Anaplasma phagocytophilum - Revision history

Aidan: /* Clinical Manifestations */

2025-09-30T19:05:22Z

Clinical Manifestations

← Older revision		Revision as of 19:05, 30 September 2025
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	*Fever, headache, malaise, and myalgias are common		*Fever, headache, malaise, and myalgias are common
	*Can also cause nausea, vomiting, diarrhea, cough, arthralgias, nuchal rigidity, and confusion		*Can also cause nausea, vomiting, diarrhea, cough, arthralgias, nuchal rigidity, and confusion
	*Less than 10% have rash, most of which is concurrent Lyme disease		*Less than 10% have rash, most of which is concurrent [[Lyme disease]]
	*36% of cases require hospitalization, and it is severe in 3 to 7%		*36% of cases require hospitalization, and it is severe in 3 to 7%
	*Severe complications include respiratory failure, septic shock, rhabdomyolysis, hemorrhage, and opportunistic infections		*Severe complications include respiratory failure, septic shock, rhabdomyolysis, hemorrhage, and opportunistic infections

2023-07-08T16:23:49Z

← Older revision		Revision as of 16:23, 8 July 2023
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	*Transmitted by [[Vector::Ixodes scapularis]] and [[Vector::Ixodes pacificus]] ticks		*Transmitted by [[Vector::Ixodes scapularis]] and [[Vector::Ixodes pacificus]] ticks
	*Rare case reports in Ontario		*Rare case reports in Ontario
			*Transmission may take as little as 24 hours of tick attachment

	==Clinical Manifestations==		==Clinical Manifestations==

2022-09-22T22:06:14Z

Management

← Older revision		Revision as of 22:06, 22 September 2022
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	==Management==		==Management==

	*Doxycycline 100 mg po bid		*[[Doxycycline]] 100 mg po bid until at least 72 days after defervescence
			**Possibly 10 days if risk of concurrent [[Lyme disease]]

	{{DISPLAYTITLE:''Anaplasma phagocytophilum''}}		{{DISPLAYTITLE:''Anaplasma phagocytophilum''}}

2022-09-22T14:02:02Z

Epidemiology

← Older revision		Revision as of 14:02, 22 September 2022
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	*Transmitted by [[Vector::Ixodes scapularis]] and [[Vector::Ixodes pacificus]] ticks		*Transmitted by [[Vector::Ixodes scapularis]] and [[Vector::Ixodes pacificus]] ticks
			*Rare case reports in Ontario

	==Clinical Manifestations==		==Clinical Manifestations==

2020-08-05T13:47:10Z

@@ Line 1: / Line 1: @@
 * Causes '''human granulocytotropic anaplasmosis'''
-== Background ==
+===Microbiology===
-* Small, obligate intracellular Gram-negative bacterium
+*Small, obligate intracellular Gram-negative bacterium
-* Related to ''[[Ehrlichia]]'' and ''[[Rickettsiae]]''
+*Related to ''[[Ehrlichia]]'' and ''[[Rickettsiae]]''
-* Tropism for neutrophils
+*Tropism for neutrophils
-== Epidemiology ==
+==Diagnosis==
-== Diagnosis ==
+==Management==
 {{DISPLAYTITLE:''Anaplasma phagocytophilum''}}

2020-08-05T13:46:29Z

Clinical Manifestations

← Older revision		Revision as of 13:46, 5 August 2020
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	== Clinical Manifestations ==		== Clinical Manifestations ==
	* Incubation period of 1 to 2 weeks		* Incubation period of [[Usual incubation period::1 to 2 weeks]]
	* Usually an acute undifferentiated fever		* Usually an acute undifferentiated fever
	* Can be mild or severe		* Can be mild or severe

2020-07-20T19:30:50Z

Text replacement - "Clinical Presentation" to "Clinical Manifestations"

← Older revision		Revision as of 19:30, 20 July 2020
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	* Transmitted by ''[[Ixodes scapularis]]'' and ''[[Ixodes pacificus]]'' ticks		* Transmitted by ''[[Ixodes scapularis]]'' and ''[[Ixodes pacificus]]'' ticks

	== Clinical ~~Presentation~~ ==		== Clinical Manifestations ==
	* Incubation period of 1 to 2 weeks		* Incubation period of 1 to 2 weeks
	* Usually an acute undifferentiated fever		* Usually an acute undifferentiated fever

2020-02-05T02:22:13Z

Clinical Presentation: typo

← Older revision		Revision as of 02:22, 5 February 2020
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	** Rare meningoencephalitis		** Rare meningoencephalitis
	* Higher case-fatality rate in Shandong Province in China, for no clear reason (16% versus 2.6%)		* Higher case-fatality rate in Shandong Province in China, for no clear reason (16% versus 2.6%)
	* Thrombocytopenia, ~~lerkopenia~~, and mild anemia are common		* Thrombocytopenia, leukopenia, and mild anemia are common
	** Return to normal range within 14 days, but with persistent left shift		** Return to normal range within 14 days, but with persistent left shift
	* Abnormal liver enzymes are common in the first 7 days		* Abnormal liver enzymes are common in the first 7 days

2020-02-05T02:20:42Z

Microbiology: style

← Older revision		Revision as of 02:20, 5 February 2020
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	=== Microbiology ===		=== Microbiology ===
	* Small, obligate intracellular Gram-negative bacterium		* Small, obligate intracellular Gram-negative bacterium
	* Related to [[Ehrlichia]] and [[Rickettsiae]]		* Related to ''[[Ehrlichia]]'' and ''[[Rickettsiae]]''
	* Tropism for neutrophils		* Tropism for neutrophils

2020-01-27T20:22:02Z

added vector

← Older revision		Revision as of 20:22, 27 January 2020
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	* Causes '''human granulocytotropic anaplasmosis'''		* Causes '''human granulocytotropic anaplasmosis'''

	== ~~Microbiology~~ ==		== Background ==
			=== Microbiology ===

	* Small, obligate intracellular Gram-negative bacterium		* Small, obligate intracellular Gram-negative bacterium
	* Related to Ehrlichia and Rickettsiae		* Related to [[Ehrlichia]] and [[Rickettsiae]]
	* Tropism for neutrophils		* Tropism for neutrophils

			== Epidemiology ==
			* Transmitted by ''[[Ixodes scapularis]]'' and ''[[Ixodes pacificus]]'' ticks

	== Clinical Presentation ==		== Clinical Presentation ==

	* Incubation period of 1 to 2 weeks		* Incubation period of 1 to 2 weeks
	* Usually an acute undifferentiated fever		* Usually an acute undifferentiated fever
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	== Diagnosis ==		== Diagnosis ==

	* 20-80% of patients will have circulating neutrophils with detectable '''morulae''' on blood film (in neutrophils/granulocytes)		* 20-80% of patients will have circulating neutrophils with detectable '''morulae''' on blood film (in neutrophils/granulocytes)
	* Serology used to diagnose, by measuring IgG levels ≥1:64 or a fourfold rise		* Serology used to diagnose, by measuring IgG levels ≥1:64 or a fourfold rise
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	== Management ==		== Management ==

	* Doxycycline 100 mg po bid		* Doxycycline 100 mg po bid