Antiretroviral resistance in HIV - Revision history

Aidan: Aidan moved page Antiretroviral resistance to Antiretroviral resistance in HIV

2020-10-22T12:59:18Z

Aidan moved page Antiretroviral resistance to Antiretroviral resistance in HIV

← Older revision		Revision as of 12:59, 22 October 2020
(No difference)

Aidan: /* All Mutations */

2020-08-28T12:44:41Z

All Mutations

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Aidan: /* All Mutations */

2020-08-28T12:34:53Z

All Mutations

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Aidan at 12:20, 28 August 2020

2020-08-28T12:20:26Z

@@ Line 3: / Line 3: @@
 *Bulk sequencing can only detect mutations that represent >20% of HIV
 {| class="wikitable"
 !Drug

Aidan at 11:56, 28 August 2020

2020-08-28T11:56:53Z

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Aidan at 20:25, 5 July 2020

2020-07-05T20:25:49Z

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Aidan at 20:12, 5 July 2020

2020-07-05T20:12:18Z

← Older revision		Revision as of 20:12, 5 July 2020
Line 233:		Line 233:
	\| L 89 V		\| L 89 V
	\|-		\|-
	! colspan=2 \| ~~I N S T Is~~		! colspan=2 \| INSTIs
	\|-		\|-
	\| rowspan=5 \| [[Bictegravir]]		\| rowspan=5 \| [[Bictegravir]]

Aidan at 20:06, 5 July 2020

2020-07-05T20:06:55Z

← Older revision		Revision as of 20:06, 5 July 2020
Line 35:		Line 35:
	\| Q '''151''' '''M'''		\| Q '''151''' '''M'''
	\|-		\|-
	\| rowspan=6 \| Thymidine analogue-associated mutations (~~T A Ms~~) multi-NRTI resistance		\| rowspan=6 \| Thymidine analogue-associated mutations (TAMs) multi-NRTI resistance
	\| M '''41''' '''L'''		\| M '''41''' '''L'''
	\|-		\|-

Aidan: Created page with "* Genotyping sequences reverse transcriptase, integrase, and protease * Resistance point mutations names as wild-type amino acid, position, and mutant amino acid (e.g. K '''10..."

2020-06-11T15:09:10Z

Created page with "* Genotyping sequences reverse transcriptase, integrase, and protease * Resistance point mutations names as wild-type amino acid, position, and mutant amino acid (e.g. K '''10..."

New page

* Genotyping sequences reverse transcriptase, integrase, and protease
* Resistance point mutations names as wild-type amino acid, position, and mutant amino acid (e.g. K '''103''' N)
* Bulk sequencing can only detect mutations that represent >20% of HIV

