Amphotericin B - Revision history

Aidan at 21:44, 3 February 2026

2026-02-03T21:44:06Z

Aidan at 13:01, 22 October 2024

2024-10-22T13:01:10Z

← Older revision		Revision as of 13:01, 22 October 2024
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	\|[[Aspergillus flavus]]		\|[[Aspergillus flavus]]
	\|4		\|4
	\|		\|—
			\| colspan="2" rowspan="6" \|
	\|
	\|		\|—
			\| colspan="4" rowspan="6" \|
	\|
	\|
	\|
	\|
	\|
	\|-		\|-
	\|[[Aspergillus fumigatus]]		\|[[Aspergillus fumigatus]]
	\|2		\|1
			\|≤1
	\|
	\|		\|>1
	\|
	\|
	\|
	\|
	\|
	\|
	\|-		\|-
	\|[[Aspergillus]]		\|[[Aspergillus nidulans]]
	\|2		\|4
	\|		\|—
	\|		\|—
	\|
	\|
	\|
	\|
	\|
	\|
	\|-		\|-
	\|[[Aspergillus]]		\|[[Aspergillus niger]]
	\|4		\|0.5
			\|≤1
	\|
	\|		\|>1
	\|		\|-
			\|[[Aspergillus terreus]]
	\|
	\|		\|8
	\|		\|—
	\|		\|—
	\|
	\|-		\|-
	\|[[Aspergillus versicolor]]		\|[[Aspergillus versicolor]]
	\|2		\|2
	\|		\|—
	\|		\|—
	\|
	\|
	\|
	\|
	\|
	\|
	\|}		\|}

Aidan at 12:00, 9 November 2022

2022-11-09T12:00:09Z

← Older revision		Revision as of 12:00, 9 November 2022
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	*Binds to ergosterol in fungal cell membrane and creates pores that cause leakage of monovalent ions		*Binds to ergosterol in fungal cell membrane and creates pores that cause leakage of monovalent ions
	*Causes renal dysfunction, among other things		*Causes renal dysfunction, among other things

			=== Spectrum of Activity ===

			* Very broad antifungal
			* However, there is often non-susceptibility with [[Candida auris]], [[Candida lusitaniae]], [[Sporothrix]], [[Fusarium]], [[Scedosporium]], and [[Aspergillus terreus]]

	===Clinical Breakpoints===		===Clinical Breakpoints===

Aidan: Text replacement - " species]]" to "]]"

2022-02-01T11:36:10Z

Text replacement - " species]]" to "]]"

← Older revision		Revision as of 11:36, 1 February 2022
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	\|		\|
	\|-		\|-
	\|[[Aspergillus ~~species~~]]		\|[[Aspergillus]]
	\|2		\|2
	\|		\|
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	\|		\|
	\|-		\|-
	\|[[Aspergillus ~~species~~]]		\|[[Aspergillus]]
	\|4		\|4
	\|		\|

Aidan at 14:04, 9 April 2021

2021-04-09T14:04:15Z

@@ Line 1: / Line 1: @@
 *Last choice of antifungal due to side effect profile, but effective
 *Binds to ergosterol in fungal cell membrane and creates pores that cause leakage of monovalent ions
 *Causes renal dysfunction, among other things
-== Clinical Breakpoints ==
+===Clinical Breakpoints===
 {| class="wikitable"
 ! rowspan="2" |Species
@@ Line 184: / Line 186: @@
+|
 |}
 [[Category:Polyenes]]

Aidan at 01:18, 20 January 2021

2021-01-20T01:18:11Z

Show changes

Aidan at 11:01, 26 August 2020

2020-08-26T11:01:40Z

← Older revision		Revision as of 11:01, 26 August 2020
Line 3:		Line 3:
	*Causes renal dysfunction, among other things		*Causes renal dysfunction, among other things

	[[Category:~~Antifungals~~]]		[[Category:Polyenes]]

Aidan at 15:37, 14 August 2020

2020-08-14T15:37:19Z

← Older revision		Revision as of 15:37, 14 August 2020
Line 1:		Line 1:
	* Last choice of antifungal due to side effect profile, but effective		*Last choice of antifungal due to side effect profile, but effective
			*Binds to ergosterol in fungal cell membrane and creates pores that cause leakage of monovalent ions
	* Causes renal dysfunction, among other things		*Causes renal dysfunction, among other things

	[[Category:Antifungals]]		[[Category:Antifungals]]

Aidan: /* Amphotericin B */

2019-08-13T12:04:39Z

Amphotericin B

← Older revision		Revision as of 12:04, 13 August 2019
Line 1:		Line 1:
	= Amphotericin B =

	* Last choice of antifungal due to side effect profile, but effective		* Last choice of antifungal due to side effect profile, but effective
	* Causes renal dysfunction, among other things		* Causes renal dysfunction, among other things

			[[Category:Antifungals]]

Aidan: Aidan moved page Amphotericin to Amphotericin B without leaving a redirect

2019-08-13T12:04:23Z

Aidan moved page Amphotericin to Amphotericin B without leaving a redirect

← Older revision	Revision as of 12:04, 13 August 2019
(No difference)

