Thromboprophylaxis in pregnancy

From IDWiki

Indications for prophylaxis

Patient FHx of VTE? Prophylaxis
Prior VTE with provoked, transient risk factor None
Prior VTE either unprovoked or estrogen-related Antepartum and postpartum
Homozygous Factor V Leiden Yes Antepartum and postpartum
Homozygous prothrombin gene mutation Yes Antipartum and postpartum
Antithrombin-III deficiency Yes Antepartum and postpartum
Other thrombophilia Yes Postpartum only
Homozygous Factor V Leiden No Postpartum only
Homozygous prothrombin gene mutation No Postpartum only
Other thrombophilia No None
Antithrombin-III deficiency No None

Prophylaxis regimens

Timing Management
Antepartum Prophylactic or intermediate-dose LMWH
Postpartum Prophylactic or intermediate-dose LMWH, or warfarin (INR 2-3), for 6 weeks