Antifungals - Revision history

Aidan: Text replacement - " species]]" to "]]"

2022-02-08T02:48:38Z

Text replacement - " species]]" to "]]"

← Older revision		Revision as of 02:48, 8 February 2022
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	*Mechanism: inhibit 14-alpha demethylase (aka. Cyp51p, encoded by Erg11 genes), which is required for synthesis of ergosterol from lanosterol, thus disrupting the cell wall.		*Mechanism: inhibit 14-alpha demethylase (aka. Cyp51p, encoded by Erg11 genes), which is required for synthesis of ergosterol from lanosterol, thus disrupting the cell wall.
	*Examples		*Examples
	**[[Fluconazole]]: Used as prophylaxis or treatment for [[Candida ~~species~~]]		**[[Fluconazole]]: Used as prophylaxis or treatment for [[Candida]]
	**[[Voriconazole]]: First-line treatment for [[invasive aspergillosis]]		**[[Voriconazole]]: First-line treatment for [[invasive aspergillosis]]
	**[[Itraconazole]]		**[[Itraconazole]]

Aidan at 23:31, 21 September 2020

2020-09-21T23:31:28Z

← Older revision		Revision as of 23:31, 21 September 2020
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	See also [[Antifungal spectrum of activity]]		See also [[Antifungal spectrum of activity]]

	== Polyenes ==		==Polyenes==

	* Mechanism: bind to ergosterol in the cell membrane and create pores		*Mechanism: bind to ergosterol in the cell membrane and create pores
	* Examples: [[Amphotericin B]]		*Examples: [[Amphotericin B]]

	== Triazoles ==		==Triazoles==

	* Mechanism: inhibit 14-alpha demethylase (aka. Cyp51p, encoded by Erg11 genes), which is required for synthesis of ergosterol from lanosterol, thus disrupting the cell wall.		*Mechanism: inhibit 14-alpha demethylase (aka. Cyp51p, encoded by Erg11 genes), which is required for synthesis of ergosterol from lanosterol, thus disrupting the cell wall.
	* Examples		*Examples
	** [[Fluconazole]]: Used as ~~aspergillosis~~ prophylaxis		**[[Fluconazole]]: Used as prophylaxis or treatment for [[Candida species]]
	** [[Voriconazole]]: First line treatment for invasive aspergillosis		**[[Voriconazole]]: First-line treatment for [[invasive aspergillosis]]
			**[[Itraconazole]]
	** [[Posaconazole]]: Second line treatment for invasive aspergillosis		**[[Posaconazole]]: Second-line treatment for [[invasive aspergillosis]], but first-line for prophylaxis
	*** Does not require adjustment in hepatic disease?
	** [[Isavuconazole]]		**[[Isavuconazole]]

	== Echinocandins ==		==Echinocandins==

	* Mechanism: disrupt synthesis of beta-glucan in the cell wall by inhibiting 1,3-beta glucan synthase		*Mechanism: disrupt synthesis of beta-glucan in the cell wall by inhibiting 1,3-beta glucan synthase
	* Examples		*Examples
	** [[Micafungin]]		**[[Micafungin]]
	** [[Caspofungin]]: Febrile neutropenia		**[[Caspofungin]]: Febrile neutropenia
	** [[Anidulafungin]]: ICU (high APACHEII), no renal or hepatic dosing needed		**[[Anidulafungin]]: ICU (high APACHEII), no renal or hepatic dosing needed

	[[Category:Antimicrobials]]		[[Category:Antimicrobials]]

Aidan at 11:03, 26 August 2020

2020-08-26T11:03:17Z

← Older revision		Revision as of 11:03, 26 August 2020
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	** [[Anidulafungin]]: ICU (high APACHEII), no renal or hepatic dosing needed		** [[Anidulafungin]]: ICU (high APACHEII), no renal or hepatic dosing needed

	[[Category:~~Antifungals~~]]		[[Category:Antimicrobials]]

Aidan at 19:36, 15 August 2019

2019-08-15T19:36:51Z

← Older revision		Revision as of 19:36, 15 August 2019
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	See also [[Antifungal spectrum of activity]]		See also [[Antifungal spectrum of activity]]

	= Polyenes =		== Polyenes ==

	* Mechanism: bind to ergosterol in the cell membrane and create pores		* Mechanism: bind to ergosterol in the cell membrane and create pores
	* Examples: [[Amphotericin B]]		* Examples: [[Amphotericin B]]