← Older revision		Revision as of 21:44, 3 February 2026
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	* Usual dose: 0.3 to 1.5 mg/kg IV daily		* Usual dose: 0.3 to 1.5 mg/kg IV daily
	* Disseminated aspergillosis: 0.6 to 0.7 mg/kg IV daily for 3 to 6 months		* Disseminated [[aspergillosis]]: 0.6 to 0.7 mg/kg IV daily for 3 to 6 months
	* Blastomycosis: 0.7 to 1 mg/kg IV daily for 1 to 2 weeks followed by [[itraconazole]]		* [[Blastomycosis]]: 0.7 to 1 mg/kg IV daily for 1 to 2 weeks followed by [[itraconazole]]
	* Candidiasis		* [[Candidiasis]]
	** CNS infection: 0.01 to 0.5 mg/2mL in D5W intraventricularly		** CNS infection: 0.01 to 0.5 mg/2mL in D5W intraventricularly
	** Endophthalmitis: 5 to 10 mcg/0.1 mL intravitreally		** Endophthalmitis: 5 to 10 mcg/0.1 mL intravitreally
	** Esophageal: 0.3 to 0.7 mg/kg IV daily		** [[Esophageal candidiasis\|Esophageal]]: 0.3 to 0.7 mg/kg IV daily
	** Invasive: 0.5 to 0.7 mg/kg IV daily; consider higher dosing up to 1 mg/kg for [[Candida glabrata]] or [[Candida krusei]]		** Invasive: 0.5 to 0.7 mg/kg IV daily; consider higher dosing up to 1 mg/kg for [[Candida glabrata]] or [[Candida krusei]]
	** Oropharyngeal: 100 mg suspended in 1 mL 4 times daily		** Oropharyngeal: 100 mg suspended in 1 mL 4 times daily
	** Urinary tract infection:		** [[Fungal urinary tract infection\|Urinary tract infection]]:
	*** Cystitis: 0.3 to 0.6 mg/kg IV daily for 1 to 7 days		*** Cystitis: 0.3 to 0.6 mg/kg IV daily for 1 to 7 days
	*** Pyelonephritis: 0.3 to 0.6 mg/kg IV daily for 1 to 7 days, with or without [[flucytosine]]		*** Pyelonephritis: 0.3 to 0.6 mg/kg IV daily for 1 to 7 days, with or without [[flucytosine]]
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	* Usual dose: 3 to 6 mg/kg IV daily		* Usual dose: 3 to 6 mg/kg IV daily
	* Aspergillosis: 3 to 5 mg/kg IV daily; up to 7.5 mg/kg for CNS infections		* [[Aspergillosis]]: 3 to 5 mg/kg IV daily; up to 7.5 mg/kg for CNS infections
	* Candidiasis:		* [[Candidiasis]]:
	** Candidemia: 3 to 5 mg/kg IV daily		** [[Candidemia]]: 3 to 5 mg/kg IV daily
	** CNS: 5 mg/kg IV daily		** CNS: 5 mg/kg IV daily
	** Hepatosplenic: 3 to 5 mg/kg IV daily		** [[Hepatosplenic candidiasis\|Hepatosplenic]]: 3 to 5 mg/kg IV daily
	** Invasive: 3 to 5 mg/kg IV daily		** Invasive: 3 to 5 mg/kg IV daily
	** Endocarditis: 3 to 5 mg/kg IV daily +/- [[flucytosine]]		** [[Fungal endocarditis\|Endocarditis]]: 3 to 5 mg/kg IV daily +/- [[flucytosine]]
	** Endophthalmitis: 3 to 5 mg/kg IV daily +/- [[flucytosine]]		** Endophthalmitis: 3 to 5 mg/kg IV daily +/- [[flucytosine]]
	** Osteomyelitis: 3 to 5 mg/kg IV daily		** Osteomyelitis: 3 to 5 mg/kg IV daily
	** Septic thrombophlebitis: 3 to 5 mg/kg IV daily		** Septic thrombophlebitis: 3 to 5 mg/kg IV daily
	* Coccidiomycosis:		* [[Coccidiomycosis]]:
	** Disseminated with HIV: 3 to 4 mg/kg IV daily with [[flucytosine]]		** Disseminated with HIV: 3 to 4 mg/kg IV daily with [[flucytosine]]
	** Meningitis with HIV: 3 to 4 mg/kg IV daily with [[flucytosine]]		** Meningitis with HIV: 3 to 4 mg/kg IV daily with [[flucytosine]]
	* Fungal sinusitis: 3 to 10 mg/kg IV daily		* Fungal sinusitis: 3 to 10 mg/kg IV daily
	* Histoplasmosis		* [[Histoplasmosis]]
	** Acute pulmonary: 3 to 5 mg/kg IV daily for 1 to 2 weeks, followed by [[itraconazole]]		** Acute pulmonary: 3 to 5 mg/kg IV daily for 1 to 2 weeks, followed by [[itraconazole]]
	** Disseminated: 3 mg/kg IV daily for 2 weeks, followed by [[itraconazole]]		** Disseminated: 3 mg/kg IV daily for 2 weeks, followed by [[itraconazole]]