Balamuthia mandrillaris - Revision history

Aidan: /* Clinical Manifestations */

2020-09-17T13:09:25Z

Clinical Manifestations

← Older revision		Revision as of 13:09, 17 September 2020
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	==Background==		==Background==
	===Microbiology===		===Microbiology===

	* One of the [[free-living amoebae]]		*One of the [[free-living amoebae]]

	===Epidemiology===		===Epidemiology===

	* Present in soil		*Present in soil
⚫	* More common in ~~US and South America~~
	* More common in ~~Hispanics~~		*More common in US and South America
		⚫	*More common in Hispanics

	==Clinical Manifestations==		==Clinical Manifestations==

	* Causes '''granulomatous amebic encephalitis (GAE)''' alone, skin lesions followed by GAE, or (rarely) skin lesions alone		*Causes '''granulomatous amebic encephalitis (GAE)''' alone, skin lesions followed by GAE, or (rarely) skin lesions alone
	** Characterized by progressive hemorrhagic necrosis of brain, with 90% mortality		**Characterized by progressive hemorrhagic necrosis of brain, with 90% mortality
	** Fever, headache, altered mentation), vomiting, lethargy, seizures, and weakness		**Fever, headache, altered mentation, vomiting, lethargy, seizures, and weakness
	* Often preceded by skin lesions by a few weeks to 2 years		*Often preceded by skin lesions by a few weeks to 2 years
	** Typically affect the nose and cheeks, but also torso and limbs		**Typically affect the nose and cheeks, but also torso and limbs
	** Often a single lesion		**Often a single lesion
	** Progress over months from papulonodular erythematous plate-like areas, enlarging and eventually ulcerating		**Progress over months from papulonodular erythematous plate-like areas, enlarging and eventually ulcerating
	** Typically painless		**Typically painless
	* Can also initially present with rhinitis, sinusitis, or otitis media		*Can also initially present with rhinitis, sinusitis, or otitis media
	* Difficult to treat, with high mortality		*Difficult to treat, with high mortality

	==Management==		==Management==

	* Based on case reports		*Based on case reports
	* Combination therapy recommended by CDC:		*Combination therapy recommended by CDC:
	** [[Is treated by::Pentamidine]] 4 mg/kg IV once daily
	** [[Is treated by::~~Sulfadiazine~~]] ~~1.5~~ g PO ~~q6h~~		**[[Is treated by::Pentamidine]] 4 mg/kg IV once daily
	** [[Is treated by::~~Flucytosine~~]] 37.5 ~~mg/kg~~ PO q6h		**[[Is treated by::Sulfadiazine]] 1.5 g PO q6h
	** [[Is treated by::~~Fluconazole~~]] 12 mg/kg PO~~/IV once~~ ~~daily~~		**[[Is treated by::Flucytosine]] 37.5 mg/kg PO q6h
	** [[Is treated by::~~Azithromycin~~]] 20 mg/kg ~~(max 500 mg)~~ PO once daily ~~(or [[Is treated by::clarithromycin]]~~		**[[Is treated by::Fluconazole]] 12 mg/kg PO/IV once daily
	** [[Is treated by::~~Miltefosine~~]] 50 mg ~~PO tid~~ (if ~~≥45~~ kg) or ~~bid~~ (if ~~<45~~ ~~kg)~~		**[[Is treated by::Azithromycin]] 20 mg/kg (max 500 mg) PO once daily (or [[Is treated by::clarithromycin]]
			**[[Is treated by::Miltefosine]] 50 mg PO tid (if ≥45 kg) or bid (if <45 kg)
	{{DISPLAYTITLE:''Balamuthia mandrillaris''}}		{{DISPLAYTITLE:''Balamuthia mandrillaris''}}
	[[Category:Protozoa]]		[[Category:Protozoa]]

Aidan: Text replacement - "Clinical Presentation" to "Clinical Manifestations"

2020-07-19T12:16:47Z

Text replacement - "Clinical Presentation" to "Clinical Manifestations"

← Older revision		Revision as of 12:16, 19 July 2020
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	* More common in Hispanics		* More common in Hispanics

	==Clinical ~~Presentation~~==		==Clinical Manifestations==
	* Causes '''granulomatous amebic encephalitis (GAE)''' alone, skin lesions followed by GAE, or (rarely) skin lesions alone		* Causes '''granulomatous amebic encephalitis (GAE)''' alone, skin lesions followed by GAE, or (rarely) skin lesions alone
	** Characterized by progressive hemorrhagic necrosis of brain, with 90% mortality		** Characterized by progressive hemorrhagic necrosis of brain, with 90% mortality

Aidan: added management

2020-06-04T02:21:24Z

added management

← Older revision		Revision as of 02:21, 4 June 2020
Line 20:		Line 20:
	* Difficult to treat, with high mortality		* Difficult to treat, with high mortality

