View source for Lambert-Eaton myasthenic syndrome

== Background ==

* Paraneoplastic syndrome of weakness that is associated primarily with [[small cell lung cancer]], other solid cancers, or lymphoproliferative diseases
* Can be non-paraneoplastic (primary autoimmune)
* Pathophysiology is decreased acetylcholine release from the presynaptic nerves

== Clinical Manifestations ==

* Slowly progressive proximal muscle weakness without significant atrophy
* Legs often more than arms
* Recovery of lost DTRs with exercise or muscle activation (postexercise/postactivation facilitation)
* Autonomic dysfunction can include dry mouth, slow pupillary light reflex, and erectile dysfunction
* Can affect cranial nerves
* Can cause respiratory failure late in the course

[[Category:Respirology]]
[[Category:Oncology]]
[[Category:Neurology]]
[[Category:Paraneoplastic syndromes]]