Antimicrobials in pregnancy - Revision history

Aidan: /* Specific Antimicrobials */

2026-02-09T13:29:24Z

Specific Antimicrobials

← Older revision		Revision as of 13:29, 9 February 2026
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	* [[Penicillins]], including [[amoxicillin]], [[ampicillin]]		* [[Penicillins]], including [[amoxicillin]], [[ampicillin]]
	* [[Cephalosporins]], including [[cefaclor]], [[cephalexin]], although they have been associated with [[kernicterus]] ([[~~ceftriaoxone~~]])		* [[Cephalosporins]], including [[cefaclor]], [[cephalexin]], although they have been associated with [[kernicterus]] ([[ceftriaxone]])
	* [[Azithromycin]], which is preferred to [[erythromycin]] and [[clindamycin]]		* [[Azithromycin]], which is preferred to [[erythromycin]] and [[clindamycin]]
	* [[Vancomycin]], [[daptomycin]], [[fidaxomicin]]		* [[Vancomycin]], [[daptomycin]], [[fidaxomicin]]

Aidan at 20:30, 6 February 2026

2026-02-06T20:30:46Z

← Older revision		Revision as of 20:30, 6 February 2026
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	* [[Aminoglycosides]]: streptomycin associated with hearing loss, while others may be used for short courses		* [[Aminoglycosides]]: streptomycin associated with hearing loss, while others may be used for short courses
	* [[Tetracyclines]] can discolor a developing baby's teeth and aren't recommended after the 15th week of pregnancy		* [[Tetracyclines]] can discolor a developing baby's teeth and aren't recommended after the 15th week of pregnancy
			* [[Fluconazole]] is associated with spontaneous abortion

	== Further Reading ==		== Further Reading ==

Aidan at 17:24, 30 May 2021

2021-05-30T17:24:57Z

← Older revision		Revision as of 17:24, 30 May 2021
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	* [[Aminoglycosides]]: streptomycin associated with hearing loss, while others may be used for short courses		* [[Aminoglycosides]]: streptomycin associated with hearing loss, while others may be used for short courses
	* [[Tetracyclines]] can discolor a developing baby's teeth and aren't recommended after the 15th week of pregnancy		* [[Tetracyclines]] can discolor a developing baby's teeth and aren't recommended after the 15th week of pregnancy

			== Further Reading ==

			* A Review of Antibiotic Use in Pregnancy. ''Pharmacotherapy''. 2015;35(11):1052-62. doi: [https://doi.org/10.1002/phar.1649 10.1002/phar.1649]

	[[Category:Antimicrobials]]		[[Category:Antimicrobials]]

Aidan: /* Specific Antimicrobials */

2021-05-30T17:23:38Z

Specific Antimicrobials

← Older revision		Revision as of 17:23, 30 May 2021
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	* [[Metronidazole]], though topical should be avoided		* [[Metronidazole]], though topical should be avoided
	* [[Fosfomycin]]		* [[Fosfomycin]]


	Avoid unless benefits outweight risks:		Avoid unless benefits outweight risks:
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	* [[Polymixins]]		* [[Polymixins]]
	* [[Cotrimoxazole]]: avoid in first trimester (congenital malformations), and after 32 weeks (risk of kernicterus); has been associated with [[diaphragmatic hernia]] and [[esophageal atresia]]		* [[Cotrimoxazole]]: avoid in first trimester (congenital malformations), and after 32 weeks (risk of kernicterus); has been associated with [[diaphragmatic hernia]] and [[esophageal atresia]]


	Should be avoided altogether:		Should be avoided altogether:

Aidan: Created page with "== Principles == * Use medications only if absolutely necessary * If possible, avoid therapy during the first trimester * Use a safe medication * Use the narrowest spectrum a..."

2021-05-30T17:23:15Z

Created page with "== Principles == * Use medications only if absolutely necessary * If possible, avoid therapy during the first trimester * Use a safe medication * Use the narrowest spectrum a..."

New page

== Principles ==

* Use medications only if absolutely necessary
* If possible, avoid therapy during the first trimester
* Use a safe medication
* Use the narrowest spectrum and shortest course
* When possible, use a single agent

== Specific Antimicrobials ==
Generally considered safe in pregnancy:

* [[Penicillins]], including [[amoxicillin]], [[ampicillin]]
* [[Cephalosporins]], including [[cefaclor]], [[cephalexin]], although they have been associated with [[kernicterus]] ([[ceftriaoxone]])
* [[Azithromycin]], which is preferred to [[erythromycin]] and [[clindamycin]]
* [[Vancomycin]], [[daptomycin]], [[fidaxomicin]]
* [[Nitrofurantoin]], although it has been associated with orofacial clefts including [[cleft lip]] and [[cleft palate]]
* [[Metronidazole]], though topical should be avoided
* [[Fosfomycin]]

Avoid unless benefits outweight risks:

* [[Fluoroquinolones]], based on animal data of bone and cartilage damage
* [[Linezolid]]
* [[Polymixins]]
* [[Cotrimoxazole]]: avoid in first trimester (congenital malformations), and after 32 weeks (risk of kernicterus); has been associated with [[diaphragmatic hernia]] and [[esophageal atresia]]

Should be avoided altogether:

* [[Tigecycline]]
* [[Aminoglycosides]]: streptomycin associated with hearing loss, while others may be used for short courses
* [[Tetracyclines]] can discolor a developing baby's teeth and aren't recommended after the 15th week of pregnancy

[[Category:Antimicrobials]]
[[Category:Obstetrical medicine]]