Adverse drug reaction - Revision history

Aidan at 14:27, 27 March 2024

2024-03-27T14:27:00Z

← Older revision		Revision as of 14:27, 27 March 2024
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	*Antimicrobials are one of the largest causes of adverse drug reactions		*Antimicrobials are one of the largest causes of adverse drug reactions

	===Immune-~~mediated~~ Hypersensitivity Reactions===		===Immune-Mediated Hypersensitivity Reactions===

	* See also [[Hypersensitivity reaction]]		* See also [[Hypersensitivity reaction]]

	{\| class="wikitable"		{\| class="wikitable"
	!Type		! colspan="2" \|Type
	!Description		!Description
	!Examples		!Examples
	\|-		\|-
			\| colspan="2" \|I
	\|I
	\|immediate IgE-mediated reaction		\|immediate IgE-mediated reaction
	\|[[anaphylaxis]]		\|[[anaphylaxis]]
	\|-		\|-
			\| colspan="2" \|II
	\|II
	\|antibody-mediated cytotoxic reaction		\|antibody-mediated cytotoxic reaction
	\|[[hemolytic anemia]] from [[penicillin]]		\|[[hemolytic anemia]] from [[penicillin]]
	\|-		\|-
	\|III		\| colspan="2" \|III
	\|immune complex-mediated reaction		\|immune complex-mediated reaction
	\|[[serum sickness]] from cephalosporins		\|[[serum sickness]] from cephalosporins
	\|-		\|-
			\| rowspan="5" \|IV
	\|IV		\|IV
	\|delayed cell-mediated reaction		\|delayed cell-mediated reaction
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	\|}		\|}

	===Non-~~immune~~-~~mediated~~ Hypersensitivity Reactions===		===Non-Immune-Mediated Hypersensitivity Reactions===
	{\| class="wikitable"		{\| class="wikitable"
	!Type		!Type
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	**Risk factors: elderly, concomitant steroids, renal failure, diabetes, history of MSK disorders, male sex		**Risk factors: elderly, concomitant steroids, renal failure, diabetes, history of MSK disorders, male sex
	***Steroids cause chondrocyte apoptosis		***Steroids cause chondrocyte apoptosis
	**

	===Beta Lactams===		===Beta Lactams===
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	**Inhibits GABA release		**Inhibits GABA release
	**More common with renal failure, elderly, high doses		**More common with renal failure, elderly, high doses
	**1 to 10 days after starting the ~~abx~~		**1 to 10 days after starting the antibiotics
	**Resolves 2 to 7 days after stopping		**Resolves 2 to 7 days after stopping

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	*May be acute or chronic (9 days vs months or years)		*May be acute or chronic (9 days vs months or years)
	*No fevers, eosinophilia, or pleural effusions		*No fevers, eosinophilia, or pleural effusions
	*Risk ~~factosr~~ include CKD, high prolonged doses, older age, female sex		*Risk factors include CKD, high prolonged doses, older age, female sex
	*Mechanism is toxic metabolites induce injury of lung microsomes with oxidative stress		*Mechanism is toxic metabolites induce injury of lung microsomes with oxidative stress
	*Acute: Type I or III hypersensitivity, resolves with discontinuation		*Acute: Type I or III hypersensitivity, resolves with discontinuation
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	===Drug Fevers===		===Drug Fevers===

	*Most commonly beta lactams and Septra		*Most commonly beta lactams and [[Septra]]
	*Caused by byproducts of hepatically created metabolites?		*Caused by byproducts of hepatically created metabolites?
	*Can be high fevers; relative bradycardia, patient appears well, no rigors, maybe liver enzymes up, normal eosinophils, often left shift of elevated WBC		*Can be high fevers; relative bradycardia, patient appears well, no rigors, maybe liver enzymes up, normal eosinophils, often left shift of elevated WBC
	*Usually takes 5 to 10 days		*Usually takes 5 to 10 days
	*Normalizes ~~withing~~ 72 hours of discontinuation		*Normalizes within 72 hours of discontinuation

	===QT Prolongation===		===QT Prolongation===
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	*Antibiotics are 25% of drug-induced diarrhea		*Antibiotics are 25% of drug-induced diarrhea
	*Appears within days, resolves after discontinuing		*Appears within days, resolves after discontinuing
	*Mechanism includes ~~diruption~~ of normal gut flora, which can also cause impaired fermentation		*Mechanism includes disruption of normal gut flora, which can also cause impaired fermentation
	*Highest risk includes macrolides (promotility), ~~fluroquinolones~~, amoxicillin/~~clavulatate~~		*Highest risk includes [[macrolides]] (promotility), [[fluoroquinolones]], [[Amoxicillin-clavulanic acid\|amoxicillin/clavulanic acid]]

	===Acute Tubular Necrosis===		===Acute Tubular Necrosis===
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	*Typically beta lactams		*Typically beta lactams
	*Oliguria, malaise, ~~anorexisa~~, nausea/vomiting		*Oliguria, malaise, anorexia, nausea/vomiting
	*Rash, fever, eosinophils, arthralgias		*Rash, fever, eosinophils, arthralgias
	*T-cell mediated hypersensitivity		*T-cell mediated hypersensitivity
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	===Rash===		===Rash===

