Burkholderia cepacia complex - Revision history

Aidan: /* Clinical Manifestations */

2023-02-06T16:48:37Z

Clinical Manifestations

← Older revision		Revision as of 16:48, 6 February 2023
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	* Colonizes the lungs of patients with [[cystic fibrosis]] and portends a poor prognosis		* Colonizes the lungs of patients with [[cystic fibrosis]] and portends a poor prognosis
	* Occasionally causes nosocomial outbreaks traced back to aqueous pharmaceutical products		* Occasionally causes nosocomial outbreaks traced back to aqueous pharmaceutical products
			* Also causes hospital- or ventilator-associated [[pneumonia]], [[bacteremia]] (possibly [[CLABSI]]), [[ecthyma gangrenosum]], [[burn infection]], wound infection, [[endophthalmitis]], and rarely [[endocarditis]]

	== Management ==		== Management ==
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	* Antibiotic options include:		* Antibiotic options include:
	** [[TMP-SMX]] (preferred, if susceptible)		** [[TMP-SMX]] (preferred, if susceptible)
	** [[Ceftazidime]] and [[ceftazidime-avibactam]]		** [[Ceftazidime]] 2 g IV q8h and [[ceftazidime-avibactam]] 2.5 g IV q8h
	** [[Meropenem]] and [[imipenem]]		** [[Meropenem]] 1-2 g IV q8h and [[imipenem]] 1 g IV q8h
	** [[Minocycline]]		** [[Minocycline]] 100 mg p.o.IV q12h

	{{DISPLAYTITLE:''Burkholderia cepacia'' complex}}		{{DISPLAYTITLE:''Burkholderia cepacia'' complex}}

Aidan: /* Clinical Manifestations */

2023-02-06T16:44:51Z

Clinical Manifestations

← Older revision		Revision as of 16:44, 6 February 2023
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	** [[Burkholderia multivorans]] (genomovar II)		** [[Burkholderia multivorans]] (genomovar II)
	** [[Burkholderia dolosa]] (genomovar VI)		** [[Burkholderia dolosa]] (genomovar VI)
			* Environmental organism
	* Multiple mechanisms of resistance:		* Multiple mechanisms of resistance:
	** β-lactamases		** β-lactamases
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	* Opportunistic lung infections, primarily of [[cystic fibrosis]] and [[lung transplant]] patients		* Opportunistic lung infections, primarily of [[cystic fibrosis]] and [[lung transplant]] patients
	* Colonizes the lungs of patients with [[cystic fibrosis]] and portends a poor prognosis		* Colonizes the lungs of patients with [[cystic fibrosis]] and portends a poor prognosis
			* Occasionally causes nosocomial outbreaks traced back to aqueous pharmaceutical products

	== Management ==		== Management ==

Aidan at 16:42, 6 February 2023

2023-02-06T16:42:59Z

← Older revision		Revision as of 16:42, 6 February 2023
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	** [[Minocycline]]		** [[Minocycline]]

	{{DISPLAYTITLE:''Burkholderia cepacia''}}		{{DISPLAYTITLE:''Burkholderia cepacia'' complex}}
	[[Category:Infectious diseases]]		[[Category:Infectious diseases]]
	[[Category:Gram-negative bacilli]]		[[Category:Gram-negative bacilli]]

Aidan: Aidan moved page Burkholderia cepacia to Burkholderia cepacia complex without leaving a redirect

2023-02-06T16:42:41Z

Aidan moved page Burkholderia cepacia to Burkholderia cepacia complex without leaving a redirect

← Older revision	Revision as of 16:42, 6 February 2023
(No difference)

Aidan at 16:42, 6 February 2023

2023-02-06T16:42:30Z

← Older revision		Revision as of 16:42, 6 February 2023
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	* [[Stain::Gram-negative]] [[Shape::bacillus]]		* [[Stain::Gram-negative]] [[Shape::bacillus]]
			* Classified into nine genomovars (phenotypically similar but genotypically distinct)
			** [[Burkholderia cenocepacia]] (genomovar III)
			** [[Burkholderia multivorans]] (genomovar II)
			** [[Burkholderia dolosa]] (genomovar VI)
	* Multiple mechanisms of resistance:		* Multiple mechanisms of resistance:
	** β-lactamases		** β-lactamases
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	** Altered LPS conferring polymixin resistance		** Altered LPS conferring polymixin resistance
	** Gyrase mutations conferring fluoroquinolone resistance		** Gyrase mutations conferring fluoroquinolone resistance

			== Clinical Manifestations ==

			* Opportunistic lung infections, primarily of [[cystic fibrosis]] and [[lung transplant]] patients
			* Colonizes the lungs of patients with [[cystic fibrosis]] and portends a poor prognosis

	== Management ==		== Management ==

Aidan: Text replacement - "[[Cellular shape::" to "[[Shape::"

2020-10-13T17:56:17Z

Text replacement - "[[Cellular shape::" to "[[Shape::"

← Older revision		Revision as of 17:56, 13 October 2020
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	== Background ==		== Background ==

	* [[Stain::Gram-negative]] [[~~Cellular shape~~::bacillus]]		* [[Stain::Gram-negative]] [[Shape::bacillus]]
	* Multiple mechanisms of resistance:		* Multiple mechanisms of resistance:
	** β-lactamases		** β-lactamases

Aidan: Created page with "== Background == * Stain::Gram-negative Cellular shape::bacillus * Multiple mechanisms of resistance: β-lactamases RND efflux pumps ** Altered LPS conferring p..."

2020-08-15T15:17:23Z

Created page with "== Background == * Stain::Gram-negative Cellular shape::bacillus * Multiple mechanisms of resistance: ** β-lactamases ** RND efflux pumps ** Altered LPS conferring p..."

New page

== Background ==

* [[Stain::Gram-negative]] [[Cellular shape::bacillus]]
* Multiple mechanisms of resistance:
** β-lactamases
** RND efflux pumps
** Altered LPS conferring polymixin resistance
** Gyrase mutations conferring fluoroquinolone resistance

== Management ==

* Should be guided by antimicrobial susceptibility testing
* Antibiotic options include:
** [[TMP-SMX]] (preferred, if susceptible)
** [[Ceftazidime]] and [[ceftazidime-avibactam]]
** [[Meropenem]] and [[imipenem]]
** [[Minocycline]]

{{DISPLAYTITLE:''Burkholderia cepacia''}}
[[Category:Infectious diseases]]
[[Category:Gram-negative bacilli]]

Burkholderia cepacia complex - Revision history

Aidan: /* Clinical Manifestations */

Aidan: /* Clinical Manifestations */

Aidan at 16:42, 6 February 2023

Aidan: Aidan moved page Burkholderia cepacia to Burkholderia cepacia complex without leaving a redirect

Aidan at 16:42, 6 February 2023

Aidan: Text replacement - "[[Cellular shape::" to "[[Shape::"

Aidan: Created page with "== Background == * Stain::Gram-negative Cellular shape::bacillus * Multiple mechanisms of resistance: ** β-lactamases ** RND efflux pumps ** Altered LPS conferring p..."

Aidan: Created page with "== Background == * Stain::Gram-negative Cellular shape::bacillus * Multiple mechanisms of resistance: β-lactamases RND efflux pumps ** Altered LPS conferring p..."