{| class="wikitable"
! Drug
! Mutation
|-
! colspan=2 | NRTIs
|-
| rowspan=7 | 69 insertion complex multi-NRTI resistance
| M '''41''' '''L'''
|-
| A '''62''' '''V'''
|-
| * '''69''' '''insert'''
|-
| K '''70''' '''R'''
|-
| L '''210''' '''W'''
|-
| T '''215''' '''Y F'''
|-
| K '''219''' '''Q E'''
|-
| rowspan=5 | 151 complex multi-NRTI resistance
| A '''62''' '''V'''
|-
| V '''75''' '''I'''
|-
| F '''77''' '''L'''
|-
| F '''116''' '''Y'''
|-
| Q '''151''' '''M'''
|-
| rowspan=6 | Thymidine analogue-associated mutations (T A Ms) multi-NRTI resistance
| M '''41''' '''L'''
|-
| D '''67''' '''N'''
|-
| K '''70''' '''R'''
|-
| L '''210''' '''W'''
|-
| T '''215''' '''Y F'''
|-
| K '''219''' '''Q W'''
|-
| rowspan=4 | [[Abacavir]]
| K '''65''' '''R E N'''
|-
| L '''74''' '''V'''
|-
| Y '''115''' '''F'''
|-
| M '''184''' '''V'''
|-
| rowspan=2 | [[Emtricitabine]]
| K '''65''' '''R E N'''
|-
| M '''184''' '''V I'''
|-
| rowspan=2 | [[Lamivudine]]
| K '''65 '''R E N'''
|-
| M '''184''' '''V I'''
|-
| rowspan=2 | [[Tenofovir]]
| K '''65''' '''R E N'''
|-
| K '''70''' '''E'''
|-
| rowspan=6 | [[Zidovudine]]
| M '''41''' '''L'''
|-
| D '''67''' '''N'''
|-
| K '''70''' '''R'''
|-
| L '''210''' '''W'''
|-
| T '''215''' '''Y F'''
|-
| K '''219''' '''Q E'''
|-
! colspan=2 | NNRTIs
|-
| rowspan=7 | [[Doravirine]]
| V '''106''' '''A''' I '''M''' T
|-
| Y '''188''' C '''L''' H
|-
| G '''190''' E
|-
| P '''225''' H
|-
| F '''227''' C L R
|-
| M '''230''' L
|-
| L '''234''' I
|-
| rowspan=10 | [[Efavirenz]]
| L '''100''' '''I'''
|-
| K '''101''' '''P'''
|-
| K '''103''' '''N S'''
|-
| V '''106''' '''M'''
|-
| V '''108''' '''I'''
|-
| Y '''181''' '''C I'''
|-
| Y '''188''' '''L'''
|-
| G '''190''' '''S A'''
|-
| P '''225''' '''H'''
|-
| M '''230''' '''L'''
|-
| rowspan=9 | [[Nevirapine]]
| L '''100''' '''I'''
|-
| K '''101''' '''P'''
|-
| K '''103''' '''N S'''
|-
| V '''106''' '''A M'''
|-
| V '''108''' '''I'''
|-
| Y '''181''' '''C I'''
|-
| Y '''188''' '''C L H'''
|-
| G '''190''' '''A'''
|-
| M '''230''' '''L'''
|-
| rowspan=9 | [[Rilpivirine]]
| L '''100''' '''I'''
|-
| K '''101''' '''E P'''
|-
| E '''138''' '''A G K Q R'''
|-
| V '''179''' '''L'''
|-
| Y '''181''' '''C I V'''
|-
| Y '''188''' '''L'''
|-
| H '''221''' '''Y'''
|-
| F '''227''' '''C'''
|-
| M '''230''' '''I L'''
|-
! colspan=2 | Protease inhibitors
|-
| rowspan=24 | [[Atazanavir]]
| L '''10''' I F V C
|-
| G '''16''' E
|-
| K '''20''' R M I T V
|-
| L '''24''' I
|-
| V '''32''' I
|-
| L '''33''' I F V
|-
| E '''34''' Q
|-
| M '''36''' I L V
|-
| M '''46''' I L
|-
| G '''48''' V
|-
| I '''50''' '''L'''
|-
| F '''53''' L Y
|-
| I '''54''' L V M T A
|-
| D '''60''' E
|-
| I '''62''' V
|-
| I '''64''' L M V
|-
| A '''71''' V I T L
|-
| G '''73''' C S T A
|-
| V 82 A T F I
|-
| I '''84''' '''V'''
|-
| I 85 V
|-
| N '''88''' '''S'''
|-
| L 90 M
|-
| I 93 L M
|-
| rowspan=10 | [[Darunavir]]
| V 11 I
|-
| V 32 I
|-
| L 33 F
|-
| I '''47''' '''V'''
|-
| I '''50''' '''V'''
|-
| I '''54''' '''M L'''
|-
| T 74 P
|-
| L '''76''' '''V'''
|-
| I '''84''' '''V'''
|-
| L 89 V
|-
! colspan=2 | I N S T Is
|-
| rowspan=5 | [[Bictegravir]]
| G 118 R
|-
| E 138 K
|-
| G 140 S
|-
| Q '''148''' '''H'''
|-
| R '''263''' '''K'''
|-
| rowspan=8 | [[Cabotegravir]]
| T 66 K
|-
| G '''118''' '''R'''
|-
| E 138 A K T
|-
| G '''140''' A C '''R''' S
|-
| Q '''148''' '''H K R'''
|-
| S 153 F Y
|-
| N 155 H
|-
| R '''263''' '''K'''
|-
| rowspan=7 | [[Dolutegravir]]
| G '''118''' '''R'''
|-
| F 121 Y
|-
| E 138 A K T
|-
| G 140 A S
|-
| Q '''148''' '''H K R'''
|-
| N 155 H
|-
| R '''263''' '''K'''
|-
| rowspan=8 | [[Elvitegravir]]
| T '''66''' '''I''' A K
|-
| E '''92''' '''Q''' G
|-
| T 97 A
|-
| F '''121''' '''Y'''
|-
| S '''147''' '''G'''
|-
| Q '''148''' '''H K R'''
|-
| N '''155''' '''H'''
|-
| R '''263''' '''K'''
|-
| rowspan=10 | [[Raltegravir]]
| L 74 M
|-
| E 92 Q
|-
| T 97 A
|-
| F '''121''' '''Y'''
|-
| E 138 A K
|-
| G 140 A S
|-
| Y '''143''' '''R H C'''
|-
| Q '''148''' '''H K R'''
|-
| N '''155''' '''H'''
|-
| R '''263''' '''K'''
|}

[[Category:HIV]]