	*Amipicillin is the ~~msot~~ common penicillin, more ~~commoly~~ in women, especially with viral infections		*Amipicillin is the most common penicillin, more commonly in women, especially with viral infections
	*Maculopapular rash		*Maculopapular rash
	**Most common		**Most common
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	**Start to recover after 3 to 4 days of discontinuation if it was marrow suppression		**Start to recover after 3 to 4 days of discontinuation if it was marrow suppression
	**Longer if immune-mediated reaction		**Longer if immune-mediated reaction
	*Linezolid, vancomycin,		*[[Linezolid]], [[vancomycin]]

	===Aplastic ~~anemia~~===		===Aplastic Anemia===

	*From Septra		*From [[Septra]]

	===Daptomycin===		===Daptomycin===

Aidan at 13:30, 14 September 2023

2023-09-14T13:30:29Z

← Older revision		Revision as of 13:30, 14 September 2023
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	* Any noxious and unintended response to a drug or natural health product that occurs at a normal dose		* Any noxious and unintended response to a drug or natural health product that occurs at a normal dose
			** Causality is attributed to the treatment based on clinical judgment as related, not related, or unknown; if at least a possible relationship exists, it is considered an adverse reaction
	* A '''serious adverse drug reaction''' is one that requires inpatient hospitalization (or prolongation of existing hospitalization), causes congenital malformation, results in persistent or significant disability or incapacity, is life threatening, or results in death		* A '''serious adverse drug reaction''' is one that requires inpatient hospitalization (or prolongation of existing hospitalization), causes congenital malformation, results in persistent or significant disability or incapacity, is life threatening, or results in death
	** Also known as a serious adverse event		** Also known as a serious adverse event

Aidan at 13:27, 14 September 2023

2023-09-14T13:27:39Z

← Older revision		Revision as of 13:27, 14 September 2023
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	* Any noxious and unintended response to a drug or natural health product that occurs at a normal dose		* Any noxious and unintended response to a drug or natural health product that occurs at a normal dose
			* A '''serious adverse drug reaction''' is one that requires inpatient hospitalization (or prolongation of existing hospitalization), causes congenital malformation, results in persistent or significant disability or incapacity, is life threatening, or results in death
			** Also known as a serious adverse event
			* A '''serious unexpected adverse drug reaction''' is one that is not identified in the brochure or label of the drug or natural health product
			** Also known as a suspected unexpected serious adverse reaction

	===Risk Factors===		===Risk Factors===
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	[[Category:Medications]]		[[Category:Medications]]
			[[Category:Research]]

Aidan: added definition

2023-09-14T13:22:00Z

added definition

← Older revision		Revision as of 13:22, 14 September 2023
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	==Background==		==Background==

			* Any noxious and unintended response to a drug or natural health product that occurs at a normal dose

	===Risk Factors===		===Risk Factors===

Aidan: Aidan moved page Adverse drug reactions to Adverse drug reaction without leaving a redirect

2023-09-14T13:19:08Z

Aidan moved page Adverse drug reactions to Adverse drug reaction without leaving a redirect

← Older revision		Revision as of 13:19, 14 September 2023
(No difference)

Aidan: /* Immune-mediated Hypersensitivity Reactions */

2021-02-25T17:55:18Z

Immune-mediated Hypersensitivity Reactions

← Older revision		Revision as of 17:55, 25 February 2021
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	== Background ==		==Background==

	===Risk Factors===		===Risk Factors===
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	===Immune-mediated Hypersensitivity Reactions===		===Immune-mediated Hypersensitivity Reactions===

			* See also [[Hypersensitivity reaction]]

	{\| class="wikitable"		{\| class="wikitable"
	!Type		!Type

Aidan at 17:29, 20 August 2020

2020-08-20T17:29:57Z

← Older revision		Revision as of 17:29, 20 August 2020
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	}}		}}

	[[Category:~~Antimicrobials~~]]		[[Category:Medications]]

Aidan: Aidan moved page Adverse antimicrobial reactions to Adverse drug reactions

2020-08-05T00:45:32Z

Aidan moved page Adverse antimicrobial reactions to Adverse drug reactions

← Older revision		Revision as of 00:45, 5 August 2020
(No difference)

Aidan: /* List of Adverse Drug Reactions */

2020-08-04T02:50:20Z

List of Adverse Drug Reactions

← Older revision		Revision as of 02:50, 4 August 2020
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	{{#ask:		{{#ask:
	[[Category:Antivirals]]		[[Category:Antivirals]]
			\|?Adverse drug reaction
			}}
			===Antiparasitics===
			{{#ask:
			[[Category:Antiparasitics]]
	\|?Adverse drug reaction		\|?Adverse drug reaction
	}}		}}

Aidan: /* Background */

2020-07-29T23:53:53Z

Background

@@ Line 12: / Line 12: @@
 *Antimicrobials are one of the largest causes of adverse drug reactions
-===Classification of Non-Immune Hypersensitivity Reactions===
+===Immune-mediated Hypersensitivity Reactions===
 {| class="wikitable"
 !Type
@@ Line 71: / Line 48: @@
 |IVd
 |delayed T-cell-mediated neutrophilic reaction
+|
 |}