View source for Acute hemolytic transfusion reaction

== Background ==

* Caused by:
** Incompatibles RBCs (ABO or other blood group)
** Incompatible plasma
* Occurs in 1 in 38,000 transfusion, usually due to clerical error causing patient to receive wrong blood
* Mortality about 10%

== Clinical Manifestations ==

* Fevers, chills, rigors, hemoglobinuria
** Fever may be only sign at presentation
* May have nausea, vomiting, pain at infusion site, flank pain, hypotension, [[AKI]], or [[DIC]]

== Management ==

* Stop transfusion and notify blood bank
* Send hemolysis workup with CBC, reticulocyte count, bilirubin, LDH, and haptoglobin
* Supportive care

[[Category:Hematology]]