Yellow fever vaccine-associated neurotropic disease
From IDWiki
Background
Risk Factors
- Extremes of age (children <6 months and adults >60-70 years)
Pathophysiology
- Meningoencephalitis (neurotropic disease) is caused by actual infection with the attenuated virue
- The other syndromes are caused by autoimmune phenomena
Clinical Manifestations
- Includes meningoencephalitis (neurotropic disease), acute disseminated encephalomyelitis, Guillain-Barré syndrome, and acute bulbar palsy
- Incubation period is 7 to 21 days (range 4 to 23 days)
- Rarely fatal
