Aidan: Created page with "== Differential Diagnosis == * Infection: Viral: HIV, herpesviruses, measles, rubella, viral hepatitis, parvovirus B19 Bacterial: borreliosis, brucellosis, yersiniosis, tuberculosis, syphilis, Mycoplasma pneumoniae, Whipple disease ** Other: toxoplasmosis, infective endocarditis, sepsis * Malignancies: Multicentric Castleman disease, angioimmunoblastic lymphadenopathy, Hodgkin lymphoma, ..."

2026-02-04T18:28:03Z

Created page with "== Differential Diagnosis == * Infection: ** Viral: HIV, herpesviruses, measles, rubella, viral hepatitis, parvovirus B19 ** Bacterial: borreliosis, brucellosis, yersiniosis, tuberculosis, syphilis, Mycoplasma pneumoniae, Whipple disease ** Other: toxoplasmosis, infective endocarditis, sepsis * Malignancies: Multicentric Castleman disease, angioimmunoblastic lymphadenopathy, Hodgkin lymphoma, ..."

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== Differential Diagnosis ==

* Infection:
** Viral: [[HIV]], [[herpesviruses]], [[measles]], [[rubella]], [[viral hepatitis]], [[parvovirus B19]]
** Bacterial: [[borreliosis]], [[brucellosis]], [[yersiniosis]], [[tuberculosis]], [[syphilis]], [[Mycoplasma pneumoniae]], [[Whipple disease]]
** Other: [[toxoplasmosis]], [[infective endocarditis]], [[sepsis]]
* Malignancies: [[Multicentric Castleman disease]], [[angioimmunoblastic lymphadenopathy]], [[Hodgkin lymphoma]], [[non-Hodgkin lymphoma]], solid-organ maligancies, [[melanoma]], [[angiosarcoma]], [[myeloproliferative disorder]], [[paraneoplastic syndrome]]
* Other autoimmune disorders: [[idiopathic inflammatory myopathy]], seronegative [[rheumatoid arthritis]], [[reactive arthritis]], [[polyarteritis nodosa]], [[familial Mediterranean fever]], [[Mevalonate kinase deficiency]], [[polymyositis]], [[dermatomyositis]], [[Sweet syndrome]], [[sarcoidosis]], [[Schnitzler syndrome]], [[systemic lupus erythematosus]]
* [[DRESS]]
* Others: [[hemophagocytic lymphohistiocytosis]], [[neutrophilic dermatosis]], [[Kikuchi-Fujimoto disease]]

== Diagnostic Criteria (Yamaguchi) ==

* Major criteria:
** Fever ≥ 39 degrees C (102.2 degrees F) for ≥ 1 week
** Arthralgia or arthritis for ≥ 2 weeks
** Typical evanescent rash
** Leukocytosis (white blood cells > 10,000/mm<sup>3</sup>) with ≥ 80% granulocytes
* Minor criteria:
** Sore throat
** Lymphadenopathy
** Hepatomegaly or splenomegaly
** Abnormal liver function tests
** Absence of rheumatoid factor and antinuclear antibody
* Positive with ≥ 5 criteria including ≥ 2 major criteria

* Exclusion criteria include:
** Infection
** Malignancy, particularly malignant lymphoma
** Other rheumatic disease, particularly systemic vasculitides

[[Category:Rheumatology]]

Adult-onset Still disease - Revision history