	= Triazoles =		== Triazoles ==

	* Mechanism: inhibit 14-alpha demethylase (aka. Cyp51p, encoded by Erg11 genes), which is required for synthesis of ergosterol from lanosterol, thus disrupting the cell wall.		* Mechanism: inhibit 14-alpha demethylase (aka. Cyp51p, encoded by Erg11 genes), which is required for synthesis of ergosterol from lanosterol, thus disrupting the cell wall.
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	** [[Isavuconazole]]		** [[Isavuconazole]]

	= Echinocandins =		== Echinocandins ==

	* Mechanism: disrupt synthesis of beta-glucan in the cell wall by inhibiting 1,3-beta glucan synthase		* Mechanism: disrupt synthesis of beta-glucan in the cell wall by inhibiting 1,3-beta glucan synthase

Aidan at 00:36, 15 August 2019

2019-08-15T00:36:36Z

← Older revision		Revision as of 00:36, 15 August 2019
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	See also [[Antifungal spectrum]]		See also [[Antifungal spectrum of activity]]

	= Polyenes =		= Polyenes =

Aidan at 00:36, 15 August 2019

2019-08-15T00:36:14Z

← Older revision		Revision as of 00:36, 15 August 2019
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		⚫	See also [[Antifungal spectrum]]
⚫	= Antifungals =

		⚫	= Polyenes =
⚫	See also [Antifungal spectrum]~~(Antifungal spectrum.md)~~

⚫	== Polyenes ==

	* Mechanism: bind to ergosterol in the cell membrane and create pores		* Mechanism: bind to ergosterol in the cell membrane and create pores
	* Examples: Amphotericin B		* Examples: [[Amphotericin B]]

	== Triazoles ==		= Triazoles =

	* Mechanism: inhibit 14-alpha demethylase (aka. Cyp51p, encoded by Erg11 genes), which is required for synthesis of ergosterol from lanosterol, thus disrupting the cell wall.		* Mechanism: inhibit 14-alpha demethylase (aka. Cyp51p, encoded by Erg11 genes), which is required for synthesis of ergosterol from lanosterol, thus disrupting the cell wall.
	* Examples		* Examples
	** Fluconazole: Used as aspergillosis prophylaxis		** [[Fluconazole]]: Used as aspergillosis prophylaxis
	** Voriconazole: First line treatment for invasive aspergillosis		** [[Voriconazole]]: First line treatment for invasive aspergillosis
	** Posaconazole: Second line treatment for invasive aspergillosis		** [[Posaconazole]]: Second line treatment for invasive aspergillosis
	*** Does not require adjustment in hepatic disease?		*** Does not require adjustment in hepatic disease?
			** [[Isavuconazole]]

	== Echinocandins ==		= Echinocandins =

	* Mechanism: disrupt synthesis of beta-glucan in the cell wall by inhibiting 1,3-beta glucan synthase		* Mechanism: disrupt synthesis of beta-glucan in the cell wall by inhibiting 1,3-beta glucan synthase
	* Examples		* Examples
	** Micafungin		** [[Micafungin]]
	** Caspofungin: Febrile neutropenia		** [[Caspofungin]]: Febrile neutropenia
	** Anidulafungin: ICU (high APACHEII), no renal or hepatic dosing needed		** [[Anidulafungin]]: ICU (high APACHEII), no renal or hepatic dosing needed

		⚫	[[Category:Antifungals]]

Maintenance script: Imported from text file

2019-08-11T17:58:14Z

Imported from text file

New page

= Antifungals =

See also [Antifungal spectrum](Antifungal spectrum.md)

== Polyenes ==

* Mechanism: bind to ergosterol in the cell membrane and create pores
* Examples: Amphotericin B

== Triazoles ==

* Mechanism: inhibit 14-alpha demethylase (aka. Cyp51p, encoded by Erg11 genes), which is required for synthesis of ergosterol from lanosterol, thus disrupting the cell wall.
* Examples
** Fluconazole: Used as aspergillosis prophylaxis
** Voriconazole: First line treatment for invasive aspergillosis
** Posaconazole: Second line treatment for invasive aspergillosis
*** Does not require adjustment in hepatic disease?

== Echinocandins ==

* Mechanism: disrupt synthesis of beta-glucan in the cell wall by inhibiting 1,3-beta glucan synthase
* Examples
** Micafungin
** Caspofungin: Febrile neutropenia
** Anidulafungin: ICU (high APACHEII), no renal or hepatic dosing needed