreen;text-align:center" | +
| style="color:darkgreen;text-align:center" | +
|}

[[Category:Antibiotics]]