https://idwiki.org/index.php?action=history&feed=atom&title=Alzheimer_disease 2026-05-13T00:53:40Z Revision history for this page on the wiki MediaWiki 1.43.8 https://idwiki.org/index.php?title=Alzheimer_disease&diff=4976&oldid=prev 2020-07-16T07:14:40Z

<p>Text replacement - &quot;Clinical Presentation&quot; to &quot;Clinical Manifestations&quot;</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 07:14, 16 July 2020</td> </tr><tr> <td colspan="2" class="diff-lineno">Line 17:</td> <td colspan="2" class="diff-lineno">Line 17:</td> </tr> <tr> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Gene mutations: APP, PS-1, PS-2, and Apo epsilon-4</div></td> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Gene mutations: APP, PS-1, PS-2, and Apo epsilon-4</div></td> </tr> <tr> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td> </tr> <tr> <td class="diff-marker" data-marker="−"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>== Clinical <del style="font-weight: bold; text-decoration: none;">Presentation</del> ==</div></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>== Clinical <ins style="font-weight: bold; text-decoration: none;">Manifestations</ins> ==</div></td> </tr> <tr> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td> </tr> <tr> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* History</div></td> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* History</div></td> </tr> <!-- diff cache key site7_mediawiki:diff:1.41:old-4081:rev-4976:wikidiff2=table:1.13.0:bc2a06be --> </table>

Aidan https://idwiki.org/index.php?title=Alzheimer_disease&diff=4081&oldid=prev 2020-07-04T01:17:22Z

<p>Imported from text file</p> <p><b>New page</b></p><div>== Pathophysiology ==<br /> <br /> * Build-up of beta amyloid plaques with neurofibrillary tangles<br /> * Degeneration of the transentorhinal region, followed by hippocampus then lateral and posterior temporal and parietal neocortex<br /> <br /> == Differential Diagnosis ==<br /> <br /> * See [[Dementia.md|Dementia]]<br /> <br /> == Epidemiology ==<br /> <br /> * Most prevalent dementia syndrome<br /> <br /> == Risk Factors ==<br /> <br /> * Age<br /> * Gene mutations: APP, PS-1, PS-2, and Apo epsilon-4<br /> <br /> == Clinical Presentation ==<br /> <br /> * History<br /> ** Typically begins with memory loss<br /> ** Later, aphasia and navigational problems<br /> * Signs &amp;amp; Symptoms<br /> <br /> == Management ==<br /> <br /> === Symptomatic Treatments ===<br /> <br /> * Cholinesterase inhibitors for AD with stroke, and as an option for Parkinson disease dementia<br /> ** Not indicated in vascular dementia<br /> ** No specific preferred cholinesterase inhibitor<br /> ** Modest improvements in cognition but does not delay nursing home<br /> ** Side effects include bradycardia, syncope, GI intolerance, urinary incontinence, and abnormal dreams<br /> *** NMS and rhabdomyolysis are rare but reported<br /> * Combination with memantine appears safe<br /> ** Can either add memantine to cholinesterase inhibitor, or replace it<br /> * Trial of antidepressent can be considered in patients with depression, severe dysthymia, or emotional lability<br /> * Antipsychotics should be reserved for cases where the patient&#039;s agitated causes a risk of harm to themselves or others<br /> <br /> === Discontinuation of Acetylcholinesterase Inhibitors ===<br /> <br /> * May worsen cognition, but should be considered if there are adverse side effects, or the dementia has progressed past the point where they would be helpful<br /> * If stopped for non-effectiveness, they should be tapered before stopping, then monitored for cognitive decline<br /> <br /> == Further Reading ==<br /> <br /> * [http://dx.doi.org/10.5770/cgj.15.49 Canadian Dementia Guidelines CCCDTD4 2012]<br /> <br /> [[Category:Neurology]]<br /> [[Category:Geriatrics]]</div>

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