Indications for prophylaxis
| Patient
|
FHx of VTE?
|
Prophylaxis
|
| Prior VTE with provoked, transient risk factor
|
—
|
None
|
| Prior VTE either unprovoked or estrogen-related
|
—
|
Antepartum and postpartum
|
| Homozygous Factor V Leiden
|
Yes
|
Antepartum and postpartum
|
| Homozygous prothrombin gene mutation
|
Yes
|
Antipartum and postpartum
|
| Antithrombin-III deficiency
|
Yes
|
Antepartum and postpartum
|
| Other thrombophilia
|
Yes
|
Postpartum only
|
| Homozygous Factor V Leiden
|
No
|
Postpartum only
|
| Homozygous prothrombin gene mutation
|
No
|
Postpartum only
|
| Other thrombophilia
|
No
|
None
|
| Antithrombin-III deficiency
|
No
|
None
|
Prophylaxis regimens
| Timing
|
Management
|
| Antepartum
|
Prophylactic or intermediate-dose LMWH
|
| Postpartum
|
Prophylactic or intermediate-dose LMWH, or warfarin (INR 2-3), for 6 weeks
|
