View source for Acute febrile neutrophilic dermatosis

== Clinical Manifestations ==

* Sudden onset edematous, erythematous lesions (can be papules, nodules, or plaques)
* Fever, leukocytosis

== Diagnostic Criteria ==

=== Classical Sweet Syndrome ===

* Requires both major criteria and at least 2 minor criteria
* Major criteria:
** Abrupt onset of painful erythematous plaques or nodules
** Histopathologic evidence of a dense neutrophilic infiltrate without evidence of leukocytoclastic vasculitis
* Minor criteria:
** Fever greater than 38 Celsius
** Underlying hematologic or solid-organ malignancy, inflammatory disease, or pregnancy; or preceded by an upper respiratory or GI infection or vaccination
** Excellent response to systemic corticosteroids or potassium iodide
** Abnormal bloodwork at presentation, with at least 3 of: ESR >20 mm/h, elevated CRP, WBC >8, neutrophils >70%

=== Drug-Induced Sweet Syndrome ===

* Requires the presence of all five criteria
* Criteria:
** Abrupt onset of painful erythematous plaques or nodules
** Histopathologic evidence of a dense neutrophilic infiltrate without evidence of leukocytoclastic vasculitis
** Fever greater than 38 Celsius
** Temporal relationship between drug ingestion and clinical presentation, or temporally-related recurrence after oral challenge
** Temporal relationship between drug withdrawal or treatment with systemic corticosteroids and resolution of lesions

[[Category:Dermatology]]