https://idwiki.org/index.php?action=history&feed=atom&title=Amyloidosis 2026-05-12T23:38:38Z Revision history for this page on the wiki MediaWiki 1.43.8 https://idwiki.org/index.php?title=Amyloidosis&diff=4084&oldid=prev 2020-07-04T01:17:22Z

<p>Imported from text file</p> <p><b>New page</b></p><div>== Definition ==<br /> <br /> * A variety of diseases all characterized by tissue deposition of proteins<br /> <br /> == Types ==<br /> <br /> === AL amyloidosis ===<br /> <br /> * Immunoglobulin light chain deposition disease related to plasma cell dyscrasias<br /> * Can be primary or secondary to multiple myeloma (or, rarely, Waldentröm macroglobulinemia)<br /> <br /> === AA amyloidosis ===<br /> <br /> * Often secondary to RA, spondyloarthropathy, IBD, chronic infections, heredofamilial periodic fever syndromes, or neoplasms<br /> * Most commonly involvs the kidney, though heart and other oragns may also be involved<br /> <br /> === Dialysis-related ===<br /> <br /> * Deposition of beta-2 microglobin fibrils that accumulate in end-stage renal disease while on dialysis<br /> * Predominantly affects muskuloskeletal structurs<br /> ** Scapulohumeral joint<br /> ** Rotator cuff most<br /> ** Carpal tunnel<br /> <br /> === Heritable myoidoses ===<br /> <br /> * Many mutations can lead to this<br /> <br /> === Age-related senile systemic amyloidosis (SSA) ===<br /> <br /> * Deposition of wild-type transthyretin<br /> * Often involves heart, causing age-related cardiomegaly and heart failure<br /> ** Common on autopsy, often clinically insignificant<br /> * Renal involvement is rare, but can cause carpal tunnel syndrome<br /> <br /> === Organ-specific amyloidosis ===<br /> <br /> * Alzheimer disease<br /> * Macular, nodular, and lichen cutaneous amyloidosis<br /> * Bladder amyloidosis causing dysuria and severe hemorrhage<br /> * Many others<br /> <br /> [[Category:Neurology]]<br /> [[Category:Rheumatology]]</div>

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