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== Methicillin-resistant ''Staphylococcus aureus'' (MRSA) == ...infections like SSTI, or 15-20 if they have a significant MRSA infection (bacteremia, osteomyelitis, pneumonia)

**''mecA'' encodes PBP2a, conferring broad β-lactam resistance (MRSA) ===Bacteremia===

*Active against [[MRSA]], [[Staphylococcus epidermidis]], aerobic Gram-negative bacilli (similar t *Pneumonia and bacteremia: ceftaroline 600 mg IV q8h

* High dose for severe infections, including [[MRSA bacteremia]]: 8 to 10 mg/kg IV q24h

** Vancomycin is the preferred empiric choice for settings with high rates of MRSA; daptomycin if there are high rates of MIC >2 * If fungemia or bacteremia persists after removing the line beyond 72 hours, treat for 4 to 6 weeks

***Persistent bacteremia beyond 72 hours *MRSA: [[vancomycin]] 1g IV q12h for 2 weeks

...st medical history: include any relevant infections, as well, such as MSSA bacteremia or ESBL UTIs ...lonized, or have they been previously infected by, resistant bacteria like MRSA, VRE, ESBLs, ''Pseudomonas'', etc. Digging down into a patient's specific r

**'''Persistent''' infection (persistent bacteremia or fever for more than 5-7 days) following appropriate antimicrobials **'''Persistent bacteremia''' despite appropriate antibiotics for 5-7 days

**Recent dental work or surgical procedure associated with bacteremia ! colspan="5" |MRSA and other oxacillin-resistant ''[[Staphylococcus]]''

*Bacteremia without focus **MRSA: vanco, unless MIC ≥1, ± rifampin