https://idwiki.org/index.php?action=history&feed=atom&title=Allergic_bronchopulmonary_aspergillosis 2026-04-29T02:08:43Z Revision history for this page on the wiki MediaWiki 1.43.8 https://idwiki.org/index.php?title=Allergic_bronchopulmonary_aspergillosis&diff=7825&oldid=prev 2021-04-30T14:12:21Z

<p>Created page with &quot;== Background == * Colonization of the airways prompting an allergic reaction that worsens <a href="/Asthma" title="Asthma">asthma</a> * Caused by a Th2 response to &#039;&#039;Aspergillus&#039;&#039;, usually in patients with...&quot;</p> <p><b>New page</b></p><div>== Background ==<br /> <br /> * Colonization of the airways prompting an allergic reaction that worsens [[asthma]]<br /> * Caused by a Th2 response to &#039;&#039;Aspergillus&#039;&#039;, usually in patients with [[asthma]] or [[cystic fibrosis]]<br /> <br /> == Clinical Manifestations ==<br /> <br /> * Characterized by poorly-controlled asthma or pneumonia, mucoid impaction, persistent eosinophilia<br /> * The course is characterized by exacerbations and remissions, leading to eventual pulmonary fibrosis and chronic pulmonary aspergillosis<br /> * The most important diagnostic criterion is elevated &#039;&#039;Aspergillus&#039;&#039;-specific IgE<br /> * Supportive criteria include elevated total IgE &gt;417 IU/mL, &#039;&#039;Aspergillus&#039;&#039;-specific IgG, &#039;&#039;Aspergillus&#039;&#039; serum precipitins, positive skin prick test for &#039;&#039;Aspergillus&#039;&#039;, or eosinophilia<br /> * Other findings include &#039;&#039;Aspergillus&#039;&#039; on sputum culture, brown mucous plugs with dead eosinophils, and CXR or CT showing bronchiectasis<br /> <br /> == Management ==<br /> <br /> *Indications for treatment<br /> **Diagnose with &#039;&#039;Aspergillus&#039;&#039;-IgE<br /> **If ongoing symptoms despite appropriate management of asthma (including oral steroids), treat with [[itraconazole]]<br /> **If CF patient has frequent exacerbations or falling FEV1, treat with itraconazole<br /> *[[Itraconazole]] 200 mg/day for 16 weeks, which decreases steroid use and increases patient function<br /> <br /> &lt;br /&gt;<br /> [[Category:Hyaline molds]]<br /> [[Category:Respiratory infections]]</div>

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