View source for Nirmatrelvir-ritonavir

== Dosing ==

* COVID-19: Nirmatrelvir/ritonavir 300 mg/100 mg p.o. bid for 5 days, started within 5 days of symptom onset

=== Renal Dosing ===

* eGFR ≥60 mL/min: no adjustment
* eGFR 30-59 mL/min: 150 mg/100 mg p.o. bid
* eGFR <30 mL/min: 300 mg/100 mg load on day 1, followed by 150 mg/100 mg p.o daily for 4 more days
* Dialysis: 300 mg/100 mg load on day 1, followed by 150 mg/100 mg p.o daily for 4 more days, given after dialysis on dialysis days

=== Hepatic Dosing ===

* [[Child-Pugh classification|Child-Pugh]] class C: contraindicated

[[Category:Medications]]