Β-lactam resistance - Revision history

Aidan at 16:10, 2 April 2022

2022-04-02T16:10:33Z

← Older revision		Revision as of 16:10, 2 April 2022
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	*Porin channel mutations that reduce antibiotic influx		*Porin channel mutations that reduce antibiotic influx

	==β-lactamases==		===β-lactamases===

	*Also see [[Β-lactamases]]		*Also see [[Β-lactamases]]

	===Ambler Classification of ß-lactamases===		====Ambler Classification of ß-lactamases====

	*Based on amino acid sequences rather than function		*Based on amino acid sequences rather than function
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	\|}		\|}

	===Specific ß-lactamases===		====Specific ß-lactamases====

	*TEM-1: most common β-lactamase in Gram-negative bacteria		*TEM-1: most common β-lactamase in Gram-negative bacteria
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	*OXA-48: most common carbapenemase in [[Acinetobacter]]		*OXA-48: most common carbapenemase in [[Acinetobacter]]

	==Efflux Pumps==		===Efflux Pumps===

	*Major cause of resistance in [[Pseudomonas aeruginosa]] and similar species		*Major cause of resistance in [[Pseudomonas aeruginosa]] and similar species
	*e.g. MexAB-OprM, which confers broad antimicrobial resistance including cephalosporins and some carbapanems		*e.g. MexAB-OprM, which confers broad antimicrobial resistance including cephalosporins and some carbapanems

	==Porin Loss==		===Porin Loss===

	*Most common cause of carbapenem resistance in [[Pseudomonas aeruginosa]]		*Most common cause of carbapenem resistance in [[Pseudomonas aeruginosa]]

2022-04-02T16:10:14Z

← Older revision		Revision as of 16:10, 2 April 2022
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	*Most common cause of carbapenem resistance in [[Pseudomonas aeruginosa]]		*Most common cause of carbapenem resistance in [[Pseudomonas aeruginosa]]

			== Management ==

			* See also [[Carbapenem-resistant organisms]]

	[[Category:Antibiotics]]		[[Category:Antibiotics]]

2022-03-12T23:19:41Z

← Older revision		Revision as of 23:19, 12 March 2022
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	*KPC: most common carbapenemase		*KPC: most common carbapenemase
	*NDM-1: broad-spectrum metallo-β-lactamase and carbapenemase		*NDM-1: broad-spectrum metallo-β-lactamase and carbapenemase
	*OXA-48: most common carbapenemase in [[Acinetobacter ~~species~~]]		*OXA-48: most common carbapenemase in [[Acinetobacter]]

	==Efflux Pumps==		==Efflux Pumps==

2020-09-12T12:40:00Z

β-lactamases

← Older revision		Revision as of 12:40, 12 September 2020
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	==β-lactamases==		==β-lactamases==

	* Also see [[Β-lactamases]]		*Also see [[Β-lactamases]]

	===Ambler Classification of ß-lactamases===		===Ambler Classification of ß-lactamases===
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	{\| class="wikitable"		{\| class="wikitable"
			!Class
	!Ambler
	!Binding Site		!Binding Site
	!Examples		!Examples

2020-09-12T12:37:36Z

β-lactamases

← Older revision		Revision as of 12:37, 12 September 2020
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	==β-lactamases==		==β-lactamases==

			* Also see [[Β-lactamases]]

	===Ambler Classification of ß-lactamases===		===Ambler Classification of ß-lactamases===
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	{\| class="wikitable"		{\| class="wikitable"
	\|+
	!Ambler		!Ambler
	!Binding Site		!Binding Site
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	===Specific ß-lactamases===		===Specific ß-lactamases===
	====NDM-1====

	*~~Broad~~-~~spectrum~~ ~~metallo-beta~~-lactamase ~~and~~ ~~carbapenemase~~		*TEM-1: most common β-lactamase in Gram-negative bacteria
			*KPC: most common carbapenemase
			*NDM-1: broad-spectrum metallo-β-lactamase and carbapenemase
			*OXA-48: most common carbapenemase in [[Acinetobacter species]]

	==Efflux Pumps==		==Efflux Pumps==

2020-09-03T11:06:33Z

Ambler Classification of ß-lactamases

2020-09-03T11:06:19Z

Ambler Classification of ß-lactamases

@@ Line 13: / Line 13: @@
 *Based on amino acid sequences rather than function
-*Classes A, C, and D are serine ß-lactamases
+*Classes A, C, and D are serine ß-lactamases, while class B are metallo-β-lactamases
 ===Specific ß-lactamases===
 ====NDM-1====
 *Broad-spectrum metallo-beta-lactamase and carbapenemase
 ==Efflux Pumps==

2020-08-02T12:14:08Z

← Older revision		Revision as of 12:14, 2 August 2020
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			{{DISPLAYTITLE:β-lactam resistance}}

	==Mechanisms==		==Mechanisms==

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	*Porin channel mutations that reduce antibiotic influx		*Porin channel mutations that reduce antibiotic influx

	== β-lactamases ==		==β-lactamases==

	===Ambler Classification of ß-lactamases===		===Ambler Classification of ß-lactamases===
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	*Can be treated empirically with [[ceftazidime-avibactam]] and [[aztreonam]] +/- [[colistin]]		*Can be treated empirically with [[ceftazidime-avibactam]] and [[aztreonam]] +/- [[colistin]]

	== Efflux Pumps ==		==Efflux Pumps==

	* Major cause of resistance in [[Pseudomonas aeruginosa]] and similar species		*Major cause of resistance in [[Pseudomonas aeruginosa]] and similar species
	* e.g. MexAB-OprM, which confers broad antimicrobial resistance including cephalosporins and some carbapanems		*e.g. MexAB-OprM, which confers broad antimicrobial resistance including cephalosporins and some carbapanems

	== Porin Loss ==		==Porin Loss==

	* Most common cause of carbapenem resistance in [[Pseudomonas aeruginosa]]		*Most common cause of carbapenem resistance in [[Pseudomonas aeruginosa]]

	[[Category:Antibiotics]]		[[Category:Antibiotics]]

2020-08-02T12:13:48Z

← Older revision	Revision as of 12:13, 2 August 2020
(No difference)

2020-08-02T12:13:26Z

@@ Line 1: / Line 1: @@
-== Mechanisms ==
+==Mechanisms==
-* ß-lactamase production: enzymatic breakdown of beta lactam antibiotic
+*ß-lactamase production: enzymatic breakdown of beta lactam antibiotic
-* Penicillin binding protein mutations (e.g. MRSA)
+*Penicillin binding protein mutations (e.g. MRSA)
-* Efflux pump mutations
+*Efflux pump mutations
-* Porin channel mutations that reduce antibiotic influx
+*Porin channel mutations that reduce antibiotic influx
-== Ambler Classification of ß-lactamases ==
+== β-lactamases ==
 [[Category:Antibiotics]]