Wiskott-Aldrich syndrome
From IDWiki
- Primary immunodeficiency
- X-linked recessive defect in the WASp gene located at xP 11.22-23
- Characterized by eczema, thrombocytopenia (causing bleeding), and immunodeficiency
- Immunodeficiency is characterized by recurrent infections with encapsulated organisms and recurrent sinopulmonary infections
- Myeloid cells have impaired phagocytosis and chemotaxis; also have issues with T cell and B cell dysfunction