			==Management==
			* Based on case reports
			* Combination therapy recommended by CDC:
			** [[Is treated by::Pentamidine]] 4 mg/kg IV once daily
			** [[Is treated by::Sulfadiazine]] 1.5 g PO q6h
			** [[Is treated by::Flucytosine]] 37.5 mg/kg PO q6h
			** [[Is treated by::Fluconazole]] 12 mg/kg PO/IV once daily
			** [[Is treated by::Azithromycin]] 20 mg/kg (max 500 mg) PO once daily (or [[Is treated by::clarithromycin]]
			** [[Is treated by::Miltefosine]] 50 mg PO tid (if ≥45 kg) or bid (if <45 kg)
	{{DISPLAYTITLE:''Balamuthia mandrillaris''}}		{{DISPLAYTITLE:''Balamuthia mandrillaris''}}
	[[Category:Protozoa]]		[[Category:Protozoa]]

Aidan: /* Clinical Presentation */

2020-06-04T02:18:15Z

Clinical Presentation

← Older revision		Revision as of 02:18, 4 June 2020
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	** Characterized by progressive hemorrhagic necrosis of brain, with 90% mortality		** Characterized by progressive hemorrhagic necrosis of brain, with 90% mortality
	** Fever, headache, altered mentation), vomiting, lethargy, seizures, and weakness		** Fever, headache, altered mentation), vomiting, lethargy, seizures, and weakness
	* Often preceded by skin lesions, ~~typically~~ ~~affecting~~ ~~the~~ ~~nose~~ ~~and~~ ~~cheeks,~~ ~~that can progress over months~~		* Often preceded by skin lesions by a few weeks to 2 years
			** Typically affect the nose and cheeks, but also torso and limbs
			** Often a single lesion
			** Progress over months from papulonodular erythematous plate-like areas, enlarging and eventually ulcerating
			** Typically painless
			* Can also initially present with rhinitis, sinusitis, or otitis media
	* Difficult to treat, with high mortality		* Difficult to treat, with high mortality

Aidan: /* Clinical Presentation */

2020-06-03T23:59:45Z

Clinical Presentation

← Older revision		Revision as of 23:59, 3 June 2020
Line 10:		Line 10:
	==Clinical Presentation==		==Clinical Presentation==
	* Causes '''granulomatous amebic encephalitis (GAE)''' alone, skin lesions followed by GAE, or (rarely) skin lesions alone		* Causes '''granulomatous amebic encephalitis (GAE)''' alone, skin lesions followed by GAE, or (rarely) skin lesions alone
	* ~~GAE is characterized~~ by progressive hemorrhagic necrosis of brain, with 90% mortality		** Characterized by progressive hemorrhagic necrosis of brain, with 90% mortality
			** Fever, headache, altered mentation), vomiting, lethargy, seizures, and weakness
	* Often preceded by skin lesions, typically affecting the nose and cheeks, that can progress over months		* Often preceded by skin lesions, typically affecting the nose and cheeks, that can progress over months
	* Difficult to treat, with high mortality		* Difficult to treat, with high mortality

Aidan at 23:51, 3 June 2020

2020-06-03T23:51:36Z

← Older revision		Revision as of 23:51, 3 June 2020
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			==Background==
	* Environmental protozoan parasite that causes '''granulomatous amebic encephalitis (GAE)'''
			===Microbiology===
⚫	* GAE is characterized by progressive hemorrhagic necrosis of brain
			* One of the [[free-living amoebae]]

			===Epidemiology===
			* Present in soil
			* More common in US and South America
			* More common in Hispanics

			==Clinical Presentation==
			* Causes '''granulomatous amebic encephalitis (GAE)''' alone, skin lesions followed by GAE, or (rarely) skin lesions alone
		⚫	* GAE is characterized by progressive hemorrhagic necrosis of brain, with 90% mortality
			* Often preceded by skin lesions, typically affecting the nose and cheeks, that can progress over months
			* Difficult to treat, with high mortality

	{{DISPLAYTITLE:''Balamuthia mandrillaris''}}		{{DISPLAYTITLE:''Balamuthia mandrillaris''}}

Aidan: Created page with "* Environmental protozoan parasite that causes '''granulomatous amebic encephalitis (GAE)''' * GAE is characterized by progressive hemorrhagic necrosis of brain {{DISPLAYTITL..."

2019-08-29T02:48:15Z

Created page with "* Environmental protozoan parasite that causes '''granulomatous amebic encephalitis (GAE)''' * GAE is characterized by progressive hemorrhagic necrosis of brain {{DISPLAYTITL..."

New page

* Environmental protozoan parasite that causes '''granulomatous amebic encephalitis (GAE)'''
* GAE is characterized by progressive hemorrhagic necrosis of brain

{{DISPLAYTITLE:''Balamuthia mandrillaris''}}
[[Category:Protozoa]]