Γ-glutamyltransferase - Revision history

Aidan at 13:58, 10 November 2021

2021-11-10T13:58:36Z

← Older revision		Revision as of 13:58, 10 November 2021
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	[[Category:Investigations]]		[[Category:Investigations]]
	{{DEFAULTSORT:gamma-glutamyltransferase}}		{{DEFAULTSORT:gamma-glutamyltransferase}}

			== Background ==

			* Liver enzyme in microsomes that catalyzes transfer of γ-glutamyl group from peptides to other amino acids

	== Interpretation ==		== Interpretation ==

	* About 90% sensitive for cholestasis (with ALP)		* About 90% sensitive for [[cholestasis]] (with ALP)
	**Often only rise after several days		**Often only rise after several days
	* Isolated elevation of GGT may be caused by enzyme induction from [[Alcohol use disorder\|alcohol]] or aromatic medications, without liver disease[[CiteRef::PMID10221307]]		* Isolated elevation of GGT may be caused by enzyme induction from [[Alcohol use disorder\|alcohol]] or aromatic medications, without liver disease[[CiteRef::PMID10221307]]
	** Aromatic medications include, commonly, [[phenobarbital]], [[phenytoin]], and others		** Aromatic medications include, commonly, [[phenobarbital]], [[phenytoin]], and others
	** Elevation is usually about twice the upper limit of normal		** Elevation is usually about twice the upper limit of normal
			*Can also see isolated elevations in [[COPD]], [[AKI]] or [[CKD]], and [[acute myocardial infarction]][[CiteRef::giannini2005li]]
			*May be elevated in [[NAFLD]] and [[hepatitis C]] and other liver or biliary diseases

2021-11-09T14:27:06Z

Interpretation

← Older revision		Revision as of 14:27, 9 November 2021
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	* About 90% sensitive for cholestasis (with ALP)		* About 90% sensitive for cholestasis (with ALP)
			**Often only rise after several days
	* Isolated elevation of GGT may be caused by enzyme induction from [[Alcohol use disorder\|alcohol]] or aromatic medications, without liver disease[[CiteRef::PMID10221307]]		* Isolated elevation of GGT may be caused by enzyme induction from [[Alcohol use disorder\|alcohol]] or aromatic medications, without liver disease[[CiteRef::PMID10221307]]
	** Aromatic medications include, commonly, [[phenobarbital]], [[phenytoin]], and others		** Aromatic medications include, commonly, [[phenobarbital]], [[phenytoin]], and others

2021-11-09T14:25:35Z

← Older revision		Revision as of 14:25, 9 November 2021
Line 3:		Line 3:
	[[Category:Investigations]]		[[Category:Investigations]]
	{{DEFAULTSORT:gamma-glutamyltransferase}}		{{DEFAULTSORT:gamma-glutamyltransferase}}

			== Interpretation ==

			* About 90% sensitive for cholestasis (with ALP)
			* Isolated elevation of GGT may be caused by enzyme induction from [[Alcohol use disorder\|alcohol]] or aromatic medications, without liver disease[[CiteRef::PMID10221307]]
			** Aromatic medications include, commonly, [[phenobarbital]], [[phenytoin]], and others
			** Elevation is usually about twice the upper limit of normal

2021-11-09T14:19:30Z

Created page with "{{DISPLAYTITLE:γ-glutamyltransferase}} Category:Investigations {{DEFAULTSORT:gamma-glutamyltransferase}}"

New page

{{DISPLAYTITLE:γ-glutamyltransferase}}

[[Category:Investigations]]
{{DEFAULTSORT:gamma-glutamyltransferase}}