https://idwiki.org/index.php?action=history&feed=atom&title=Anaphylaxis
Anaphylaxis - Revision history
2026-05-12T23:31:22Z
Revision history for this page on the wiki
MediaWiki 1.43.8
https://idwiki.org/index.php?title=Anaphylaxis&diff=5074&oldid=prev
Aidan: Text replacement - "Clinical Presentation" to "Clinical Manifestations"
2020-07-20T01:10:06Z
<p>Text replacement - "Clinical Presentation" to "Clinical Manifestations"</p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="en">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 01:10, 20 July 2020</td>
</tr><tr>
<td colspan="2" class="diff-lineno">Line 23:</td>
<td colspan="2" class="diff-lineno">Line 23:</td>
</tr>
<tr>
<td class="diff-marker"></td>
<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>** Hypotension after exposure to a '''known allergen'''</div></td>
<td class="diff-marker"></td>
<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>** Hypotension after exposure to a '''known allergen'''</div></td>
</tr>
<tr>
<td class="diff-marker"></td>
<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td>
<td class="diff-marker"></td>
<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td>
</tr>
<tr>
<td class="diff-marker" data-marker="−"></td>
<td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>== Clinical <del style="font-weight: bold; text-decoration: none;">Presentation</del> ==</div></td>
<td class="diff-marker" data-marker="+"></td>
<td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>== Clinical <ins style="font-weight: bold; text-decoration: none;">Manifestations</ins> ==</div></td>
</tr>
<tr>
<td class="diff-marker"></td>
<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td>
<td class="diff-marker"></td>
<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td>
</tr>
<tr>
<td class="diff-marker"></td>
<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* History</div></td>
<td class="diff-marker"></td>
<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* History</div></td>
</tr>
<!-- diff cache key site7_mediawiki:diff:1.41:old-4085:rev-5074:wikidiff2=table:1.13.0:bc2a06be -->
</table>
Aidan
https://idwiki.org/index.php?title=Anaphylaxis&diff=4085&oldid=prev
Maintenance script: Imported from text file
2020-07-04T01:17:22Z
<p>Imported from text file</p>
<p><b>New page</b></p><div>== Definition ==<br />
<br />
* Life-threatening IgE-mediated allergic reaction affecting multiple organ systems<br />
<br />
== Pathophysiology ==<br />
<br />
* Allergen epitopes interacti with IgE on mast cells of basophils<br />
* This causes degranulation and the release of tryptase, TNF-alpha, and histamine<br />
<br />
== NIAID/FAAN Criteria ==<br />
<br />
* Any one of the three following criteria:<br />
** Acute onset of illness with involvement of (with or '''without an allergen'''):<br />
*** Skin/mucosa (pruritus, flushing, hives, angioedema)<br />
*** And either:<br />
**** Respiratory compromise (dyspnea, decreased PEF, stridor, hypoxemia)<br />
**** Hypotension or end-organ dysfunction (collapse, syncope, incontinence)<br />
** Two or more of the following occurring after a '''likely allergen''' exposure:<br />
*** Skin/mucosa (pruritus, flushing, hives, angioedema)<br />
*** Respiratory compromise (dyspnea, decreased PEF, stridor, hypoxemia)<br />
*** Hypotension or end-organ dysfunction (collapse, syncope, incontinence)<br />
*** Persistent GI symptoms (vomiting, crampy abdo pain, diarrhea)<br />
** Hypotension after exposure to a '''known allergen'''<br />
<br />
== Clinical Presentation ==<br />
<br />
* History<br />
** Co-factors that augment anaphylaxis:<br />
*** Exercise<br />
*** NSAIDs<br />
*** Alcohol<br />
*** URTI<br />
*** Premenstruation<br />
* Signs &amp; Symptoms<br />
<br />
== Investigations ==<br />
<br />
* Serum tryptase<br />
<br />
== Management ==<br />
<br />
=== Acute ===<br />
<br />
* IV, O2, monitor<br />
* '''Remove allergen''', including any IVs that might be running allergen<br />
* Intramuscular epinephrine 1:1000 0.01mg/kg (max 0.5mg) IM q5-15min for 3 doses, if needed<br />
* Large-volume IV fluids<br />
* Add vasopressors or glucagon if persistent hypotension<br />
** Start epinephrine infusion 2-10mcg/kg/min<br />
** Reverse beta-blocker if necessary with 1-5mg IV glucagon<br />
* Place supine (or left decubitus if pregnant)<br />
* Supplemental oxygen; consider airway management<br />
* Consider salbutamol for bronchospasm<br />
<br />
=== Subacute ===<br />
<br />
* Ranitidine 50mg IV; diphenhydramine 25-50mg IV<br />
* There is a risk of '''biphasic reaction 8-72 hours''' after resolution<br />
** Methylprednisolone 125mg IV<br />
* Observe for 4-8 hours<br />
* Prescribe epinephrine autoinjectors<br />
* Arrange follow-up with allergist<br />
<br />
=== Chronic ===<br />
<br />
* Epi-Pen<br />
* Desensitization, when appropriate<br />
<br />
[[Category:Critical care]]<br />
[[Category:Immunology]]</div>
Maintenance script